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Protein

Tyrosine recombinase XerC

Gene

xerC

Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei158 – 1581UniRule annotation
Active sitei193 – 1931UniRule annotation
Active sitei267 – 2671UniRule annotation
Active sitei270 – 2701UniRule annotation
Active sitei293 – 2931UniRule annotation
Active sitei302 – 3021O-(3'-phospho-DNA)-tyrosine intermediateUniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. tyrosine-based site-specific recombinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. chromosome segregation Source: UniProtKB-HAMAP
  4. transposition, DNA-mediated Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotationSAAS annotation, Chromosome partitionUniRule annotationSAAS annotation, DNA integrationUniRule annotationSAAS annotation, DNA recombinationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCPIN264198:GIW3-82-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine recombinase XerCUniRule annotation
Gene namesi
Name:xerCUniRule annotation
Ordered Locus Names:Reut_A0082Imported
OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))Imported
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002697 Componenti: Chromosome 1

Subcellular locationi

  1. Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi264198.Reut_A0082.

Structurei

3D structure databases

ProteinModelPortaliQ477G9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family. XerC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG4973.
HOGENOMiHOG000045294.
KOiK03733.
OMAiHVRVEKR.
OrthoDBiEOG6PZXFP.

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
HAMAPiMF_01808. Recomb_XerC.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat-core.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
IPR004107. Integrase_SAM-like_N.
IPR011931. Recomb_XerC.
IPR023009. Tyrosine_recombinase_XerC/XerD.
[Graphical view]
PfamiPF02899. Phage_int_SAM_1. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.
TIGRFAMsiTIGR02224. recomb_XerC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q477G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAEPTNGVT NDPIVQRYLA WLEGSRKLAG HTISSYRRDL TVLQAHAAKH
60 70 80 90 100
APGIALLALQ TRHIRAFAAR MHGEGLAGTS IARTLSAWRG FYLWAAQHGL
110 120 130 140 150
GVQANPVDGV RAPRSGHRLP KALSVEHAVA LVSHPAGTDA AALRDQAVWE
160 170 180 190 200
LFYSSGLRLA ELVQLDVRYE RLDGYESAGW LDLSGAELTV TGKGSRRRTV
210 220 230 240 250
PVGSKAMEAL RAWLGVREQL LRPGAAPEDA SALFLGARGH RLSMRVVQMR
260 270 280 290 300
LKQQAIRAGV PADVHPHMLR HSFATHMLQS SGDLRAVQEL LGHASIATTQ
310 320 330
IYTSLDFQHL AKVYDKAHPR AGRAAPSKDG SDDDETSGD
Length:339
Mass (Da):36,755
Last modified:September 13, 2005 - v1
Checksum:i6E508B89327AD4FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000090 Genomic DNA. Translation: AAZ59464.1.
RefSeqiWP_011296272.1. NC_007347.1.
YP_294308.1. NC_007347.1.

Genome annotation databases

EnsemblBacteriaiAAZ59464; AAZ59464; Reut_A0082.
KEGGireu:Reut_A0082.
PATRICi20225595. VBIRalEut24049_0676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000090 Genomic DNA. Translation: AAZ59464.1.
RefSeqiWP_011296272.1. NC_007347.1.
YP_294308.1. NC_007347.1.

3D structure databases

ProteinModelPortaliQ477G9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264198.Reut_A0082.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ59464; AAZ59464; Reut_A0082.
KEGGireu:Reut_A0082.
PATRICi20225595. VBIRalEut24049_0676.

Phylogenomic databases

eggNOGiCOG4973.
HOGENOMiHOG000045294.
KOiK03733.
OMAiHVRVEKR.
OrthoDBiEOG6PZXFP.

Enzyme and pathway databases

BioCyciCPIN264198:GIW3-82-MONOMER.

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
HAMAPiMF_01808. Recomb_XerC.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat-core.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
IPR004107. Integrase_SAM-like_N.
IPR011931. Recomb_XerC.
IPR023009. Tyrosine_recombinase_XerC/XerD.
[Graphical view]
PfamiPF02899. Phage_int_SAM_1. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.
TIGRFAMsiTIGR02224. recomb_XerC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome 1 of Ralstonia eutropha JMP134."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JMP134 / LMG 1197Imported.

Entry informationi

Entry nameiQ477G9_CUPPJ
AccessioniPrimary (citable) accession number: Q477G9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: April 1, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.