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Q47BI9 (GCH42_DECAR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2 2

EC=3.5.4.16
Gene names
Name:folE2-2
Ordered Locus Names:Daro_3062
OrganismDechloromonas aromatica (strain RCB) [Complete proteome] [HAMAP]
Taxonomic identifier159087 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeDechloromonas

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 270270GTP cyclohydrolase FolE2 2 HAMAP-Rule MF_01527
PRO_0000289487

Sites

Site1521May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q47BI9 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 9082AECA73AF9B78

FASTA27030,433
        10         20         30         40         50         60 
MSTPTSNIPD VQNSADTRHI AINKVGIKSI RHPIKVQDKS AGIQHTIAMF NMYVGLPHNF 

        70         80         90        100        110        120 
KGTHMSRFVE ILNSHEREIS VENFPTMLRD MVVKLEAETG HIEMNFPYFI NKTAPVSGVQ 

       130        140        150        160        170        180 
SLMDYDVTFI GDICHGEIAT SVKVVVPVTS LCPCSKKISE YGAHNQRSHV TVTAKTNDFM 

       190        200        210        220        230        240 
WIEEIVQLVE QEASCELFGL LKRPDEKYVT ERAYDNPKFV EDMVRDVAAR LNAEARVDAY 

       250        260        270 
VVESENFESI HNHSAYALIE NDKKNPLAHA 

« Hide

References

[1]"Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation."
Salinero K.K., Keller K., Feil W.S., Feil H., Trong S., Di Bartolo G., Lapidus A.
BMC Genomics 10:351-351(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RCB.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000089 Genomic DNA. Translation: AAZ47792.1.
RefSeqYP_286262.1. NC_007298.1.

3D structure databases

ProteinModelPortalQ47BI9.
SMRQ47BI9. Positions 19-263.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING159087.Daro_3062.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ47792; AAZ47792; Daro_3062.
GeneID3566237.
KEGGdar:Daro_3062.
PATRIC21604792. VBIDecAro89105_3041.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMAINMYVDL.
OrthoDBEOG6X6RBH.
ProtClustDBCLSK2525992.

Enzyme and pathway databases

BioCycDARO159087:GI5B-3135-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH42_DECAR
AccessionPrimary (citable) accession number: Q47BI9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2005
Last modified: February 19, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways