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Q47BI9

- GCH42_DECAR

UniProt

Q47BI9 - GCH42_DECAR

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Protein

GTP cyclohydrolase FolE2 2

Gene

folE2-2

Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei152 – 1521May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciDARO159087:GI5B-3135-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2-2UniRule annotation
Ordered Locus Names:Daro_3062
OrganismiDechloromonas aromatica (strain RCB)
Taxonomic identifieri159087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeDechloromonas
ProteomesiUP000000550: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270GTP cyclohydrolase FolE2 2PRO_0000289487Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi159087.Daro_3062.

Structurei

3D structure databases

ProteinModelPortaliQ47BI9.
SMRiQ47BI9. Positions 19-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47BI9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTPTSNIPD VQNSADTRHI AINKVGIKSI RHPIKVQDKS AGIQHTIAMF
60 70 80 90 100
NMYVGLPHNF KGTHMSRFVE ILNSHEREIS VENFPTMLRD MVVKLEAETG
110 120 130 140 150
HIEMNFPYFI NKTAPVSGVQ SLMDYDVTFI GDICHGEIAT SVKVVVPVTS
160 170 180 190 200
LCPCSKKISE YGAHNQRSHV TVTAKTNDFM WIEEIVQLVE QEASCELFGL
210 220 230 240 250
LKRPDEKYVT ERAYDNPKFV EDMVRDVAAR LNAEARVDAY VVESENFESI
260 270
HNHSAYALIE NDKKNPLAHA
Length:270
Mass (Da):30,433
Last modified:September 13, 2005 - v1
Checksum:i9082AECA73AF9B78
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000089 Genomic DNA. Translation: AAZ47792.1.
RefSeqiYP_286262.1. NC_007298.1.

Genome annotation databases

EnsemblBacteriaiAAZ47792; AAZ47792; Daro_3062.
GeneIDi3566237.
KEGGidar:Daro_3062.
PATRICi21604792. VBIDecAro89105_3041.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000089 Genomic DNA. Translation: AAZ47792.1 .
RefSeqi YP_286262.1. NC_007298.1.

3D structure databases

ProteinModelPortali Q47BI9.
SMRi Q47BI9. Positions 19-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 159087.Daro_3062.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ47792 ; AAZ47792 ; Daro_3062 .
GeneIDi 3566237.
KEGGi dar:Daro_3062.
PATRICi 21604792. VBIDecAro89105_3041.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci DARO159087:GI5B-3135-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation."
    Salinero K.K., Keller K., Feil W.S., Feil H., Trong S., Di Bartolo G., Lapidus A.
    BMC Genomics 10:351-351(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RCB.

Entry informationi

Entry nameiGCH42_DECAR
AccessioniPrimary (citable) accession number: Q47BI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2005
Last modified: October 1, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3