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Protein

Cytochrome c oxidase subunit 1

Gene

Reut_A0315

Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

CopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

BioCyciREUT264198:G12XR-316-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Ordered Locus Names:Reut_A0315Imported
OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))Imported
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000002697 Componenti: Chromosome 1

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 63HelicalUniRule annotationAdd BLAST22
Transmembranei83 – 104HelicalUniRule annotationAdd BLAST22
Transmembranei125 – 148HelicalUniRule annotationAdd BLAST24
Transmembranei168 – 192HelicalUniRule annotationAdd BLAST25
Transmembranei204 – 231HelicalUniRule annotationAdd BLAST28
Transmembranei251 – 275HelicalUniRule annotationAdd BLAST25
Transmembranei287 – 311HelicalUniRule annotationAdd BLAST25
Transmembranei323 – 345HelicalUniRule annotationAdd BLAST23
Transmembranei357 – 377HelicalUniRule annotationAdd BLAST21
Transmembranei397 – 416HelicalUniRule annotationAdd BLAST20
Transmembranei432 – 452HelicalUniRule annotationAdd BLAST21
Transmembranei472 – 494HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Protein-protein interaction databases

STRINGi264198.Reut_A0315.

Structurei

3D structure databases

ProteinModelPortaliQ476I6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 534COX1InterPro annotationAdd BLAST505

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000085274.
KOiK02274.
OMAiPYHTFEE.
OrthoDBiPOG091H042R.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q476I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTATPDAIG HPHDHAHDHA HDHPHGWRRW LFATNHKDIG TLYLLFAFIM
60 70 80 90 100
LLSGGLLALL IRLELFEPGL QFFRPELFNQ FTTMHGLIMV FGAIMPAFVG
110 120 130 140 150
FANWMIPLQI GASDMAFARM NNFSFWLMPP AALLLAGSFF APGGATAAGW
160 170 180 190 200
TLYAPLSVQM GPGMDMAIFA MHIMGASSIM GSINIIVTIL NMRAPGMTLM
210 220 230 240 250
KMPMFCWTWL ITAYLLIAVM PVLAGAITMV LTDRHFGTSF FSAAGGGDPV
260 270 280 290 300
MYQHIFWFFG HPEVYIMILP AFGIISQVVP AFARKRLFGY SSMVYATASI
310 320 330 340 350
AILSFIVWAH HMFTTGMPVT GQLFFMYATM LIAVPTAVKI FNWIATMWRG
360 370 380 390 400
SMTFETPMLF SIGFIFVFTI GGFTGLMPAV APIDIQLQDT YFIVAHFHYV
410 420 430 440 450
LVAGSLFALF AGFYYWGPKW SGFMYNETRG QIHFWGSIIF FNVTFFPMHF
460 470 480 490 500
LGLAGMPRRY ADYPTQFADF NAIASIGALG FGLMQVYFFF FVVLPSYRGG
510 520 530
EKAADKPWEG AEGLEWTVPS PAPFHTFEVP PQVR
Length:534
Mass (Da):59,634
Last modified:September 13, 2005 - v1
Checksum:iF44EC674C2B94404
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000090 Genomic DNA. Translation: AAZ59697.1.
RefSeqiWP_011296505.1. NC_007347.1.

Genome annotation databases

EnsemblBacteriaiAAZ59697; AAZ59697; Reut_A0315.
KEGGireu:Reut_A0315.
PATRICi20226071. VBIRalEut24049_0913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000090 Genomic DNA. Translation: AAZ59697.1.
RefSeqiWP_011296505.1. NC_007347.1.

3D structure databases

ProteinModelPortaliQ476I6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264198.Reut_A0315.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ59697; AAZ59697; Reut_A0315.
KEGGireu:Reut_A0315.
PATRICi20226071. VBIRalEut24049_0913.

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000085274.
KOiK02274.
OMAiPYHTFEE.
OrthoDBiPOG091H042R.

Enzyme and pathway databases

UniPathwayiUPA00705.
BioCyciREUT264198:G12XR-316-MONOMER.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ476I6_CUPPJ
AccessioniPrimary (citable) accession number: Q476I6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: November 30, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.