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Q47D81 (GCSP_DECAR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Daro_2465
OrganismDechloromonas aromatica (strain RCB) [Complete proteome] [HAMAP]
Taxonomic identifier159087 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeDechloromonas

Protein attributes

Sequence length963 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 963963Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000227103

Amino acid modifications

Modified residue7071N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q47D81 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: B6FAF847CADABB8A

FASTA963104,019
        10         20         30         40         50         60 
MPLNLPLSAL EQHDEFIGRH IGPCSTEMAT MLTAIGADSL EQLIDQTVPA AIRLPADLPL 

        70         80         90        100        110        120 
PAPRREHEAL ADLKAMASKN VVNKSCIGMG YYDTLTPKVI LRNVMENPGW YTAYTPYQAE 

       130        140        150        160        170        180 
IAQGRLEALM NFQQMVIDLT GLEIANASLL DEATAAAEAM TMARRVSKSK SNRFLVDANC 

       190        200        210        220        230        240 
FPQSIDVVKT RAAYFGFELV IGNIDAHKDG DFFGALLQYP GDNGEVRDLT DVIAGLKAKG 

       250        260        270        280        290        300 
TTVAVASDLM ALVLLKSPGA MGADIALGSS QRFGIPMGFG GPHAAFFATR EAFVRSMPGR 

       310        320        330        340        350        360 
IIGISKDARG NTAYRMALQT REQHIRREKA NSNICTSQVL LANMAGMYVV YHGAEGLRTI 

       370        380        390        400        410        420 
AGRIHRLTAI LAEGLKRASV NLLTKQFYDT VHFDLGARAE SVYNDALAAG YNLRRVSAGV 

       430        440        450        460        470        480 
LGISFDETTT RDDVATLFKL IAQTTLDVAT IDAQVAAADS ALPDSLIRSD AVLQHPVFNT 

       490        500        510        520        530        540 
HHTEHEMLRY LKSLQNKDLA LDHSMISLGS CTMKLNATSE MIPVTWPEFG GIHPFAPRDQ 

       550        560        570        580        590        600 
AVGYLEMITS LTEWLKTVTG FDAICMQPNS GAQGEYAGLV AIDRFHASRG EEHRNVCLIP 

       610        620        630        640        650        660 
KSAHGTNPAT AQMANMKVVV VDCDENGNVD VADLKAKAEE HKDDLACLMI TYPSTHGVFE 

       670        680        690        700        710        720 
EAIRDICAIV HANGGQVYMD GANLNAQVGL TSPGFIGADV SHMNLHKTFA IPHGGGGPGM 

       730        740        750        760        770        780 
GPIGLKAHLA PFMADHVVQP TGDANRVNAG QGAVSAAPFG SASILTISWM YLAMLGGAGV 

       790        800        810        820        830        840 
KKATQVAILN ANYVAKQLNA HYPVLYVGKN GRVAHECILD IRPIKAATGI AEIDIAKRLM 

       850        860        870        880        890        900 
DYGFHAPTVS FPVAGTIMVE PTESESKAEL DRFIGAMIAI REEIRQIENG VWTADNNPLK 

       910        920        930        940        950        960 
NAPHSQADVM DAEWKHPYSR QQAVFPLPWV AANKFWPSVN RIDDVYGDRN LNCACPPMEA 


YAD 

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References

[1]"Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation."
Salinero K.K., Keller K., Feil W.S., Feil H., Trong S., Di Bartolo G., Lapidus A.
BMC Genomics 10:351-351(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RCB.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000089 Genomic DNA. Translation: AAZ47200.1.
RefSeqYP_285670.1. NC_007298.1.

3D structure databases

ProteinModelPortalQ47D81.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING159087.Daro_2465.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ47200; AAZ47200; Daro_2465.
GeneID3568086.
KEGGdar:Daro_2465.
PATRIC21603612. VBIDecAro89105_2459.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycDARO159087:GI5B-2530-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_DECAR
AccessionPrimary (citable) accession number: Q47D81
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families