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Protein

Cytochrome c oxidase subunit 1

Gene

Reut_A0315

Organism
Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Ordered Locus Names:Reut_A0315Imported
OrganismiCupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))Imported
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000002697 Componenti: Chromosome 1

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 63HelicalUniRule annotationAdd BLAST22
Transmembranei83 – 104HelicalUniRule annotationAdd BLAST22
Transmembranei125 – 148HelicalUniRule annotationAdd BLAST24
Transmembranei168 – 192HelicalUniRule annotationAdd BLAST25
Transmembranei204 – 231HelicalUniRule annotationAdd BLAST28
Transmembranei251 – 275HelicalUniRule annotationAdd BLAST25
Transmembranei287 – 311HelicalUniRule annotationAdd BLAST25
Transmembranei323 – 345HelicalUniRule annotationAdd BLAST23
Transmembranei357 – 377HelicalUniRule annotationAdd BLAST21
Transmembranei397 – 416HelicalUniRule annotationAdd BLAST20
Transmembranei432 – 452HelicalUniRule annotationAdd BLAST21
Transmembranei472 – 494HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Protein-protein interaction databases

STRINGi264198.Reut_A0315

Structurei

3D structure databases

ProteinModelPortaliQ476I6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 534COX1InterPro annotationAdd BLAST505

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZ9 Bacteria
COG0843 LUCA
HOGENOMiHOG000085274
KOiK02274
OMAiPVDFQYH
OrthoDBiPOG091H042R

Family and domain databases

CDDicd01663 Cyt_c_Oxidase_I, 1 hit
Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
IPR033944 Cyt_c_oxase_su1_dom
IPR014241 Cyt_c_oxidase_su1_bac
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
TIGRFAMsiTIGR02891 CtaD_CoxA, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

Q476I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTATPDAIG HPHDHAHDHA HDHPHGWRRW LFATNHKDIG TLYLLFAFIM
60 70 80 90 100
LLSGGLLALL IRLELFEPGL QFFRPELFNQ FTTMHGLIMV FGAIMPAFVG
110 120 130 140 150
FANWMIPLQI GASDMAFARM NNFSFWLMPP AALLLAGSFF APGGATAAGW
160 170 180 190 200
TLYAPLSVQM GPGMDMAIFA MHIMGASSIM GSINIIVTIL NMRAPGMTLM
210 220 230 240 250
KMPMFCWTWL ITAYLLIAVM PVLAGAITMV LTDRHFGTSF FSAAGGGDPV
260 270 280 290 300
MYQHIFWFFG HPEVYIMILP AFGIISQVVP AFARKRLFGY SSMVYATASI
310 320 330 340 350
AILSFIVWAH HMFTTGMPVT GQLFFMYATM LIAVPTAVKI FNWIATMWRG
360 370 380 390 400
SMTFETPMLF SIGFIFVFTI GGFTGLMPAV APIDIQLQDT YFIVAHFHYV
410 420 430 440 450
LVAGSLFALF AGFYYWGPKW SGFMYNETRG QIHFWGSIIF FNVTFFPMHF
460 470 480 490 500
LGLAGMPRRY ADYPTQFADF NAIASIGALG FGLMQVYFFF FVVLPSYRGG
510 520 530
EKAADKPWEG AEGLEWTVPS PAPFHTFEVP PQVR
Length:534
Mass (Da):59,634
Last modified:September 13, 2005 - v1
Checksum:iF44EC674C2B94404
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000090 Genomic DNA Translation: AAZ59697.1
RefSeqiWP_011296505.1, NC_007347.1

Genome annotation databases

EnsemblBacteriaiAAZ59697; AAZ59697; Reut_A0315
KEGGireu:Reut_A0315

Similar proteinsi

Entry informationi

Entry nameiQ476I6_CUPNJ
AccessioniPrimary (citable) accession number: Q476I6
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health