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Q47D81

- GCSP_DECAR

UniProt

Q47D81 - GCSP_DECAR

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciDARO159087:GI5B-2530-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Daro_2465
    OrganismiDechloromonas aromatica (strain RCB)
    Taxonomic identifieri159087 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeDechloromonas
    ProteomesiUP000000550: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 963963Glycine dehydrogenase (decarboxylating)PRO_0000227103Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei707 – 7071N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi159087.Daro_2465.

    Structurei

    3D structure databases

    ProteinModelPortaliQ47D81.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q47D81-1 [UniParc]FASTAAdd to Basket

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    MPLNLPLSAL EQHDEFIGRH IGPCSTEMAT MLTAIGADSL EQLIDQTVPA    50
    AIRLPADLPL PAPRREHEAL ADLKAMASKN VVNKSCIGMG YYDTLTPKVI 100
    LRNVMENPGW YTAYTPYQAE IAQGRLEALM NFQQMVIDLT GLEIANASLL 150
    DEATAAAEAM TMARRVSKSK SNRFLVDANC FPQSIDVVKT RAAYFGFELV 200
    IGNIDAHKDG DFFGALLQYP GDNGEVRDLT DVIAGLKAKG TTVAVASDLM 250
    ALVLLKSPGA MGADIALGSS QRFGIPMGFG GPHAAFFATR EAFVRSMPGR 300
    IIGISKDARG NTAYRMALQT REQHIRREKA NSNICTSQVL LANMAGMYVV 350
    YHGAEGLRTI AGRIHRLTAI LAEGLKRASV NLLTKQFYDT VHFDLGARAE 400
    SVYNDALAAG YNLRRVSAGV LGISFDETTT RDDVATLFKL IAQTTLDVAT 450
    IDAQVAAADS ALPDSLIRSD AVLQHPVFNT HHTEHEMLRY LKSLQNKDLA 500
    LDHSMISLGS CTMKLNATSE MIPVTWPEFG GIHPFAPRDQ AVGYLEMITS 550
    LTEWLKTVTG FDAICMQPNS GAQGEYAGLV AIDRFHASRG EEHRNVCLIP 600
    KSAHGTNPAT AQMANMKVVV VDCDENGNVD VADLKAKAEE HKDDLACLMI 650
    TYPSTHGVFE EAIRDICAIV HANGGQVYMD GANLNAQVGL TSPGFIGADV 700
    SHMNLHKTFA IPHGGGGPGM GPIGLKAHLA PFMADHVVQP TGDANRVNAG 750
    QGAVSAAPFG SASILTISWM YLAMLGGAGV KKATQVAILN ANYVAKQLNA 800
    HYPVLYVGKN GRVAHECILD IRPIKAATGI AEIDIAKRLM DYGFHAPTVS 850
    FPVAGTIMVE PTESESKAEL DRFIGAMIAI REEIRQIENG VWTADNNPLK 900
    NAPHSQADVM DAEWKHPYSR QQAVFPLPWV AANKFWPSVN RIDDVYGDRN 950
    LNCACPPMEA YAD 963
    Length:963
    Mass (Da):104,019
    Last modified:September 13, 2005 - v1
    Checksum:iB6FAF847CADABB8A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000089 Genomic DNA. Translation: AAZ47200.1.
    RefSeqiYP_285670.1. NC_007298.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ47200; AAZ47200; Daro_2465.
    GeneIDi3568086.
    KEGGidar:Daro_2465.
    PATRICi21603612. VBIDecAro89105_2459.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000089 Genomic DNA. Translation: AAZ47200.1 .
    RefSeqi YP_285670.1. NC_007298.1.

    3D structure databases

    ProteinModelPortali Q47D81.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 159087.Daro_2465.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ47200 ; AAZ47200 ; Daro_2465 .
    GeneIDi 3568086.
    KEGGi dar:Daro_2465.
    PATRICi 21603612. VBIDecAro89105_2459.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci DARO159087:GI5B-2530-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation."
      Salinero K.K., Keller K., Feil W.S., Feil H., Trong S., Di Bartolo G., Lapidus A.
      BMC Genomics 10:351-351(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RCB.

    Entry informationi

    Entry nameiGCSP_DECAR
    AccessioniPrimary (citable) accession number: Q47D81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3