Reviewed, UniProtKB/Swiss-Prot Q47D83 (GCST_DECAR)

Names and origin

Protein names

Recommended name:
    Aminomethyltransferase
    EC=2.1.2.10
Alternative name(s):
    Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	Daro_2463

Organism

Dechloromonas aromatica (strain RCB) [Complete proteome] [HAMAP]

Taxonomic identifier

159087 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Dechloromonas

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity.
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the gcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: HAMAP transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	Aminomethyltransferase HAMAP MF_00259		PRO_1000047661

Sequences

	Sequence		Length	Mass (Da)
	Q47D83-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 84C543F352D04186	FASTA	363	39,136
	10 20 30 40 50 60 MLKKTVLNAA HRAMNARMVD FGGWDMPVNY GSQIEEHNAV RNNCGMFDVS HMCPVDVVGA 70 80 90 100 110 120 DCRTFLSRLV ANDVAKLKVS GKALYAAMLN EAGGVIDDLI IYFLTDTRFR IVVNAGTAEK 130 140 150 160 170 180 DLAWMQAKVA EWKLDVTITQ RRDGANNLGI IAVQGPNARA KVWEVLPQTK AATAGLKAFF 190 200 210 220 230 240 AAEVDQYFIA STGYTGEDGY EIMMPAGEAE ALWNKLNAAG VAPCGLGARD TLRLEAGMNL 250 260 270 280 290 300 YGQDMDETVS PLDAGLAWTV SLNTDRDFVG KAALVTNGQQ KQFLGLILLD KGVLRGHQKV 310 320 330 340 350 360 MTKQGDGEIT SGSFSPTLQQ SIALARLPLG VQIGDEVEVD IRGKALKAKV TKPVFARNGK AVI

References

[1]

"Complete sequence of Dechloromonas aromatica RCB." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K., Schmutz J., Larimer F., Land M., Ivanova N., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000089 Genomic DNA. Translation: AAZ47198.1.
RefSeq	YP_285668.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3568084.
GenomeReviews	Gene locus Daro_2463 in contig CP000089_GR.
KEGG	dar:Daro_2463.
NMPDR	fig|159087.4.peg.2829.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q47D83.
OMA	Q47D83. VEIRGKW.
Enzyme and pathway databases
BioCyc	DARO159087:DARO_2463-MON.
Family and domain databases
HAMAP	MF_00259. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. [Graphical view]
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. gcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_DECAR

Accession

Primary (citable) accession number: Q47D83

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)