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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:Reut_A0127
OrganismiCupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000002697 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002420751 – 595Arginine--tRNA ligaseAdd BLAST595

Proteomic databases

PRIDEiQ477C4

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi264198.Reut_A0127

Structurei

3D structure databases

ProteinModelPortaliQ477C4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi132 – 142"HIGH" regionAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C75 Bacteria
COG0018 LUCA
HOGENOMiHOG000247214
KOiK01887
OMAiNKPLHLG
OrthoDBiPOG091H01RF

Family and domain databases

CDDicd00671 ArgRS_core, 1 hit
Gene3Di3.30.1360.70, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00123 Arg_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR005148 Arg-tRNA-synth_N
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956 PTHR11956, 1 hit
PfamiView protein in Pfam
PF03485 Arg_tRNA_synt_N, 1 hit
PF05746 DALR_1, 1 hit
PF00750 tRNA-synt_1d, 1 hit
PRINTSiPR01038 TRNASYNTHARG
SMARTiView protein in SMART
SM01016 Arg_tRNA_synt_N, 1 hit
SM00836 DALR_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF55190 SSF55190, 1 hit
TIGRFAMsiTIGR00456 argS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q477C4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPVQTSNLA AAFTDAVRAL APADAALPAV TFERPKAAAH GDLACNIAMQ
60 70 80 90 100
VARALKSNPR ELAQRIVAMV QADPRAAELV AGMEIAGPGF INLRLTPAAK
110 120 130 140 150
ADVLRAVLSE GDGYGAQERG MHGNVLVEFV SANPTGPLHV GHGRQAALGD
160 170 180 190 200
ALANLLSWQG YDVHREFYYN DAGVQIQNLA VSVQARTRGF KPGDANWPEA
210 220 230 240 250
AYNGDYIGDI AADFLAGKTV SASDGEPVTA SGNPEDLDSI RKFAVTYLRN
260 270 280 290 300
EQDIDLQAFG VKFDHYYLES SLYTDGRVEA AVQGLVGKGK TYESEGALWL
310 320 330 340 350
RTTDDGDDKD RVMKKTDGTY TYFVPDVAYH TTKWERGFTK VINVQGSDHH
360 370 380 390 400
GTIARVRAGL QGLDIGIPKG YPDYVLHKMV TVMKNGEEVK ISKRAGSYVT
410 420 430 440 450
VRDLIEWSNG GDETIRGCLD AGVADWPEHF TRGRDAVRFF LLSRKADTEF
460 470 480 490 500
VFDVDLALKQ NDENPVYYVQ YAHARICSIF ESWGGADWES RLAELAGTDL
510 520 530 540 550
AAVTGADASP QALALGQRLA EFPEMLAAAA GELAPHAVAF YLRDLAGDFH
560 570 580 590
AFYNADRVLV DDEAVKRARL ALLAATRQVL RNGLAVIGVS APRRM
Length:595
Mass (Da):64,495
Last modified:September 13, 2005 - v1
Checksum:i645BD50B6A69D79E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000090 Genomic DNA Translation: AAZ59509.1
RefSeqiWP_011296317.1, NC_007347.1

Genome annotation databases

EnsemblBacteriaiAAZ59509; AAZ59509; Reut_A0127
KEGGireu:Reut_A0127

Similar proteinsi

Entry informationi

Entry nameiSYR_CUPNJ
AccessioniPrimary (citable) accession number: Q477C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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