Q47B12 (ACDH3_DECAR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase 3
EC=1.2.1.10

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 3

Gene names

Ordered Locus Names:

Daro_3239

Organism

Dechloromonas aromatica (strain RCB) [Complete proteome] [HAMAP]

Taxonomic identifier

159087 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Dechloromonas

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Acetaldehyde dehydrogenase 3 HAMAP MF_01657		PRO_0000337978
Regions
	Nucleotide binding	163 – 171	9	NAD By similarity
Sites
	Binding site	291	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q47B12 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: BA1845382DFE9832	FASTA	314	33,113
	10 20 30 40 50 60 MNKKLKVAII GPGNIGTDLM IKIMRHGEHL EMGAMVGIDP QSDGLARAQR MGVATTHEGV 70 80 90 100 110 120 EGLTRLPVFA DIDIVFDATS AGAHVRNDAF LRSLKPNIRM VDLTPAAIGP YCIPVVNGAA 130 140 150 160 170 180 HDEALNVNMV TCGGQATIPM VAAVSRVAKV HYGEIIASIS SKSAGPGTRA NIDEFTETTS 190 200 210 220 230 240 KAIEAVGGAA KGKAIIILNP AEPPLIMRDT VYCLSELVDE DEIAASVAQM AADVQKYVPG 250 260 270 280 290 300 YRLKQKVQFD IIPASRPINI PGVGQRMSGL KTSVFLEVEG AAHYLPAYAG NLDIMTSAAK 310 TTAERMAARI LSAA

References

[1]

"Complete sequence of Dechloromonas aromatica RCB." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K., Schmutz J., Larimer F., Land M., Ivanova N., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RCB.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000089 Genomic DNA. Translation: AAZ47969.1.
RefSeq	YP_286439.1. NC_007298.1.
3D structure databases
ProteinModelPortal	Q47B12.
SMR	Q47B12. Positions 1-313.
ModBase	Search...
Protein-protein interaction databases
STRING	Q47B12.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3566585.
GenomeReviews	Gene locus Daro_3239 in contig CP000089_GR.
KEGG	dar:Daro_3239.
NMPDR	fig|159087.4.peg.3778.
PATRIC	21605152. VBIDecAro89105_3221.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4569.
HOGENOM	HBG300125.
OMA	ASRPINI.
ProtClustDB	PRK08300.
Enzyme and pathway databases
BioCyc	DARO159087:DARO_3239-MONOMER.
Family and domain databases
HAMAP	MF_01657. Ac_ald_DH_ac. [Tree]
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K04073.
PANTHER	PTHR21123. Acetylald_dh. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. Ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH3_DECAR

Accession

Primary (citable) accession number: Q47B12

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program