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Protein

Malate dehydrogenase

Gene

mdh

Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93Substrate1
Binding sitei99Substrate1
Binding sitei106NAD1
Binding sitei113NAD1
Binding sitei132Substrate1
Binding sitei166Substrate1
Active sitei191Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 18NAD7
Nucleotide bindingi130 – 132NAD3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:Daro_2867
OrganismiDechloromonas aromatica (strain RCB)
Taxonomic identifieri159087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesAzonexaceaeDechloromonas
Proteomesi
  • UP000000550 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001133671 – 328Malate dehydrogenaseAdd BLAST328

Interactioni

Protein-protein interaction databases

STRINGi159087.Daro_2867.

Structurei

3D structure databases

ProteinModelPortaliQ47C34.
SMRiQ47C34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.

Phylogenomic databases

eggNOGiENOG4105D9Z. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000220953.
KOiK00024.
OMAiRPRTKGM.
OrthoDBiPOG091H03R4.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR036291. NAD(P)-bd_dom_sf.
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47C34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKAPMRVAI TGAAGQIGYS LLFRIASGEM LGKDQPVILQ LLDLPQAQQA
60 70 80 90 100
VKGVMMELED CAFPLLAGMV ATDDPNVAFK DADVCLLVGA RPRTKGMERA
110 120 130 140 150
DLLTANGAIF TVQGKAIAEN AKEDVKVLVV GNPCNTNAFI AAAAAKKVGR
160 170 180 190 200
TNPNNYHGML RLDHNRALSQ LAGKTGRAVS SLKKLVVWGN HSPTMYADYR
210 220 230 240 250
FCTSNGDSVK ALVNDHAWNN DVFLPTVGKR GAAIIEARGL SSAASAANAA
260 270 280 290 300
IDHVRDWVLG SDEWVTMGVP SDGSYGIPAG IVFGFPCECK GGKFSIIQGL
310 320
EIDEYSREKI NFTLKELTDE AEAVKDML
Length:328
Mass (Da):35,000
Last modified:September 13, 2005 - v1
Checksum:i8B631CE30E2D944A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000089 Genomic DNA. Translation: AAZ47597.1.
RefSeqiWP_011288595.1. NC_007298.1.

Genome annotation databases

EnsemblBacteriaiAAZ47597; AAZ47597; Daro_2867.
KEGGidar:Daro_2867.

Similar proteinsi

Entry informationi

Entry nameiMDH_DECAR
AccessioniPrimary (citable) accession number: Q47C34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: September 13, 2005
Last modified: October 25, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families