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Protein

Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase

Gene

Daro_3096

Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).By similarity

Catalytic activityi

4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate.
Oxaloacetate = pyruvate + CO2.

Cofactori

a divalent metal cationBy similarityNote: Divalent metal cation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei101SubstrateBy similarity1
Metal bindingi102Divalent metal cationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandMetal-binding

Enzyme and pathway databases

BioCyciDARO159087:G1G4R-3195-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase (EC:4.1.3.17)
Short name:
HMG aldolase
Alternative name(s):
Oxaloacetate decarboxylase (EC:4.1.1.3)
Short name:
OAA decarboxylase
Regulator of ribonuclease activity homolog
RraA-like protein
Gene namesi
Ordered Locus Names:Daro_3096
OrganismiDechloromonas aromatica (strain RCB)
Taxonomic identifieri159087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesAzonexaceaeDechloromonas
Proteomesi
  • UP000000550 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000138361 – 163Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolaseAdd BLAST163

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi159087.Daro_3096

Structurei

3D structure databases

ProteinModelPortaliQ47BF5
SMRiQ47BF5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni79 – 82Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the class II aldolase/RraA-like family.Curated

Phylogenomic databases

eggNOGiENOG4108YYX Bacteria
COG0684 LUCA
HOGENOMiHOG000252803
KOiK02553
OMAiRSCDTQF
OrthoDBiPOG091H03SM

Family and domain databases

CDDicd16841 RraA_family, 1 hit
InterProiView protein in InterPro
IPR010203 RraA
IPR005493 RraA/RraA-like
IPR036704 RraA/RraA-like_sf
PfamiView protein in Pfam
PF03737 RraA-like, 1 hit
SUPFAMiSSF89562 SSF89562, 1 hit
TIGRFAMsiTIGR01935 NOT-MenG, 1 hit

Sequencei

Sequence statusi: Complete.

Q47BF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFKTPDLCD EFESELGKTV RVVTPMFQRY GGRTSFSGQI VTLKIFEDNS
60 70 80 90 100
LVREVFGEDG KGKVLVIDGG GSLRCALVGD QLAILANKNG WEGVVVYGCI
110 120 130 140 150
RDSGDINGID IGVRALNTHP QKTLKKGVGD KNVAVTFGGV TFNPGEYLYA
160
DEDGVLVSGK ALT
Length:163
Mass (Da):17,451
Last modified:September 13, 2005 - v1
Checksum:i68F51B34D2E5F261
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000089 Genomic DNA Translation: AAZ47826.1
RefSeqiWP_011288824.1, NC_007298.1

Genome annotation databases

EnsemblBacteriaiAAZ47826; AAZ47826; Daro_3096
KEGGidar:Daro_3096

Similar proteinsi

Entry informationi

Entry nameiRRAAH_DECAR
AccessioniPrimary (citable) accession number: Q47BF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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