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Protein

Ribulose bisphosphate carboxylase

Gene

cbbM

Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In contrast to form I RuBisCO, the form II RuBisCO are composed solely of large subunits.

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.

Cofactori

Mg2+Note: Binds 1 Mg2+ ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei111Substrate; in homodimeric partner1
Active sitei166Proton acceptor1
Binding sitei168Substrate1
Metal bindingi191Magnesium; via carbamate group1
Metal bindingi193Magnesium1
Metal bindingi194Magnesium1
Active sitei287Proton acceptor1
Binding sitei288Substrate1
Binding sitei321Substrate1
Sitei329Transition state stabilizer1
Binding sitei368Substrate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase, Monooxygenase, Oxidoreductase
Biological processCalvin cycle, Carbon dioxide fixation
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylase (EC:4.1.1.39)
Short name:
RuBisCO
Gene namesi
Name:cbbM
Ordered Locus Names:Daro_3637
OrganismiDechloromonas aromatica (strain RCB)
Taxonomic identifieri159087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesAzonexaceaeDechloromonas
Proteomesi
  • UP000000550 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002514061 – 459Ribulose bisphosphate carboxylaseAdd BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei191N6-carboxylysine1

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi159087.Daro_3637.

Structurei

3D structure databases

ProteinModelPortaliQ479W5.
SMRiQ479W5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type II subfamily.

Phylogenomic databases

eggNOGiENOG4105DT1. Bacteria.
COG1850. LUCA.
HOGENOMiHOG000230831.
KOiK01601.
OMAiTARRQYP.
OrthoDBiPOG091H14UZ.

Family and domain databases

CDDicd08211. RuBisCO_large_II. 1 hit.
Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01339. RuBisCO_L_type2. 1 hit.
InterProiView protein in InterPro
IPR020878. RuBisCo_large_chain_AS.
IPR000685. RuBisCO_lsu_C.
IPR036376. RuBisCO_lsu_C_sf.
IPR017443. RuBisCO_lsu_fd_N.
IPR036422. RuBisCO_lsu_N_sf.
IPR020871. RuBisCO_lsuII.
PfamiView protein in Pfam
PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEiView protein in PROSITE
PS00157. RUBISCO_LARGE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q479W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQSNRYADL SLTEAELIAG GQHILCAYKM KPKAGHRYLE AAAHFAAESS
60 70 80 90 100
TGTNVEVCTT DEFTKGVDAL VYHIDEASED MRIAYPLDLF DRNMTDGRMM
110 120 130 140 150
MASFLTLTIG NNQGMGDIEH AKMVDFYVPR RGIELFDGPS KDISDLWRML
160 170 180 190 200
GRPVKDGGYI AGTIIKPKLG LRPEPFARAA YEFWLGGDFI KNDEPQGNQV
210 220 230 240 250
FAPLKKVIPL VYDSMKRAMD ETGEAKLFSM NITADDHFEM CARADFALEA
260 270 280 290 300
FGPDADKLAF LVDGYVGGPG MITTARRQYP NQYLHYHRAG HGAVTSPSSK
310 320 330 340 350
RGYTAYVLAK MSRLQGASGI HVGTMGYGKM EGDKDDRACA YIIERDSYTG
360 370 380 390 400
PVYHQEWYGM KPTTPIISGG MNALRLPGFF ENLGHGNVIN TAGGGAYGHI
410 420 430 440 450
DSPAAGARSL RQAYDCWKAG ADPVEWARDH YEFARAFESF PQDADQLYPG

WRHKLRPAA
Length:459
Mass (Da):50,788
Last modified:September 13, 2005 - v1
Checksum:i813D3C3753EE1C0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000089 Genomic DNA. Translation: AAZ48366.1.
RefSeqiWP_011289362.1. NC_007298.1.

Genome annotation databases

EnsemblBacteriaiAAZ48366; AAZ48366; Daro_3637.
KEGGidar:Daro_3637.

Similar proteinsi

Entry informationi

Entry nameiRBL2_DECAR
AccessioniPrimary (citable) accession number: Q479W5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: September 13, 2005
Last modified: October 25, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families