Reviewed, UniProtKB/Swiss-Prot Q47B77 (PUR5_DECAR)

Names and origin

Protein names

Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligase
    EC=6.3.3.1
Alternative name(s):
    AIRS
    Phosphoribosyl-aminoimidazole synthetase
    AIR synthase

Gene names

Name:	purM
Ordered Locus Names:	Daro_3174

Organism

Dechloromonas aromatica (strain RCB) [Complete proteome] [HAMAP]

Taxonomic identifier

159087 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Dechloromonas

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/5. HAMAP MF_00741
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741		PRO_0000258349

Sequences

	Sequence		Length	Mass (Da)
	Q47B77-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 33DC0FAAD30878E0	FASTA	347	36,611
	10 20 30 40 50 60 MTQNTSLSYR DAGVDIDAGD ALVERIKPLA KKTLREGVLG GIGGFGALFE VPKRYKEPVL 70 80 90 100 110 120 VSGTDGVGTK LRLAFDLNRH DTVGQDLVAM SVNDILVLGA ESLFFLDYFA CGKLDVDTAA 130 140 150 160 170 180 AVVGGIAKGC ELAGCALIGG ETAEMPGMYP AGEYDLAGFA VGVVEKSKAI DGKASITPGD 190 200 210 220 230 240 VVLGLASSGA HSNGYSLVRK IIERSKPDMN AKFDGERTLA DVVMAPTRIY VKQVLATMQK 250 260 270 280 290 300 VTIKGMAHIT GGGLLENVPR VLPENTVAEL EKAAWPRPKL FDWMQAEGNV AENEMHRVFN 310 320 330 340 CGIGLVIVVA AADADAAMAE LKAQGEAVYR IGKIRARSGD EAQTLVV

References

[1]

"Complete sequence of Dechloromonas aromatica RCB." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K., Schmutz J., Larimer F., Land M., Ivanova N., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000089 Genomic DNA. Translation: AAZ47904.1.
RefSeq	YP_286374.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3567174.
GenomeReviews	Gene locus Daro_3174 in contig CP000089_GR.
KEGG	dar:Daro_3174.
NMPDR	fig|159087.4.peg.3469.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q47B77.
OMA	Q47B77. CGKLDPE.
Enzyme and pathway databases
BioCyc	DARO159087:DARO_3174-MON.
Family and domain databases
HAMAP	MF_00741. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_DECAR

Accession

Primary (citable) accession number: Q47B77

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)