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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Enterococcus faecium (Streptococcus faecium)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 2 magnesium or manganese ions per subunit.UniRule annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi295Magnesium or manganese 1UniRule annotation1
Metal bindingi308Magnesium or manganese 1UniRule annotation1
Metal bindingi308Magnesium or manganese 2UniRule annotation1
Metal bindingi310Magnesium or manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotationImported
ORF Names:A5805_000358Imported, A5810_001545Imported, A5812_000341Imported, A5813_001831Imported, A5814_000255Imported, A5815_000860Imported, A5827_000184Imported, A5832_000231Imported, A5834_001159Imported, A5836_000927Imported, A5837_000352Imported, A5839_002496Imported, A5841_000231Imported, A5842_000933Imported, A5845_000692Imported, A5853_000691Imported, A5856_001012Imported, A5858_000195Imported, A5860_001648Imported, A5872_002214Imported, A5873_000358Imported, A5874_002145Imported, A5887_001223Imported, AS238_02515Imported, AS252_05080Imported, AWT83_02645Imported, BTN89_05990Imported, BU184_05805Imported, BU186_09275Imported, BU187_03370Imported, BU188_02290Imported, BU190_13195Imported, BU191_12780Imported, BU192_11080Imported, BU194_14710Imported, HMPREF3199_01742Imported
OrganismiEnterococcus faecium (Streptococcus faecium)Imported
Taxonomic identifieri1352 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000188517 Componenti: Unassembled WGS sequence
  • UP000195616 Componenti: Unassembled WGS sequence
  • UP000194552 Componenti: Unassembled WGS sequence
  • UP000195870 Componenti: Unassembled WGS sequence
  • UP000194743 Componenti: Unassembled WGS sequence
  • UP000070452 Componenti: Unassembled WGS sequence
  • UP000194881 Componenti: Unassembled WGS sequence
  • UP000194579 Componenti: Unassembled WGS sequence
  • UP000070567 Componenti: Unassembled WGS sequence
  • UP000195015 Componenti: Unassembled WGS sequence
  • UP000196601 Componenti: Unassembled WGS sequence
  • UP000194745 Componenti: Unassembled WGS sequence
  • UP000194609 Componenti: Unassembled WGS sequence
  • UP000195760 Componenti: Unassembled WGS sequence
  • UP000195416 Componenti: Unassembled WGS sequence
  • UP000194781 Componenti: Unassembled WGS sequence
  • UP000194982 Componenti: Unassembled WGS sequence
  • UP000195539 Componenti: Unassembled WGS sequence
  • UP000196256 Componenti: Unassembled WGS sequence
  • UP000194984 Componenti: Unassembled WGS sequence
  • UP000195680 Componenti: Unassembled WGS sequence
  • UP000195413 Componenti: Unassembled WGS sequence
  • UP000194994 Componenti: Unassembled WGS sequence
  • UP000195292 Componenti: Unassembled WGS sequence
  • UP000195180 Componenti: Unassembled WGS sequence
  • UP000194885 Componenti: Unassembled WGS sequence
  • UP000195317 Componenti: Unassembled WGS sequence
  • UP000195097 Componenti: Unassembled WGS sequence
  • UP000194863 Componenti: Unassembled WGS sequence
  • UP000194755 Componenti: Unassembled WGS sequence
  • UP000194845 Componenti: Unassembled WGS sequence
  • UP000195223 Componenti: Unassembled WGS sequence
  • UP000070534 Componenti: Unassembled WGS sequence
  • UP000070236 Componenti: Unassembled WGS sequence
  • UP000194747 Componenti: Unassembled WGS sequence
  • UP000195596 Componenti: Unassembled WGS sequence

Subcellular locationi

Q47755:
  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 341ATP-graspInterPro annotationAdd BLAST206

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CPF. Bacteria.
COG1181. LUCA.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PIRSFiPIRSF039102. Ddl/VanB. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITLLYGGR SAEHEVSILS AFSVLNAIYY NYYQVQLVFI TKEGQWVKGP
60 70 80 90 100
LLTEKPASKD VLHLSWDPSG QTEEGFTGKV INPGEIKEEG AIVFPVLHGP
110 120 130 140 150
NGEDGTIQGF LETLNMPYVG AGVLTSACAM DKIMTKYILQ AAGVPQVPYV
160 170 180 190 200
PVLKNQWKEN PKKVFDQCEG SLLYPMFVKP ANMGSSVGIT KAENREELQN
210 220 230 240 250
ALATAYQYDS RAIVEQGIEA REIEVAVLGN EDVRTTLPGE VVKDVAFYDY
260 270 280 290 300
EAKYINNKIE MQIPAEVPEE VYQKAQEYAK LAYTMLGGSG LSRCDFFLTN
310 320 330 340 350
KNELFLNELN SMPGFTEFSM YPLLWENMGL KYGDLIEELI QLGMNRYHQR

QSFFEKNE
Length:358
Mass (Da):40,247
Last modified:June 1, 2001 - v2
Checksum:i0801F31DB1FA9FEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39790 Genomic DNA. Translation: AAB17902.2.
AF550665 Genomic DNA. Translation: AAQ12892.1.
KF823966 Genomic DNA. Translation: AHH83929.1.
LRHK01000001 Genomic DNA. Translation: KWX17459.1.
LNLS01000203 Genomic DNA. Translation: KWY38227.1.
LNMG01000038 Genomic DNA. Translation: KWY85153.1.
LRPV01000094 Genomic DNA. Translation: KXA08059.1.
MRYF01000010 Genomic DNA. Translation: ONN40847.1.
NGKR01000001 Genomic DNA. Translation: OTN69824.1.
NGKT01000001 Genomic DNA. Translation: OTN73137.1.
NGKW01000003 Genomic DNA. Translation: OTN93669.1.
NGLA01000001 Genomic DNA. Translation: OTN96735.1.
NGLM01000002 Genomic DNA. Translation: OTO40430.1.
NGLO01000001 Genomic DNA. Translation: OTO40844.1.
NGLR01000001 Genomic DNA. Translation: OTO45367.1.
NGLP01000005 Genomic DNA. Translation: OTO49711.1.
NGLS01000001 Genomic DNA. Translation: OTO52172.1.
NGLT01000001 Genomic DNA. Translation: OTO56347.1.
NGLW01000001 Genomic DNA. Translation: OTO59552.1.
NGLU01000001 Genomic DNA. Translation: OTO61435.1.
NGLV01000001 Genomic DNA. Translation: OTO63888.1.
NGLX01000001 Genomic DNA. Translation: OTO66568.1.
NGMB01000001 Genomic DNA. Translation: OTO73791.1.
NGMC01000001 Genomic DNA. Translation: OTO80641.1.
NGMH01000001 Genomic DNA. Translation: OTO92440.1.
NGMI01000001 Genomic DNA. Translation: OTO98360.1.
NGMJ01000002 Genomic DNA. Translation: OTO99906.1.
NGML01000001 Genomic DNA. Translation: OTP01576.1.
NGMK01000001 Genomic DNA. Translation: OTP05265.1.
MSHV01000021 Genomic DNA. Translation: OUK16642.1.
MSHX01000113 Genomic DNA. Translation: OUK21048.1.
MSHY01000145 Genomic DNA. Translation: OUK27142.1.
MSHZ01000132 Genomic DNA. Translation: OUK27258.1.
MSIB01000054 Genomic DNA. Translation: OUK36276.1.
MSIA01000017 Genomic DNA. Translation: OUK38336.1.
MSID01000212 Genomic DNA. Translation: OUK39601.1.
MSIC01000189 Genomic DNA. Translation: OUK40360.1.
NIBM01000003 Genomic DNA. Translation: OUZ20344.1.
NIBJ01000001 Genomic DNA. Translation: OUZ27647.1.
RefSeqiWP_002293424.1. NZ_NIBM01000003.1.

Genome annotation databases

EnsemblBacteriaiKWX17459; KWX17459; AWT83_02645.
KWY38227; KWY38227; AS238_02515.
KWY85153; KWY85153; AS252_05080.
KXA08059; KXA08059; HMPREF3199_01742.
PATRICifig|1352.655.peg.1326.

Similar proteinsi

Entry informationi

Entry nameiQ47755_ENTFC
AccessioniPrimary (citable) accession number: Q47755
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported