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Protein

Acetaldehyde dehydrogenase 3

Gene

Daro_3239

Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei132Acyl-thioester intermediateUniRule annotation1
Binding sitei291NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi163 – 171NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Enzyme and pathway databases

BioCyciDARO159087:GI5B-3284-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 3UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 3UniRule annotation
Gene namesi
Ordered Locus Names:Daro_3239
OrganismiDechloromonas aromatica (strain RCB)
Taxonomic identifieri159087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesAzonexaceaeDechloromonas
Proteomesi
  • UP000000550 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003379781 – 314Acetaldehyde dehydrogenase 3Add BLAST314

Interactioni

Protein-protein interaction databases

STRINGi159087.Daro_3239.

Structurei

3D structure databases

ProteinModelPortaliQ47B12.
SMRiQ47B12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV. Bacteria.
COG4569. LUCA.
HOGENOMiHOG000052149.
KOiK04073.
OMAiVRYMVGV.
OrthoDBiPOG091H09NP.

Family and domain databases

HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiView protein in InterPro
IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR036291. NAD(P)-bd_dom_sf.
IPR000534. Semialdehyde_DH_NAD-bd.
PfamiView protein in Pfam
PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiView protein in SMART
SM00859. Semialdhyde_dh. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47B12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKLKVAII GPGNIGTDLM IKIMRHGEHL EMGAMVGIDP QSDGLARAQR
60 70 80 90 100
MGVATTHEGV EGLTRLPVFA DIDIVFDATS AGAHVRNDAF LRSLKPNIRM
110 120 130 140 150
VDLTPAAIGP YCIPVVNGAA HDEALNVNMV TCGGQATIPM VAAVSRVAKV
160 170 180 190 200
HYGEIIASIS SKSAGPGTRA NIDEFTETTS KAIEAVGGAA KGKAIIILNP
210 220 230 240 250
AEPPLIMRDT VYCLSELVDE DEIAASVAQM AADVQKYVPG YRLKQKVQFD
260 270 280 290 300
IIPASRPINI PGVGQRMSGL KTSVFLEVEG AAHYLPAYAG NLDIMTSAAK
310
TTAERMAARI LSAA
Length:314
Mass (Da):33,113
Last modified:September 13, 2005 - v1
Checksum:iBA1845382DFE9832
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000089 Genomic DNA. Translation: AAZ47969.1.
RefSeqiWP_011288965.1. NC_007298.1.

Genome annotation databases

EnsemblBacteriaiAAZ47969; AAZ47969; Daro_3239.
KEGGidar:Daro_3239.

Similar proteinsi

Entry informationi

Entry nameiACDH3_DECAR
AccessioniPrimary (citable) accession number: Q47B12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: September 13, 2005
Last modified: October 25, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families