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Protein

Membrane-associated protein UidC

Gene

uidC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the activity of the UidB (GusB) glucuronide transporter, on its own however it has no transport activity. Glucuronide transport does not occur in strain K12 due to a variant at position 100 of the UidB (GusB, AC P0CE44, AC P0CE45) protein.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G6866-MONOMER.
ECOL316407:JW1607-MONOMER.

Protein family/group databases

TCDBi1.B.25.1.5. the outer membrane porin (opr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated protein UidC
Gene namesi
Name:uidC
Synonyms:gusC
Ordered Locus Names:b1615, JW1607
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12668. uidC.

Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc
  • pore complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 421398Membrane-associated protein UidCPRO_0000022625Add
BLAST

Proteomic databases

PaxDbiQ47706.

Expressioni

Inductioni

In the presence of glucuronides.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261073. 178 interactions.
DIPiDIP-11088N.
IntActiQ47706. 6 interactions.
MINTiMINT-1299860.
STRINGi511145.b1615.

Structurei

3D structure databases

ProteinModelPortaliQ47706.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4108QNI. Bacteria.
ENOG410XU8G. LUCA.
HOGENOMiHOG000120875.
KOiK16140.
OMAiYDAILYY.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR005318. OM_porin_bac.
IPR023614. Porin_dom.
[Graphical view]
PfamiPF03573. OprD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q47706-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKIVAMAVI CLTAASGLTS AYAAQLADDE AGLRIRLKNE LRRADKPSAG
60 70 80 90 100
AGRDIYAWVQ GGLLDFNSGY YSNIIGVEGG AYYVYKLGAR ADMSTRWYLD
110 120 130 140 150
GDKSFGFALG AVKIKPSENS LLKLGRFGTD YSYGSLPYRI PLMAGSSQRT
160 170 180 190 200
LPTVSEGALG YWALTPNIDL WGMWRSRVFL WTDSTTGIRD EGVYNSQTGK
210 220 230 240 250
YDKHRARSFL AASWHDDTSR YSLGASVQKD VSNQIQSILE KSIPLDPNYT
260 270 280 290 300
LKGELLGFYA QLEGLSRNTS QPNETALVSG QLTWNAPWGS VFGSGGYLRH
310 320 330 340 350
AMNGAVVDTD IGYPFSLSLD RNREGMQSWQ LGVNYRLTPQ FTLTFAPIVT
360 370 380 390 400
RGYESSKRDV RIEGTGILGG MNYRVSEGPL QGMNFFLAAD KGREKRDGST
410 420
LGDRLNYWDV KMSIQYDFML K
Length:421
Mass (Da):46,648
Last modified:June 27, 2006 - v3
Checksum:iE900FEBF9FE1C7EE
GO

Sequence cautioni

The sequence AAA68925 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1094GFAL → ALP in AAA68925 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14641 Genomic DNA. Translation: AAA68925.1. Different initiation.
U00096 Genomic DNA. Translation: AAC74687.2.
AP009048 Genomic DNA. Translation: BAE76482.1.
PIRiA64918.
RefSeqiNP_416132.2. NC_000913.3.
WP_001227023.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74687; AAC74687; b1615.
BAE76482; BAE76482; BAE76482.
GeneIDi944820.
KEGGiecj:JW1607.
eco:b1615.
PATRICi32118532. VBIEscCol129921_1686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14641 Genomic DNA. Translation: AAA68925.1. Different initiation.
U00096 Genomic DNA. Translation: AAC74687.2.
AP009048 Genomic DNA. Translation: BAE76482.1.
PIRiA64918.
RefSeqiNP_416132.2. NC_000913.3.
WP_001227023.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliQ47706.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261073. 178 interactions.
DIPiDIP-11088N.
IntActiQ47706. 6 interactions.
MINTiMINT-1299860.
STRINGi511145.b1615.

Protein family/group databases

TCDBi1.B.25.1.5. the outer membrane porin (opr) family.

Proteomic databases

PaxDbiQ47706.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74687; AAC74687; b1615.
BAE76482; BAE76482; BAE76482.
GeneIDi944820.
KEGGiecj:JW1607.
eco:b1615.
PATRICi32118532. VBIEscCol129921_1686.

Organism-specific databases

EchoBASEiEB2534.
EcoGeneiEG12668. uidC.

Phylogenomic databases

eggNOGiENOG4108QNI. Bacteria.
ENOG410XU8G. LUCA.
HOGENOMiHOG000120875.
KOiK16140.
OMAiYDAILYY.

Enzyme and pathway databases

BioCyciEcoCyc:G6866-MONOMER.
ECOL316407:JW1607-MONOMER.

Miscellaneous databases

PROiQ47706.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR005318. OM_porin_bac.
IPR023614. Porin_dom.
[Graphical view]
PfamiPF03573. OprD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUIDC_ECOLI
AccessioniPrimary (citable) accession number: Q47706
Secondary accession number(s): P76178, Q2MB74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 27, 2006
Last modified: September 7, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.