Reviewed, UniProtKB/Swiss-Prot Q478U6 (AROE_DECAR)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Daro_3907

Organism

Dechloromonas aromatica (strain RCB) [Complete proteome] [HAMAP]

Taxonomic identifier

159087 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Dechloromonas

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000325115
Regions
	Nucleotide binding	127 – 131	5	NADP By similarity
Sites
	Active site	66	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q478U6-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 2040424C4EE1C405	FASTA	274	28,198
	10 20 30 40 50 60 MSDLYCVFGN PIAHSKSPAI HAAFAVQTAQ DLRYEARLAA LDGFGLAIAE FVAVGGKGAN 70 80 90 100 110 120 VTVPFKEEAY RLATRLSDRA ARAGAVNTLV FDGPEVFGDN TDGAGLVRDI TNNLGFSLVG 130 140 150 160 170 180 KRILLLGAGG ASRGVIAPLL AEKPASLIIA NRSADKAVAL AQAFADMAPL GGGSFAETAG 190 200 210 220 230 240 KSFDLVINAT SASLSGASLP LPPGIFAPGS LAYDMMYGKG ETPFLTLARQ QGAARCADGL 250 260 270 GMLVEQAAEA FFVWRGIRPG TAQVLAELRA KLVA

References

[1]

"Complete sequence of Dechloromonas aromatica RCB." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K., Schmutz J., Larimer F., Land M., Ivanova N., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000089 Genomic DNA. Translation: AAZ48635.1.
RefSeq	YP_287105.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3567695.
GenomeReviews	Gene locus Daro_3907 in contig CP000089_GR.
KEGG	dar:Daro_3907.
NMPDR	fig|159087.4.peg.2939.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q478U6.
OMA	Q478U6. YDMMYGR.
Enzyme and pathway databases
BioCyc	DARO159087:DARO_3907-MON.
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_DECAR

Accession

Primary (citable) accession number: Q478U6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)