Reviewed, UniProtKB/Swiss-Prot Q47AL9 (HIS82_DECAR)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 2
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 2

Gene names

Name:	hisC2
Ordered Locus Names:	Daro_3383

Organism

Dechloromonas aromatica (strain RCB) [Complete proteome] [HAMAP]

Taxonomic identifier

159087 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Dechloromonas

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Histidinol-phosphate aminotransferase 2 HAMAP MF_01023		PRO_0000153353
Amino acid modifications
	Modified residue	214	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q47AL9-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: B54E4A301D925E92	FASTA	356	39,296
	10 20 30 40 50 60 MSRFWSQVVR DLTPYVPGEQ PKIANLIKLN TNENPFPPSP RVVAAIQAEL GDDAARLRLY 70 80 90 100 110 120 PDPNADLLKA AVARRHTVSA QQVFVGNGSD EVLAHIFMAL LKHDQPIIFP DITYSFYPVY 130 140 150 160 170 180 CGLYGVEYQT LPLADDFSIN PADYCDRPNG GIIFPNPNAP TGRLLPLDAI EQMLKANPDS 190 200 210 220 230 240 VVVVDEAYVD FGGETAISLV DRYDNLLVVH TLSKSRSLAG MRVGFAVGHA ALIEALERVK 250 260 270 280 290 300 NSFNSYPLDR LAIVAAVAAM EDEAYFAQCC HAVMATRNTL TAELTELGFE VLPSTANFIF 310 320 330 340 350 TRHPQRDAAE LAKALRERNI IVRHFKLPRI DQFLRITVGT DGECKALTDA LRQITG

References

[1]

"Complete sequence of Dechloromonas aromatica RCB." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K., Schmutz J., Larimer F., Land M., Ivanova N., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000089 Genomic DNA. Translation: AAZ48112.1.
RefSeq	YP_286582.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3567113.
GenomeReviews	Gene locus Daro_3383 in contig CP000089_GR.
KEGG	dar:Daro_3383.
NMPDR	fig|159087.4.peg.3631.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q47AL9.
OMA	Q47AL9. AAYEDDA.
Enzyme and pathway databases
BioCyc	DARO159087:DARO_3383-MON.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR004839. Aminotrans_I/II. IPR001917. Aminotrans_II_pyridoxalP_BS. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS82_DECAR

Accession

Primary (citable) accession number: Q47AL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)