Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q47D81

- GCSP_DECAR

UniProt

Q47D81 - GCSP_DECAR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciDARO159087:GI5B-2530-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Daro_2465
OrganismiDechloromonas aromatica (strain RCB)
Taxonomic identifieri159087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeDechloromonas
ProteomesiUP000000550: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 963963Glycine dehydrogenase (decarboxylating)PRO_0000227103Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei707 – 7071N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi159087.Daro_2465.

Structurei

3D structure databases

ProteinModelPortaliQ47D81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47D81-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLNLPLSAL EQHDEFIGRH IGPCSTEMAT MLTAIGADSL EQLIDQTVPA
60 70 80 90 100
AIRLPADLPL PAPRREHEAL ADLKAMASKN VVNKSCIGMG YYDTLTPKVI
110 120 130 140 150
LRNVMENPGW YTAYTPYQAE IAQGRLEALM NFQQMVIDLT GLEIANASLL
160 170 180 190 200
DEATAAAEAM TMARRVSKSK SNRFLVDANC FPQSIDVVKT RAAYFGFELV
210 220 230 240 250
IGNIDAHKDG DFFGALLQYP GDNGEVRDLT DVIAGLKAKG TTVAVASDLM
260 270 280 290 300
ALVLLKSPGA MGADIALGSS QRFGIPMGFG GPHAAFFATR EAFVRSMPGR
310 320 330 340 350
IIGISKDARG NTAYRMALQT REQHIRREKA NSNICTSQVL LANMAGMYVV
360 370 380 390 400
YHGAEGLRTI AGRIHRLTAI LAEGLKRASV NLLTKQFYDT VHFDLGARAE
410 420 430 440 450
SVYNDALAAG YNLRRVSAGV LGISFDETTT RDDVATLFKL IAQTTLDVAT
460 470 480 490 500
IDAQVAAADS ALPDSLIRSD AVLQHPVFNT HHTEHEMLRY LKSLQNKDLA
510 520 530 540 550
LDHSMISLGS CTMKLNATSE MIPVTWPEFG GIHPFAPRDQ AVGYLEMITS
560 570 580 590 600
LTEWLKTVTG FDAICMQPNS GAQGEYAGLV AIDRFHASRG EEHRNVCLIP
610 620 630 640 650
KSAHGTNPAT AQMANMKVVV VDCDENGNVD VADLKAKAEE HKDDLACLMI
660 670 680 690 700
TYPSTHGVFE EAIRDICAIV HANGGQVYMD GANLNAQVGL TSPGFIGADV
710 720 730 740 750
SHMNLHKTFA IPHGGGGPGM GPIGLKAHLA PFMADHVVQP TGDANRVNAG
760 770 780 790 800
QGAVSAAPFG SASILTISWM YLAMLGGAGV KKATQVAILN ANYVAKQLNA
810 820 830 840 850
HYPVLYVGKN GRVAHECILD IRPIKAATGI AEIDIAKRLM DYGFHAPTVS
860 870 880 890 900
FPVAGTIMVE PTESESKAEL DRFIGAMIAI REEIRQIENG VWTADNNPLK
910 920 930 940 950
NAPHSQADVM DAEWKHPYSR QQAVFPLPWV AANKFWPSVN RIDDVYGDRN
960
LNCACPPMEA YAD
Length:963
Mass (Da):104,019
Last modified:September 13, 2005 - v1
Checksum:iB6FAF847CADABB8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000089 Genomic DNA. Translation: AAZ47200.1.
RefSeqiYP_285670.1. NC_007298.1.

Genome annotation databases

EnsemblBacteriaiAAZ47200; AAZ47200; Daro_2465.
GeneIDi3568086.
KEGGidar:Daro_2465.
PATRICi21603612. VBIDecAro89105_2459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000089 Genomic DNA. Translation: AAZ47200.1 .
RefSeqi YP_285670.1. NC_007298.1.

3D structure databases

ProteinModelPortali Q47D81.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 159087.Daro_2465.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ47200 ; AAZ47200 ; Daro_2465 .
GeneIDi 3568086.
KEGGi dar:Daro_2465.
PATRICi 21603612. VBIDecAro89105_2459.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci DARO159087:GI5B-2530-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation."
    Salinero K.K., Keller K., Feil W.S., Feil H., Trong S., Di Bartolo G., Lapidus A.
    BMC Genomics 10:351-351(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RCB.

Entry informationi

Entry nameiGCSP_DECAR
AccessioniPrimary (citable) accession number: Q47D81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: November 26, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3