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Protein

Flavastacin

Gene
N/A
Organism
Elizabethkingia meningoseptica (Chryseobacterium meningosepticum)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Zinc metallendopeptidase that cleaves preferentially on N-terminal side of aspartate-containing substrates.

Catalytic activityi

Hydrolyzes polypeptides on the amino-side of Asp in -Xaa-|-Asp-. Acts very slowly on -Xaa-|-Glu.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi189Zinc; catalyticPROSITE-ProRule annotation1
Active sitei190PROSITE-ProRule annotation1
Metal bindingi193Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi199Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Lectin, Metal-binding, Zinc

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.
MEROPSiM12.066.

Names & Taxonomyi

Protein namesi
Recommended name:
Flavastacin (EC:3.4.24.76)
OrganismiElizabethkingia meningoseptica (Chryseobacterium meningosepticum)
Taxonomic identifieri238 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeElizabethkingia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
PropeptideiPRO_000002887516 – 91Activation peptideAdd BLAST76
ChainiPRO_000002887692 – 443FlavastacinAdd BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi355O-linked (Man...)1 Publication1

Post-translational modificationi

O-linked glycan consists of the Man, GlcNAc, GlcU, Glc, GlcU, Rha, Man heptasaccharide.1 Publication

Keywords - PTMi

Glycoprotein, Zymogen

Structurei

3D structure databases

ProteinModelPortaliQ47899.
SMRiQ47899.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini297 – 440Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST144

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated
Contains 1 ricin B-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

KOiK20138.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
PF14200. RicinB_lectin_2. 1 hit.
[Graphical view]
PRINTSiPR00480. ASTACIN.
SMARTiSM00458. RICIN. 1 hit.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q47899-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRKLLILSG CLILALNSCK SDMETTPASS VDHTTTQLNG TTIHKLLING
60 70 80 90 100
AYTYVNEVNG EYFYADDITI TAEQFNQLKR MANPDISTVE RSTIVSSFIK
110 120 130 140 150
TWPNATVYYT LPSQGSLSTQ AYNTFLTNIN KAFDMISSKT SVKFVQRTNQ
160 170 180 190 200
TEYITFTYST GNSSPLGWVK NRVNGIKIYN TTYPAIIAHE IMHSMGIMHE
210 220 230 240 250
QCRPDRDQYI IVDTNRAQDG TRHNFNLYND YAGHGEFDFG SVMMYKSTDF
260 270 280 290 300
AIDPNLPVMT KLDGSTFGKQ RDGLSAGDYA GINHLYGPVN STSATNGTYT
310 320 330 340 350
LTTSLAGDKN IDITGSSTAD GTDVILYSAT TGNNQKFIFR KSEHGYFTIK
360 370 380 390 400
SILDSTKVLT VRNNGTANGT AVELRTNADT DAQKWLLFNL GNEGFGFAPK
410 420 430 440
NAPSLRLEVK DGLTTNLTPI VIGSTDQTLQ PYTKQRFTLT KVN
Length:443
Mass (Da):48,957
Last modified:November 1, 1996 - v1
Checksum:i690C6031363EFA09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37784 Genomic DNA. Translation: AAC41455.1.
PIRiS65963.

Genome annotation databases

KEGGiag:AAC41455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37784 Genomic DNA. Translation: AAC41455.1.
PIRiS65963.

3D structure databases

ProteinModelPortaliQ47899.
SMRiQ47899.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.
MEROPSiM12.066.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:AAC41455.

Phylogenomic databases

KOiK20138.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
PF14200. RicinB_lectin_2. 1 hit.
[Graphical view]
PRINTSiPR00480. ASTACIN.
SMARTiSM00458. RICIN. 1 hit.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFLVS_ELIME
AccessioniPrimary (citable) accession number: Q47899
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.