ID   AROE_DECAR              Reviewed;         274 AA.
AC   Q478U6;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 34.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=Daro_3907;
OS   Dechloromonas aromatica (strain RCB).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales;
OC   Rhodocyclaceae; Dechloromonas.
OX   NCBI_TaxID=159087;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K.,
RA   Schmutz J., Larimer F., Land M., Ivanova N., Richardson P.;
RT   "Complete sequence of Dechloromonas aromatica RCB.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; CP000089; AAZ48635.1; -; Genomic_DNA.
DR   RefSeq; YP_287105.1; -.
DR   GeneID; 3567695; -.
DR   GenomeReviews; CP000089_GR; Daro_3907.
DR   KEGG; dar:Daro_3907; -.
DR   NMPDR; fig|159087.4.peg.2939; -.
DR   HOGENOM; Q478U6; -.
DR   OMA; Q478U6; YDMMYGR.
DR   BioCyc; DARO159087:DARO_3907-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    274       Shikimate dehydrogenase.
FT                                /FTId=PRO_0000325115.
FT   NP_BIND     127    131       NADP (By similarity).
FT   ACT_SITE     66     66       Proton acceptor (Potential).
SQ   SEQUENCE   274 AA;  28198 MW;  2040424C4EE1C405 CRC64;
     MSDLYCVFGN PIAHSKSPAI HAAFAVQTAQ DLRYEARLAA LDGFGLAIAE FVAVGGKGAN
     VTVPFKEEAY RLATRLSDRA ARAGAVNTLV FDGPEVFGDN TDGAGLVRDI TNNLGFSLVG
     KRILLLGAGG ASRGVIAPLL AEKPASLIIA NRSADKAVAL AQAFADMAPL GGGSFAETAG
     KSFDLVINAT SASLSGASLP LPPGIFAPGS LAYDMMYGKG ETPFLTLARQ QGAARCADGL
     GMLVEQAAEA FFVWRGIRPG TAQVLAELRA KLVA
//