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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei76S-adenosyl-L-methionineUniRule annotation1
Binding sitei101S-adenosyl-L-methionineUniRule annotation1
Binding sitei128S-adenosyl-L-methionineUniRule annotation1
Active sitei151By similarity1
Binding sitei151S-adenosyl-L-methionineUniRule annotation1
Binding sitei155SubstrateUniRule annotation1
Binding sitei187SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciDARO159087:G1G4R-3985-MONOMER
UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:Daro_3860
OrganismiDechloromonas aromatica (strain RCB)
Taxonomic identifieri159087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesAzonexaceaeDechloromonas
Proteomesi
  • UP000000550 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002291631 – 246tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST246

Interactioni

Protein-protein interaction databases

STRINGi159087.Daro_3860

Structurei

3D structure databases

ProteinModelPortaliQ478Z3
SMRiQ478Z3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni157 – 162Interaction with RNAUniRule annotation6
Regioni222 – 225Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ1 Bacteria
COG0220 LUCA
HOGENOMiHOG000073968
KOiK03439
OMAiPDPWHKS
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q478Z3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTPLIQPA NVGEGVYEEG REGYGHIKSY VRRAGRMSSA QENYYAEMMP
60 70 80 90 100
KIGLVYASQP IDLAAFFGRN NPKVLEIGTG MGETTAKIAD ANRDIDYLGV
110 120 130 140 150
EVHVPGVGAL CKQIAERELT NLRICQHDAV EVVRDMLPED SLDGVHVFFP
160 170 180 190 200
DPWHKARHNK RRLIQSPFVA LLASRLKPGG YFHCATDWEE YAHQMLEVLS
210 220 230 240
GEPTLVNSSE GFAPRPDYRP LTKFENRGLR LGHGVWDVIF RKKQLA
Length:246
Mass (Da):27,622
Last modified:September 13, 2005 - v1
Checksum:i39B6364684A78E6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000089 Genomic DNA Translation: AAZ48588.1
RefSeqiWP_011289583.1, NC_007298.1

Genome annotation databases

EnsemblBacteriaiAAZ48588; AAZ48588; Daro_3860
KEGGidar:Daro_3860

Similar proteinsi

Entry informationi

Entry nameiTRMB_DECAR
AccessioniPrimary (citable) accession number: Q478Z3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 13, 2005
Last modified: February 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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