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Q47D81

- GCSP_DECAR

UniProt

Q47D81 - GCSP_DECAR

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, Daro_2465
Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciDARO159087:GI5B-2530-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Daro_2465
OrganismiDechloromonas aromatica (strain RCB)
Taxonomic identifieri159087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeDechloromonas
ProteomesiUP000000550: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 963963Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000227103Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei707 – 7071N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi159087.Daro_2465.

Structurei

3D structure databases

ProteinModelPortaliQ47D81.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47D81-1 [UniParc]FASTAAdd to Basket

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MPLNLPLSAL EQHDEFIGRH IGPCSTEMAT MLTAIGADSL EQLIDQTVPA    50
AIRLPADLPL PAPRREHEAL ADLKAMASKN VVNKSCIGMG YYDTLTPKVI 100
LRNVMENPGW YTAYTPYQAE IAQGRLEALM NFQQMVIDLT GLEIANASLL 150
DEATAAAEAM TMARRVSKSK SNRFLVDANC FPQSIDVVKT RAAYFGFELV 200
IGNIDAHKDG DFFGALLQYP GDNGEVRDLT DVIAGLKAKG TTVAVASDLM 250
ALVLLKSPGA MGADIALGSS QRFGIPMGFG GPHAAFFATR EAFVRSMPGR 300
IIGISKDARG NTAYRMALQT REQHIRREKA NSNICTSQVL LANMAGMYVV 350
YHGAEGLRTI AGRIHRLTAI LAEGLKRASV NLLTKQFYDT VHFDLGARAE 400
SVYNDALAAG YNLRRVSAGV LGISFDETTT RDDVATLFKL IAQTTLDVAT 450
IDAQVAAADS ALPDSLIRSD AVLQHPVFNT HHTEHEMLRY LKSLQNKDLA 500
LDHSMISLGS CTMKLNATSE MIPVTWPEFG GIHPFAPRDQ AVGYLEMITS 550
LTEWLKTVTG FDAICMQPNS GAQGEYAGLV AIDRFHASRG EEHRNVCLIP 600
KSAHGTNPAT AQMANMKVVV VDCDENGNVD VADLKAKAEE HKDDLACLMI 650
TYPSTHGVFE EAIRDICAIV HANGGQVYMD GANLNAQVGL TSPGFIGADV 700
SHMNLHKTFA IPHGGGGPGM GPIGLKAHLA PFMADHVVQP TGDANRVNAG 750
QGAVSAAPFG SASILTISWM YLAMLGGAGV KKATQVAILN ANYVAKQLNA 800
HYPVLYVGKN GRVAHECILD IRPIKAATGI AEIDIAKRLM DYGFHAPTVS 850
FPVAGTIMVE PTESESKAEL DRFIGAMIAI REEIRQIENG VWTADNNPLK 900
NAPHSQADVM DAEWKHPYSR QQAVFPLPWV AANKFWPSVN RIDDVYGDRN 950
LNCACPPMEA YAD 963
Length:963
Mass (Da):104,019
Last modified:September 13, 2005 - v1
Checksum:iB6FAF847CADABB8A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000089 Genomic DNA. Translation: AAZ47200.1.
RefSeqiYP_285670.1. NC_007298.1.

Genome annotation databases

EnsemblBacteriaiAAZ47200; AAZ47200; Daro_2465.
GeneIDi3568086.
KEGGidar:Daro_2465.
PATRICi21603612. VBIDecAro89105_2459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000089 Genomic DNA. Translation: AAZ47200.1 .
RefSeqi YP_285670.1. NC_007298.1.

3D structure databases

ProteinModelPortali Q47D81.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 159087.Daro_2465.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ47200 ; AAZ47200 ; Daro_2465 .
GeneIDi 3568086.
KEGGi dar:Daro_2465.
PATRICi 21603612. VBIDecAro89105_2459.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci DARO159087:GI5B-2530-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation."
    Salinero K.K., Keller K., Feil W.S., Feil H., Trong S., Di Bartolo G., Lapidus A.
    BMC Genomics 10:351-351(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RCB.

Entry informationi

Entry nameiGCSP_DECAR
AccessioniPrimary (citable) accession number: Q47D81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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