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Q479E6

- ACDH5_DECAR

UniProt

Q479E6 - ACDH5_DECAR

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Protein
Acetaldehyde dehydrogenase 5
Gene
Daro_3807
Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei130 – 1301Acyl-thioester intermediate By similarity
Binding sitei272 – 2721NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 144NAD By similarity
Nucleotide bindingi161 – 1699NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciDARO159087:GI5B-3885-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 5 (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 5
Gene namesi
Ordered Locus Names:Daro_3807
OrganismiDechloromonas aromatica (strain RCB)
Taxonomic identifieri159087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeDechloromonas
ProteomesiUP000000550: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Acetaldehyde dehydrogenase 5UniRule annotation
PRO_0000387657Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi159087.Daro_3807.

Structurei

3D structure databases

ProteinModelPortaliQ479E6.
SMRiQ479E6. Positions 2-293.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiAYVHRAN.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q479E6-1 [UniParc]FASTAAdd to Basket

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MKKIRCALIG SGNIGTDLIY KIQRSPVLEP VWMVGIDPES EGLARAREMG    50
LKTTAAGVDG LLPHVLEDNI QIAFDATSAY VHAENSRKLN ELGVMMIDLT 100
PAAIGPLCVP PVNLKEHTEK LEMNVNMISC AGQATIPIVH AISRIQSVSY 150
GEIVASLASK SIGPGTRANL DEFTYTTSNA IEIVGGARKG KALAIINPAD 200
PPMMMRNTIS CLTDEEPDEP RIIESVLAMI KEVQKYVPGY RLVNGPLFDG 250
KRVTVFMEVA GLGDYLPKYA GNLDIMTAAA TRTAEMFAEE ILAGTIQLKP 300
VEMAV 305
Length:305
Mass (Da):32,851
Last modified:September 13, 2005 - v1
Checksum:iFF1596BD70C4E762
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000089 Genomic DNA. Translation: AAZ48535.1.
RefSeqiYP_287005.1. NC_007298.1.

Genome annotation databases

EnsemblBacteriaiAAZ48535; AAZ48535; Daro_3807.
GeneIDi3567963.
KEGGidar:Daro_3807.
PATRICi21606304. VBIDecAro89105_3792.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000089 Genomic DNA. Translation: AAZ48535.1 .
RefSeqi YP_287005.1. NC_007298.1.

3D structure databases

ProteinModelPortali Q479E6.
SMRi Q479E6. Positions 2-293.
ModBasei Search...

Protein-protein interaction databases

STRINGi 159087.Daro_3807.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ48535 ; AAZ48535 ; Daro_3807 .
GeneIDi 3567963.
KEGGi dar:Daro_3807.
PATRICi 21606304. VBIDecAro89105_3792.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi AYVHRAN.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci DARO159087:GI5B-3885-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation."
    Salinero K.K., Keller K., Feil W.S., Feil H., Trong S., Di Bartolo G., Lapidus A.
    BMC Genomics 10:351-351(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RCB.

Entry informationi

Entry nameiACDH5_DECAR
AccessioniPrimary (citable) accession number: Q479E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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