Reviewed, UniProtKB/Swiss-Prot Q47B12 (MHPF_DECAR)

Names and origin

Protein names

Recommended name:
    Acetaldehyde dehydrogenase
    EC=1.2.1.10
Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating]

Gene names

Name:	mhpF
Ordered Locus Names:	Daro_3239

Organism

Dechloromonas aromatica (strain RCB) [Complete proteome] [HAMAP]

Taxonomic identifier

159087 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Dechloromonas

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the terminal reaction in meta-cleavage pathways, that is, the transformation of acetaldehyde into acetyl coenzyme A By similarity.
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657
Pathway	Aromatic compound metabolism; 3-phenylpropionic acid degradation. HAMAP MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family. MhpF subfamily.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	amino acid metabolic process Inferred from electronic annotation. Source: InterPro aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Acetaldehyde dehydrogenase HAMAP MF_01657		PRO_0000337978

Sequences

	Sequence		Length	Mass (Da)
	Q47B12-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: BA1845382DFE9832	FASTA	314	33,113
	10 20 30 40 50 60 MNKKLKVAII GPGNIGTDLM IKIMRHGEHL EMGAMVGIDP QSDGLARAQR MGVATTHEGV 70 80 90 100 110 120 EGLTRLPVFA DIDIVFDATS AGAHVRNDAF LRSLKPNIRM VDLTPAAIGP YCIPVVNGAA 130 140 150 160 170 180 HDEALNVNMV TCGGQATIPM VAAVSRVAKV HYGEIIASIS SKSAGPGTRA NIDEFTETTS 190 200 210 220 230 240 KAIEAVGGAA KGKAIIILNP AEPPLIMRDT VYCLSELVDE DEIAASVAQM AADVQKYVPG 250 260 270 280 290 300 YRLKQKVQFD IIPASRPINI PGVGQRMSGL KTSVFLEVEG AAHYLPAYAG NLDIMTSAAK 310 TTAERMAARI LSAA

References

[1]

"Complete sequence of Dechloromonas aromatica RCB." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K., Schmutz J., Larimer F., Land M., Ivanova N., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000089 Genomic DNA. Translation: AAZ47969.1.
RefSeq	YP_286439.1.
3D structure databases
SMR	Q47B12. Positions 1-313.
ModBase	Search...
Genome annotation databases
GeneID	3566585.
GenomeReviews	Gene locus Daro_3239 in contig CP000089_GR.
KEGG	dar:Daro_3239.
NMPDR	fig|159087.4.peg.3778.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q47B12.
OMA	Q47B12. KEIDIVF.
Enzyme and pathway databases
BioCyc	DARO159087:DARO_3239-MON.
Family and domain databases
HAMAP	MF_01657. [Tree]
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
PANTHER	PTHR21123. Acetylald_dh. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
TIGRFAMs	TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MHPF_DECAR

Accession

Primary (citable) accession number: Q47B12

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)