ID   PUR5_DECAR              Reviewed;         347 AA.
AC   Q47B77;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase;
DE            EC=6.3.3.1;
DE   AltName: Full=AIRS;
DE   AltName: Full=Phosphoribosyl-aminoimidazole synthetase;
DE   AltName: Full=AIR synthase;
GN   Name=purM; OrderedLocusNames=Daro_3174;
OS   Dechloromonas aromatica (strain RCB).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales;
OC   Rhodocyclaceae; Dechloromonas.
OX   NCBI_TaxID=159087;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K.,
RA   Schmutz J., Larimer F., Land M., Ivanova N., Richardson P.;
RT   "Complete sequence of Dechloromonas aromatica RCB.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + 2-(formamido)-N(1)-(5-phospho-D-
CC       ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-
CC       ribosyl)imidazole.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-
CC       formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/5.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the AIR synthase family.
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DR   EMBL; CP000089; AAZ47904.1; -; Genomic_DNA.
DR   RefSeq; YP_286374.1; -.
DR   GeneID; 3567174; -.
DR   GenomeReviews; CP000089_GR; Daro_3174.
DR   KEGG; dar:Daro_3174; -.
DR   NMPDR; fig|159087.4.peg.3469; -.
DR   HOGENOM; Q47B77; -.
DR   OMA; Q47B77; CGKLDPE.
DR   BioCyc; DARO159087:DARO_3174-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004641; F:phosphoribosylformylglycinamidine cyclo-lig...; IEA:HAMAP.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00741; -; 1.
DR   InterPro; IPR000728; AIR_synth.
DR   InterPro; IPR010918; AIR_synth_C.
DR   InterPro; IPR004733; PurM_cligase.
DR   Pfam; PF00586; AIRS; 1.
DR   Pfam; PF02769; AIRS_C; 1.
DR   TIGRFAMs; TIGR00878; purM; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding;
KW   Purine biosynthesis.
FT   CHAIN         1    347       Phosphoribosylformylglycinamidine cyclo-
FT                                ligase.
FT                                /FTId=PRO_0000258349.
SQ   SEQUENCE   347 AA;  36611 MW;  33DC0FAAD30878E0 CRC64;
     MTQNTSLSYR DAGVDIDAGD ALVERIKPLA KKTLREGVLG GIGGFGALFE VPKRYKEPVL
     VSGTDGVGTK LRLAFDLNRH DTVGQDLVAM SVNDILVLGA ESLFFLDYFA CGKLDVDTAA
     AVVGGIAKGC ELAGCALIGG ETAEMPGMYP AGEYDLAGFA VGVVEKSKAI DGKASITPGD
     VVLGLASSGA HSNGYSLVRK IIERSKPDMN AKFDGERTLA DVVMAPTRIY VKQVLATMQK
     VTIKGMAHIT GGGLLENVPR VLPENTVAEL EKAAWPRPKL FDWMQAEGNV AENEMHRVFN
     CGIGLVIVVA AADADAAMAE LKAQGEAVYR IGKIRARSGD EAQTLVV
//