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Q478U2

- UPPP_DECAR

UniProt

Q478U2 - UPPP_DECAR

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciDARO159087:GI5B-3989-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Daro_3911
    OrganismiDechloromonas aromatica (strain RCB)
    Taxonomic identifieri159087 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeDechloromonas
    ProteomesiUP000000550: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 274274Undecaprenyl-diphosphatasePRO_0000227617Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi159087.Daro_3911.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalUniRule annotationAdd
    BLAST
    Transmembranei46 – 6318HelicalUniRule annotationAdd
    BLAST
    Transmembranei82 – 10221HelicalUniRule annotationAdd
    BLAST
    Transmembranei109 – 12921HelicalUniRule annotationAdd
    BLAST
    Transmembranei184 – 20421HelicalUniRule annotationAdd
    BLAST
    Transmembranei218 – 23821HelicalUniRule annotationAdd
    BLAST
    Transmembranei249 – 26921HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q478U2-1 [UniParc]FASTAAdd to Basket

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    MDPILLLKAL ILGIVEGLTE FLPISSTGHL ILAGDLLNFN DDRGKLFEIV    50
    IQSGAILAVV WEYRERLLKV ARGAFSEPAA QKFILNLFVA FLPLAILGLA 100
    FGRAIKAHLF NPVTVASTFI LGAFVILWAE RREHKIRIQT VDEMSMLDAL 150
    KLGIAQAFAL IPGTSRSGAT IIGGLLFGLS RKAATEFSFF LAIPTLIVAT 200
    FYQLYKERAL LNADDLAMWA VGFVAAFVSA FLCVRWLLRY ISTHDFTAFA 250
    WYRIAFGIVV LATWQFGWVQ WAAD 274
    Length:274
    Mass (Da):30,375
    Last modified:September 13, 2005 - v1
    Checksum:i6B9151FCB7B59C9D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000089 Genomic DNA. Translation: AAZ48639.1.
    RefSeqiYP_287109.1. NC_007298.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ48639; AAZ48639; Daro_3911.
    GeneIDi3567699.
    KEGGidar:Daro_3911.
    PATRICi21606516. VBIDecAro89105_3898.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000089 Genomic DNA. Translation: AAZ48639.1 .
    RefSeqi YP_287109.1. NC_007298.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 159087.Daro_3911.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ48639 ; AAZ48639 ; Daro_3911 .
    GeneIDi 3567699.
    KEGGi dar:Daro_3911.
    PATRICi 21606516. VBIDecAro89105_3898.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci DARO159087:GI5B-3989-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation."
      Salinero K.K., Keller K., Feil W.S., Feil H., Trong S., Di Bartolo G., Lapidus A.
      BMC Genomics 10:351-351(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RCB.

    Entry informationi

    Entry nameiUPPP_DECAR
    AccessioniPrimary (citable) accession number: Q478U2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3