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Protein

Pantothenate synthetase

Gene

panC

Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei33Proton donorUniRule annotation1
Binding sitei57Beta-alanineUniRule annotation1
Binding sitei57PantoateUniRule annotation1
Binding sitei149PantoateUniRule annotation1
Binding sitei172ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 33ATPUniRule annotation8
Nucleotide bindingi143 – 146ATPUniRule annotation4
Nucleotide bindingi180 – 183ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPantothenate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:Daro_3186
OrganismiDechloromonas aromatica (strain RCB)
Taxonomic identifieri159087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesAzonexaceaeDechloromonas
Proteomesi
  • UP000000550 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003054341 – 274Pantothenate synthetaseAdd BLAST274

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi159087.Daro_3186.

Structurei

3D structure databases

ProteinModelPortaliQ47B65.
SMRiQ47B65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R03. Bacteria.
COG0414. LUCA.
HOGENOMiHOG000175516.
KOiK01918.
OMAiLFNMVQP.
OrthoDBiPOG091H00FM.

Family and domain databases

CDDicd00560. PanC. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC. 1 hit.
InterProiView protein in InterPro
IPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
PANTHERiPTHR21299:SF4. PTHR21299:SF4. 1 hit.
PfamiView protein in Pfam
PF02569. Pantoate_ligase. 1 hit.
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47B65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIHSSIADL RSALKNRGRV VFVPTMGNLH AGHISLMTQA RAHGDTVVAS
60 70 80 90 100
IFVNRLQFGP NEDFDKYPRT FQADCDKLAA AGVDVLFAPT EADLYPEPQE
110 120 130 140 150
YTVEPPAIQN ILDGEFRPGH FRGVATVVLK LFNCVQPQAA MFGKKDYQQL
160 170 180 190 200
MVIRNMTRQL ALPIDIIGGE TVRAEDGLAL SSRNGYLSAA ERTEAPRLYR
210 220 230 240 250
LLNEIRAAIR AGETDTVKLE NEAIAALTAA GWKNDYVAVR QQSDLSMPKG
260 270
VNAPLVALAA SRLGSTRLID NIEI
Length:274
Mass (Da):30,016
Last modified:September 13, 2005 - v1
Checksum:iD70413102772C61F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000089 Genomic DNA. Translation: AAZ47916.1.
RefSeqiWP_011288912.1. NC_007298.1.

Genome annotation databases

EnsemblBacteriaiAAZ47916; AAZ47916; Daro_3186.
KEGGidar:Daro_3186.

Similar proteinsi

Entry informationi

Entry nameiPANC_DECAR
AccessioniPrimary (citable) accession number: Q47B65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 13, 2005
Last modified: August 30, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families