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Q47824

- PDXA_ENTAG

UniProt

Q47824 - PDXA_ENTAG

Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Enterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).By similarity

    Catalytic activityi

    4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

    Cofactori

    Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi44 – 441Divalent metal cation; shared with dimeric partnerBy similarity
    Binding sitei52 – 521SubstrateBy similarity
    Binding sitei61 – 611SubstrateBy similarity
    Binding sitei70 – 701SubstrateBy similarity

    GO - Molecular functioni

    1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. pyridoxine biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Keywords - Ligandi

    Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00244; UER00312.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxythreonine-4-phosphate dehydrogenase (EC:1.1.1.262)
    Alternative name(s):
    4-(phosphohydroxy)-L-threonine dehydrogenase
    Gene namesi
    Name:pdxA
    OrganismiEnterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans)
    Taxonomic identifieri549 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePantoea

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 105›1054-hydroxythreonine-4-phosphate dehydrogenasePRO_0000188807Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ47824.
    SMRiQ47824. Positions 2-102.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PdxA family.Curated

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view]
    PfamiPF04166. PdxA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q47824-1 [UniParc]FASTAAdd to Basket

    « Hide

    IRILTPAVEA MKAQGMDVYG PCPPDTVFMQ CNEDMYDIVV AMYHDQGHIP    50
    LKLLGFYDGV NITAGLPFLR TSADHGTAFN IAWTGKANPE SMAISIDMAM 100
    KITRE 105
    Length:105
    Mass (Da):11,551
    Last modified:November 1, 1996 - v1
    Checksum:i749F66EE8A2A00EB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U25347 Genomic DNA. Translation: AAA66389.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U25347 Genomic DNA. Translation: AAA66389.1 .

    3D structure databases

    ProteinModelPortali Q47824.
    SMRi Q47824. Positions 2-102.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00312 .

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view ]
    Pfami PF04166. PdxA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Foor F.
      Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 21434 / AJ 2985.

    Entry informationi

    Entry nameiPDXA_ENTAG
    AccessioniPrimary (citable) accession number: Q47824
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The active site is located at the dimer interface.By similarity

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3