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Q477F9

- PCP_CUPPJ

UniProt

Q477F9 - PCP_CUPPJ

Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Removes 5-oxoproline from various penultimate amino acid residues except L-proline.UniRule annotation

    Catalytic activityi

    Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei80 – 801UniRule annotation
    Active sitei143 – 1431UniRule annotation
    Active sitei168 – 1681UniRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Enzyme and pathway databases

    BioCyciCPIN264198:GIW3-92-MONOMER.

    Protein family/group databases

    MEROPSiC15.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyrrolidone-carboxylate peptidaseUniRule annotation (EC:3.4.19.3UniRule annotation)
    Alternative name(s):
    5-oxoprolyl-peptidaseUniRule annotation
    Pyroglutamyl-peptidase IUniRule annotation
    Short name:
    PGP-IUniRule annotation
    Short name:
    PyraseUniRule annotation
    Gene namesi
    Name:pcpUniRule annotation
    Ordered Locus Names:Reut_A0092
    OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
    Taxonomic identifieri264198 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000002697: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 216216Pyrrolidone-carboxylate peptidasePRO_1000050136Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi264198.Reut_A0092.

    Structurei

    3D structure databases

    ProteinModelPortaliQ477F9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C15 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2039.
    HOGENOMiHOG000242641.
    KOiK01304.
    OMAiKPNTPSM.
    OrthoDBiEOG6X1124.

    Family and domain databases

    Gene3Di3.40.630.20. 1 hit.
    HAMAPiMF_00417. Pyrrolid_peptidase.
    InterProiIPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view]
    PANTHERiPTHR23402. PTHR23402. 1 hit.
    PfamiPF01470. Peptidase_C15. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSiPR00706. PYROGLUPTASE.
    PROSITEiPS01334. PYRASE_CYS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q477F9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTVLLTGFE PFENEPINPS WEAVRALDGE RIGDAVVVAR QLPCVFGAAI    50
    DGMAALLREL KPAIAIAVGQ AGGRTEMSVE RVAINVDDAR IADNAGAQPI 100
    DTVIAAKGPA AYFSTLPIKA IVRDMRAAGV PAAVSQTAGT FVCNHVFYGL 150
    MHALATPAGE GVRGGFIHIP YLPEQAARHP GEASMSLESM VRGIRQAIAT 200
    TLATEVDVRE QGGQLH 216
    Length:216
    Mass (Da):22,706
    Last modified:September 13, 2005 - v1
    Checksum:iBFCD0854BD2CD482
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000090 Genomic DNA. Translation: AAZ59474.1.
    RefSeqiYP_294318.1. NC_007347.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ59474; AAZ59474; Reut_A0092.
    GeneIDi3611158.
    KEGGireu:Reut_A0092.
    PATRICi20225617. VBIRalEut24049_0687.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000090 Genomic DNA. Translation: AAZ59474.1 .
    RefSeqi YP_294318.1. NC_007347.1.

    3D structure databases

    ProteinModelPortali Q477F9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264198.Reut_A0092.

    Protein family/group databases

    MEROPSi C15.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ59474 ; AAZ59474 ; Reut_A0092 .
    GeneIDi 3611158.
    KEGGi reu:Reut_A0092.
    PATRICi 20225617. VBIRalEut24049_0687.

    Phylogenomic databases

    eggNOGi COG2039.
    HOGENOMi HOG000242641.
    KOi K01304.
    OMAi KPNTPSM.
    OrthoDBi EOG6X1124.

    Enzyme and pathway databases

    BioCyci CPIN264198:GIW3-92-MONOMER.

    Family and domain databases

    Gene3Di 3.40.630.20. 1 hit.
    HAMAPi MF_00417. Pyrrolid_peptidase.
    InterProi IPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view ]
    PANTHERi PTHR23402. PTHR23402. 1 hit.
    Pfami PF01470. Peptidase_C15. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSi PR00706. PYROGLUPTASE.
    PROSITEi PS01334. PYRASE_CYS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Ralstonia eutropha JMP134."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JMP134 / LMG 1197.

    Entry informationi

    Entry nameiPCP_CUPPJ
    AccessioniPrimary (citable) accession number: Q477F9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3