Q478S1 (APAH_DECAR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
EC=3.6.1.41

Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase

Gene names

Name:	apaH
Ordered Locus Names:	Daro_3932

Organism

Dechloromonas aromatica (strain RCB) [Complete proteome] [HAMAP]

Taxonomic identifier

159087 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Dechloromonas

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity. HAMAP MF_00199
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199		PRO_1000012056

Sequences

	Sequence		Length	Mass (Da)
	Q478S1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 22367D1346D055C2	FASTA	276	30,613
	10 20 30 40 50 60 MATYAIGDIQ GCYDSLQRLL ERCAFDPASD RLWLVGDLVN RGPKSLATLR LIKSLGPAAL 70 80 90 100 110 120 TVLGNHDLYL LMVAEGGAKF RGKDDTLQEI LDAPDCAELL DWLRHQPICH TEGEYCLVHA 130 140 150 160 170 180 GLLPQWTASR ARELAREVEI TLQGPDFREF ILNLWGSEPA GWSDNLSGWA RLRVIVNAMT 190 200 210 220 230 240 RMRFCTLDGV MEFKVKGKLS NAPAGHIPWF DLPDRKSAKS VLVTGHWSAL GLKVTPNLLA 250 260 270 LDSGCLWGGH LTAVRLEDRQ VFQVDCSPTE ALPLKR

References

[1]

"Complete sequence of Dechloromonas aromatica RCB." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K., Schmutz J., Larimer F., Land M., Ivanova N., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RCB.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000089 Genomic DNA. Translation: AAZ48660.1.
RefSeq	YP_287130.1. NC_007298.1.
3D structure databases
ProteinModelPortal	Q478S1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q478S1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3567663.
GenomeReviews	Gene locus Daro_3932 in contig CP000089_GR.
KEGG	dar:Daro_3932.
NMPDR	fig|159087.4.peg.3019.
PATRIC	21606558. VBIDecAro89105_3919.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0639.
HOGENOM	HBG724457.
OMA	LVFGHWA.
PhylomeDB	Q478S1.
ProtClustDB	PRK00166.
Enzyme and pathway databases
BioCyc	DARO159087:DARO_3932-MONOMER.
Family and domain databases
HAMAP	MF_00199. ApaH. [Tree]
InterPro	IPR004617. ApaH. IPR004843. Metallo_PEstase_dom. [Graphical view]
KO	K01525.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. ApaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_DECAR

Accession

Primary (citable) accession number: Q478S1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program