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Q47BI9

- GCH42_DECAR

UniProt

Q47BI9 - GCH42_DECAR

Protein

GTP cyclohydrolase FolE2 2

Gene

folE2-2

Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei152 – 1521May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciDARO159087:GI5B-3135-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2 2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2-2UniRule annotation
    Ordered Locus Names:Daro_3062
    OrganismiDechloromonas aromatica (strain RCB)
    Taxonomic identifieri159087 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeDechloromonas
    ProteomesiUP000000550: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270GTP cyclohydrolase FolE2 2PRO_0000289487Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi159087.Daro_3062.

    Structurei

    3D structure databases

    ProteinModelPortaliQ47BI9.
    SMRiQ47BI9. Positions 19-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q47BI9-1 [UniParc]FASTAAdd to Basket

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    MSTPTSNIPD VQNSADTRHI AINKVGIKSI RHPIKVQDKS AGIQHTIAMF    50
    NMYVGLPHNF KGTHMSRFVE ILNSHEREIS VENFPTMLRD MVVKLEAETG 100
    HIEMNFPYFI NKTAPVSGVQ SLMDYDVTFI GDICHGEIAT SVKVVVPVTS 150
    LCPCSKKISE YGAHNQRSHV TVTAKTNDFM WIEEIVQLVE QEASCELFGL 200
    LKRPDEKYVT ERAYDNPKFV EDMVRDVAAR LNAEARVDAY VVESENFESI 250
    HNHSAYALIE NDKKNPLAHA 270
    Length:270
    Mass (Da):30,433
    Last modified:September 13, 2005 - v1
    Checksum:i9082AECA73AF9B78
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000089 Genomic DNA. Translation: AAZ47792.1.
    RefSeqiYP_286262.1. NC_007298.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ47792; AAZ47792; Daro_3062.
    GeneIDi3566237.
    KEGGidar:Daro_3062.
    PATRICi21604792. VBIDecAro89105_3041.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000089 Genomic DNA. Translation: AAZ47792.1 .
    RefSeqi YP_286262.1. NC_007298.1.

    3D structure databases

    ProteinModelPortali Q47BI9.
    SMRi Q47BI9. Positions 19-263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 159087.Daro_3062.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ47792 ; AAZ47792 ; Daro_3062 .
    GeneIDi 3566237.
    KEGGi dar:Daro_3062.
    PATRICi 21604792. VBIDecAro89105_3041.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci DARO159087:GI5B-3135-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation."
      Salinero K.K., Keller K., Feil W.S., Feil H., Trong S., Di Bartolo G., Lapidus A.
      BMC Genomics 10:351-351(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RCB.

    Entry informationi

    Entry nameiGCH42_DECAR
    AccessioniPrimary (citable) accession number: Q47BI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3