Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Enterococcus faecium (Streptococcus faecium)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 2 magnesium or manganese ions per subunit.UniRule annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi295Magnesium or manganese 1UniRule annotation1
Metal bindingi308Magnesium or manganese 1UniRule annotation1
Metal bindingi308Magnesium or manganese 2UniRule annotation1
Metal bindingi310Magnesium or manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotationImported
ORF Names:A5804_000221Imported, A5810_001545Imported, A5814_000255Imported, A5836_000927Imported, A5841_000231Imported, A5860_001648Imported, AS238_02515Imported, AWT83_02645Imported, B4W81_03435Imported, BTA13_13995Imported, BU184_05805Imported, BU186_09275Imported, BU187_03370Imported, BU188_02290Imported, BU190_13195Imported, BU191_12780Imported, BU192_11080Imported, BU194_14710Imported, CI258_14230Imported, CKY17_08485Imported, CQR38_07495Imported, CQR40_05085Imported, CRM75_04840Imported, CX663_00970Imported, DTPHA_601969Imported, HMPREF3199_01742Imported
OrganismiEnterococcus faecium (Streptococcus faecium)Imported
Taxonomic identifieri1352 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000195616 Componenti: Unassembled WGS sequence
  • UP000195870 Componenti: Unassembled WGS sequence
  • UP000070452 Componenti: Unassembled WGS sequence
  • UP000183509 Componenti: Unassembled WGS sequence
  • UP000194579 Componenti: Unassembled WGS sequence
  • UP000070567 Componenti: Unassembled WGS sequence
  • UP000194609 Componenti: Unassembled WGS sequence
  • UP000195760 Componenti: Unassembled WGS sequence
  • UP000221153 Componenti: Unassembled WGS sequence
  • UP000223717 Componenti: Unassembled WGS sequence
  • UP000194737 Componenti: Unassembled WGS sequence
  • UP000196256 Componenti: Unassembled WGS sequence
  • UP000195680 Componenti: Unassembled WGS sequence
  • UP000234558 Componenti: Chromosome
  • UP000220448 Componenti: Unassembled WGS sequence
  • UP000195292 Componenti: Unassembled WGS sequence
  • UP000195180 Componenti: Unassembled WGS sequence
  • UP000194885 Componenti: Unassembled WGS sequence
  • UP000221491 Componenti: Unassembled WGS sequence
  • UP000195317 Componenti: Unassembled WGS sequence
  • UP000194755 Componenti: Unassembled WGS sequence
  • UP000190755 Componenti: Chromosome
  • UP000225744 Componenti: Unassembled WGS sequence
  • UP000070534 Componenti: Unassembled WGS sequence
  • UP000218403 Componenti: Unassembled WGS sequence
  • UP000195596 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 341ATP-graspInterPro annotationAdd BLAST206

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CPF Bacteria
COG1181 LUCA

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PIRSFiPIRSF039102 Ddl/VanB, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q47755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITLLYGGR SAEHEVSILS AFSVLNAIYY NYYQVQLVFI TKEGQWVKGP
60 70 80 90 100
LLTEKPASKD VLHLSWDPSG QTEEGFTGKV INPGEIKEEG AIVFPVLHGP
110 120 130 140 150
NGEDGTIQGF LETLNMPYVG AGVLTSACAM DKIMTKYILQ AAGVPQVPYV
160 170 180 190 200
PVLKNQWKEN PKKVFDQCEG SLLYPMFVKP ANMGSSVGIT KAENREELQN
210 220 230 240 250
ALATAYQYDS RAIVEQGIEA REIEVAVLGN EDVRTTLPGE VVKDVAFYDY
260 270 280 290 300
EAKYINNKIE MQIPAEVPEE VYQKAQEYAK LAYTMLGGSG LSRCDFFLTN
310 320 330 340 350
KNELFLNELN SMPGFTEFSM YPLLWENMGL KYGDLIEELI QLGMNRYHQR

QSFFEKNE
Length:358
Mass (Da):40,247
Last modified:June 1, 2001 - v2
Checksum:i0801F31DB1FA9FEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39790 Genomic DNA Translation: AAB17902.2
AF550665 Genomic DNA Translation: AAQ12892.1
KF823966 Genomic DNA Translation: AHH83929.1
CP019992 Genomic DNA Translation: AQY31119.1
CP025425 Genomic DNA Translation: AUH46478.1
LRHK01000001 Genomic DNA Translation: KWX17459.1
LNLS01000203 Genomic DNA Translation: KWY38227.1
LRPV01000094 Genomic DNA Translation: KXA08059.1
NGKW01000003 Genomic DNA Translation: OTN93669.1
NGLB01000001 Genomic DNA Translation: OTN98738.1
NGLR01000001 Genomic DNA Translation: OTO45367.1
NGLS01000001 Genomic DNA Translation: OTO52172.1
NGMI01000001 Genomic DNA Translation: OTO98360.1
NGMJ01000002 Genomic DNA Translation: OTO99906.1
MSHV01000021 Genomic DNA Translation: OUK16642.1
MSHX01000113 Genomic DNA Translation: OUK21048.1
MSHY01000145 Genomic DNA Translation: OUK27142.1
MSHZ01000132 Genomic DNA Translation: OUK27258.1
MSIB01000054 Genomic DNA Translation: OUK36276.1
MSIA01000017 Genomic DNA Translation: OUK38336.1
MSID01000212 Genomic DNA Translation: OUK39601.1
MSIC01000189 Genomic DNA Translation: OUK40360.1
NSDF01000038 Genomic DNA Translation: PCE11828.1
PDEC01000006 Genomic DNA Translation: PEH47275.1
NPOO01000201 Genomic DNA Translation: PHI41857.1
PCFZ01000006 Genomic DNA Translation: PHL13477.1
PCGB01000005 Genomic DNA Translation: PHL15821.1
NXPI01000105 Genomic DNA Translation: PHL87125.1
FKLM01000037 Genomic DNA Translation: SAM48702.1
RefSeqiWP_002293424.1, NZ_PUBN01000068.1

Genome annotation databases

EnsemblBacteriaiKWX17459; KWX17459; AWT83_02645
KWY38227; KWY38227; AS238_02515
KWY85153; KWY85153; AS252_05080
KXA08059; KXA08059; HMPREF3199_01742
PATRICifig|1352.655.peg.1326

Similar proteinsi

Entry informationi

Entry nameiQ47755_ENTFC
AccessioniPrimary (citable) accession number: Q47755
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health