Reviewed, UniProtKB/Swiss-Prot Q47DI0 (KDSA_DECAR)

Names and origin

Protein names

Recommended name:
    2-dehydro-3-deoxyphosphooctonate aldolase
    EC=2.5.1.55
Alternative name(s):
    Phospho-2-dehydro-3-deoxyoctonate aldolase
    3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase
    KDO-8-phosphate synthetase
      Short name=KDO 8-P synthase
      Short name=KDOPS

Gene names

Name:	kdsA
Ordered Locus Names:	Daro_2365

Organism

Dechloromonas aromatica (strain RCB) [Complete proteome] [HAMAP]

Taxonomic identifier

159087 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Dechloromonas

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP MF_00056
Pathway	Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP MF_00056 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00056
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the kdsA family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-8-phosphooctulonate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	2-dehydro-3-deoxyphosphooctonate aldolase HAMAP MF_00056		PRO_0000304446

Sequences

	Sequence		Length	Mass (Da)
	Q47DI0-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 22B25636D0BFF904	FASTA	278	29,843
	10 20 30 40 50 60 MKLCGFEAGL DQPFFLIAGP CTAESEQLCL DVAGHMKEVC ARLGINYIFK ASYDKANRSS 70 80 90 100 110 120 GKSVRGLGLE EGLRIFSEVQ RQIGVPVLTD VHTIEDIPAV AAVVDVLQTP AFLCRQTDFI 130 140 150 160 170 180 HAVATCGKPV NIKKGQFLAP GDMKNVVDKA REVNNGADNI MVCERGASFG YNNLVSDMRS 190 200 210 220 230 240 LAIMRETGCP VVFDATHSVQ LPGGQGTTSG GQREFVPVLA RAAIAVGISG LFMETHPCPE 250 260 270 KAWSDGPNSW PLDRMESLLA TLVALDKAVK TAGFEELK

References

[1]

"Complete sequence of Dechloromonas aromatica RCB." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K., Schmutz J., Larimer F., Land M., Ivanova N., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000089 Genomic DNA. Translation: AAZ47101.1.
RefSeq	YP_285571.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q47DI0.
Genome annotation databases
GeneID	3566047.
GenomeReviews	Gene locus Daro_2365 in contig CP000089_GR.
KEGG	dar:Daro_2365.
NMPDR	fig|159087.4.peg.2341.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q47DI0.
OMA	VYKTSFD.
Enzyme and pathway databases
BioCyc	DARO159087:DARO_2365-MON.
Family and domain databases
HAMAP	MF_00056. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006269. KDO8P_synthase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR21057:SF2. KDO8P_synthase. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01362. KDO8P_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSA_DECAR

Accession

Primary (citable) accession number: Q47DI0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 13, 2005
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)