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Protein

Flavastacin

Gene
N/A
Organism
Elizabethkingia meningoseptica (Chryseobacterium meningosepticum)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Zinc metallendopeptidase that cleaves preferentially on N-terminal side of aspartate-containing substrates.

Catalytic activityi

Hydrolyzes polypeptides on the amino-side of Asp in -Xaa-|-Asp-. Acts very slowly on -Xaa-|-Glu.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi189Zinc; catalyticPROSITE-ProRule annotation1
Active sitei190PROSITE-ProRule annotation1
Metal bindingi193Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi199Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandLectin, Metal-binding, Zinc

Protein family/group databases

CAZyiCBM13 Carbohydrate-Binding Module Family 13
MEROPSiM12.066

Names & Taxonomyi

Protein namesi
Recommended name:
Flavastacin (EC:3.4.24.76)
OrganismiElizabethkingia meningoseptica (Chryseobacterium meningosepticum)
Taxonomic identifieri238 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeElizabethkingia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
PropeptideiPRO_000002887516 – 91Activation peptideAdd BLAST76
ChainiPRO_000002887692 – 443FlavastacinAdd BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi355O-linked (Man...) serine1 Publication1

Post-translational modificationi

O-linked glycan consists of the Man, GlcNAc, GlcU, Glc, GlcU, Rha, Man heptasaccharide.1 Publication

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PRIDEiQ47899

PTM databases

iPTMnetiQ47899

Structurei

3D structure databases

ProteinModelPortaliQ47899
SMRiQ47899
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini297 – 440Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST144

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK20138

Family and domain databases

CDDicd00161 RICIN, 1 hit
cd04280 ZnMc_astacin_like, 1 hit
Gene3Di3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR034035 Astacin-like_dom
IPR024079 MetalloPept_cat_dom_sf
IPR001506 Peptidase_M12A
IPR006026 Peptidase_Metallo
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PF14200 RicinB_lectin_2, 1 hit
PRINTSiPR00480 ASTACIN
SMARTiView protein in SMART
SM00458 RICIN, 1 hit
SM00235 ZnMc, 1 hit
SUPFAMiSSF50370 SSF50370, 1 hit
PROSITEiView protein in PROSITE
PS50231 RICIN_B_LECTIN, 1 hit
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q47899-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRKLLILSG CLILALNSCK SDMETTPASS VDHTTTQLNG TTIHKLLING
60 70 80 90 100
AYTYVNEVNG EYFYADDITI TAEQFNQLKR MANPDISTVE RSTIVSSFIK
110 120 130 140 150
TWPNATVYYT LPSQGSLSTQ AYNTFLTNIN KAFDMISSKT SVKFVQRTNQ
160 170 180 190 200
TEYITFTYST GNSSPLGWVK NRVNGIKIYN TTYPAIIAHE IMHSMGIMHE
210 220 230 240 250
QCRPDRDQYI IVDTNRAQDG TRHNFNLYND YAGHGEFDFG SVMMYKSTDF
260 270 280 290 300
AIDPNLPVMT KLDGSTFGKQ RDGLSAGDYA GINHLYGPVN STSATNGTYT
310 320 330 340 350
LTTSLAGDKN IDITGSSTAD GTDVILYSAT TGNNQKFIFR KSEHGYFTIK
360 370 380 390 400
SILDSTKVLT VRNNGTANGT AVELRTNADT DAQKWLLFNL GNEGFGFAPK
410 420 430 440
NAPSLRLEVK DGLTTNLTPI VIGSTDQTLQ PYTKQRFTLT KVN
Length:443
Mass (Da):48,957
Last modified:November 1, 1996 - v1
Checksum:i690C6031363EFA09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37784 Genomic DNA Translation: AAC41455.1
PIRiS65963

Genome annotation databases

KEGGiag:AAC41455

Similar proteinsi

Entry informationi

Entry nameiFLVS_ELIME
AccessioniPrimary (citable) accession number: Q47899
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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