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Protein

Glycerol kinase

Gene

glpK

Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

Enzyme regulationi

Inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol kinase (glpK)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei16SubstrateUniRule annotation1
Binding sitei20ATPUniRule annotation1
Binding sitei138SubstrateUniRule annotation1
Binding sitei269ATPUniRule annotation1
Binding sitei312ATP; via carbonyl oxygenUniRule annotation1
Binding sitei316ATP; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 18ATPUniRule annotation3
Nucleotide bindingi413 – 417ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycerol metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDARO159087:G1G4R-1984-MONOMER
UniPathwayiUPA00618; UER00672

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
Alternative name(s):
ATP:glycerol 3-phosphotransferaseUniRule annotation
GlycerokinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:glpKUniRule annotation
Ordered Locus Names:Daro_1922
OrganismiDechloromonas aromatica (strain RCB)
Taxonomic identifieri159087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesAzonexaceaeDechloromonas
Proteomesi
  • UP000000550 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000207251 – 502Glycerol kinaseAdd BLAST502

Proteomic databases

PRIDEiQ47ER3

Interactioni

Protein-protein interaction databases

STRINGi159087.Daro_1922

Structurei

3D structure databases

ProteinModelPortaliQ47ER3
SMRiQ47ER3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni86 – 87Substrate bindingUniRule annotation2
Regioni247 – 248Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QVN Bacteria
COG0554 LUCA
HOGENOMiHOG000222134
KOiK00864
OMAiWQDTRTQ
OrthoDBiPOG091H02FA

Family and domain databases

HAMAPiMF_00186 Glycerol_kin, 1 hit
InterProiView protein in InterPro
IPR000577 Carb_kinase_FGGY
IPR018485 Carb_kinase_FGGY_C
IPR018483 Carb_kinase_FGGY_CS
IPR018484 Carb_kinase_FGGY_N
IPR005999 Glycerol_kin
PfamiView protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit
PIRSFiPIRSF000538 GlpK, 1 hit
TIGRFAMsiTIGR01311 glycerol_kin, 1 hit
PROSITEiView protein in PROSITE
PS00933 FGGY_KINASES_1, 1 hit
PS00445 FGGY_KINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q47ER3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDRSDQFVL ALDQGTTSTR AILFGRKGDI HGVAQQEITQ HYPQPGWVEH
60 70 80 90 100
DAEEIWQAQL AVARAALRDN GILAKQIVAV GMTNQRETTV LWDRSSGEPL
110 120 130 140 150
HRAIVWQDRR TAGLCDELTT AGHAGLFRER TGLVLDAYFS GTKLKWLLDH
160 170 180 190 200
IPGARSRAER GELAFGTIDS WLTWKLSGGR AHVTDPSNAS RTLLFDIHRC
210 220 230 240 250
CWDEELLALL DIPMALLPRI VDSSGEIATI AAEWLGAEIP LSGIAGDQQA
260 270 280 290 300
ATFGQVCLQH GMAKNTYGTG CFLLMNTGQA PMASCHRLLT TIGWQRQGKT
310 320 330 340 350
TYLLEGSVFM GGATVQWLRD GLGLISSADQ IESLAASVAD NGGVYLVPAH
360 370 380 390 400
TGLGAPYWDP FARGALFGMT RGTTRAHIAR AALEAIAFQS ADVLQAMEKD
410 420 430 440 450
AGQSLSELRV DGGAARNDLL MQFQADLLGV PVVRPQVTET TALGAAYLAG
460 470 480 490 500
LAVGFWQDEA ELTALWRADR RFEPSMAEDR RSALFADWHR AVERSLHWAN

AT
Length:502
Mass (Da):54,712
Last modified:September 13, 2005 - v1
Checksum:iABA5AB0468B999F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000089 Genomic DNA Translation: AAZ46668.1
RefSeqiWP_011287670.1, NC_007298.1

Genome annotation databases

EnsemblBacteriaiAAZ46668; AAZ46668; Daro_1922
KEGGidar:Daro_1922

Similar proteinsi

Entry informationi

Entry nameiGLPK_DECAR
AccessioniPrimary (citable) accession number: Q47ER3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: February 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome