Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetaldehyde dehydrogenase 5

Gene

Daro_3807

Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei130Acyl-thioester intermediateUniRule annotation1
Binding sitei272NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 14NADUniRule annotation4
Nucleotide bindingi161 – 169NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Enzyme and pathway databases

BioCyciDARO159087:G1G4R-3929-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 5UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 5UniRule annotation
Gene namesi
Ordered Locus Names:Daro_3807
OrganismiDechloromonas aromatica (strain RCB)
Taxonomic identifieri159087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesAzonexaceaeDechloromonas
Proteomesi
  • UP000000550 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003876571 – 305Acetaldehyde dehydrogenase 5Add BLAST305

Interactioni

Protein-protein interaction databases

STRINGi159087.Daro_3807

Structurei

3D structure databases

ProteinModelPortaliQ479E6
SMRiQ479E6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV Bacteria
COG4569 LUCA
HOGENOMiHOG000052149
KOiK18366
OMAiMIKVIRH
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

Q479E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIRCALIG SGNIGTDLIY KIQRSPVLEP VWMVGIDPES EGLARAREMG
60 70 80 90 100
LKTTAAGVDG LLPHVLEDNI QIAFDATSAY VHAENSRKLN ELGVMMIDLT
110 120 130 140 150
PAAIGPLCVP PVNLKEHTEK LEMNVNMISC AGQATIPIVH AISRIQSVSY
160 170 180 190 200
GEIVASLASK SIGPGTRANL DEFTYTTSNA IEIVGGARKG KALAIINPAD
210 220 230 240 250
PPMMMRNTIS CLTDEEPDEP RIIESVLAMI KEVQKYVPGY RLVNGPLFDG
260 270 280 290 300
KRVTVFMEVA GLGDYLPKYA GNLDIMTAAA TRTAEMFAEE ILAGTIQLKP

VEMAV
Length:305
Mass (Da):32,851
Last modified:September 13, 2005 - v1
Checksum:iFF1596BD70C4E762
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000089 Genomic DNA Translation: AAZ48535.1
RefSeqiWP_011289531.1, NC_007298.1

Genome annotation databases

EnsemblBacteriaiAAZ48535; AAZ48535; Daro_3807
KEGGidar:Daro_3807

Similar proteinsi

Entry informationi

Entry nameiACDH5_DECAR
AccessioniPrimary (citable) accession number: Q479E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: September 13, 2005
Last modified: February 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health