Q47827
I6SB04
DDL_ENTHA
D-alanine--D-alanine ligase
6.3.2.4
D-Ala-D-Ala ligase
D-alanylalanine synthetase
ddl
EHR_03915
Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R)
Bacteria
Bacillota
Bacilli
Lactobacillales
Enterococcaceae
Enterococcus
Evolution of structure and substrate specificity in D-alanine:D-alanine ligases and related enzymes.
NUCLEOTIDE SEQUENCE [GENOMIC DNA]
Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790, a model organism for the study of ion transport, bioenergetics, and copper homeostasis.
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
Cell wall formation.
ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate
Mg(2+)
Mn(2+)
Binds 2 magnesium or manganese ions per subunit.
Cell wall biogenesis; peptidoglycan biosynthesis.
Cytoplasm
Belongs to the D-alanine--D-alanine ligase family.
ATP-binding
Cell shape
Cell wall biogenesis/degradation
Cytoplasm
Ligase
Magnesium
Manganese
Metal-binding
Nucleotide-binding
Peptidoglycan synthesis
Reference proteome
ATP
Mg(2+)
Mg(2+)
Mg(2+)
Mg(2+)
E
N
MKITLLYGGRSAEHDVSVLSAFSVLNAIYYTYYQVQLIFISKEGQWVKGPLLTEKPTSKEDLHLTWDPSGKVTDGFTGRVINPGEIKEEGTIVFPVLHGPNGEDGTIQGFLETLNLPYVGAGVLTSACAMDKIMTKYILQAAGVPQVPYVPVLKNQWKENPKKIFDQCEGSLLYPMFVKPANMGSSVGISKAENREELQNALALAYQYDSRAIVEQGIEAREIEVAVLGNEDVRTTLPGEVVKDVAFYDYDAKYINNKIEMQIPAEVPEEVYQKAQEYAKIAYTMLGGSGLSRCDFFLTNKNELFLNELNTMPGFTQFSMYPLLWENMGLKYGDLIEELIQLGINRFNQRQGFFEANE
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