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Protein

Probable S-methylmethionine permease

Gene

mmuP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transporter for the intake of S-methylmethionine.

GO - Molecular functioni

  • antiporter activity Source: GO_Central
  • L-amino acid transmembrane transporter activity Source: GO_Central
  • S-methylmethionine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • methionine biosynthetic process Source: EcoCyc
  • S-methylmethionine transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:B0260-MONOMER.
ECOL316407:JW5027-MONOMER.
MetaCyc:B0260-MONOMER.

Protein family/group databases

TCDBi2.A.3.1.10. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable S-methylmethionine permease
Gene namesi
Name:mmuP
Synonyms:ykfD
Ordered Locus Names:b0260, JW5027
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13342. mmuP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence analysisAdd
BLAST
Transmembranei43 – 6321HelicalSequence analysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence analysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence analysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence analysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence analysisAdd
BLAST
Transmembranei245 – 26521HelicalSequence analysisAdd
BLAST
Transmembranei282 – 30221HelicalSequence analysisAdd
BLAST
Transmembranei337 – 35721HelicalSequence analysisAdd
BLAST
Transmembranei361 – 38121HelicalSequence analysisAdd
BLAST
Transmembranei408 – 42821HelicalSequence analysisAdd
BLAST
Transmembranei434 – 45421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Probable S-methylmethionine permeasePRO_0000054205Add
BLAST

Proteomic databases

PaxDbiQ47689.

Interactioni

Protein-protein interaction databases

BioGridi4259776. 11 interactions.
STRINGi511145.b0260.

Structurei

3D structure databases

ProteinModelPortaliQ47689.
SMRiQ47689. Positions 25-425.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108IQI. Bacteria.
COG0833. LUCA.
HOGENOMiHOG000261850.
InParanoidiQ47689.
KOiK16235.
OMAiCASHYVF.
PhylomeDBiQ47689.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47689-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTTQQNAPL KRTMKTRHLI MLSLGGVIGT GLFFNTGYII STTGAAGTLL
60 70 80 90 100
AYLIGALVVW LVMQCLGELS VAMPETGAFH VYAARYLGPA TGYTVAWLYW
110 120 130 140 150
LTWTVALGSS FTAAGFCMQY WFPQVPVWVW CVVFCAIIFG LNVISTRFFA
160 170 180 190 200
EGEFWFSLVK VVTIIAFIIL GGAAIFGFIP MQDGSPAPGL SNITAEGWFP
210 220 230 240 250
HGGLPILMTM VAVNFAFSGT ELIGIAAGET ENPRKVIPVA IRTTIARLII
260 270 280 290 300
FFIGTVFVLA ALIPMQQVGV EKSPFVLVFE KVGIPYAADI FNFVILTAIL
310 320 330 340 350
SAANSGLYAS GRMLWSLSNE RTLPACFARV TKNGVPLTAL SVSMLGGVLA
360 370 380 390 400
LFSSVVAPDT VFVALSAISG FAVVAVWLSI CASHFVFRRR HLQQGKALSE
410 420 430 440 450
LHYRAPWYPL VPVLGFVLCL VACVGLAFDP AQRIALWCGL PFVALCYGAY
460
FLTQPRNAKQ EPEHVAE
Length:467
Mass (Da):50,526
Last modified:August 29, 2001 - v2
Checksum:iE7ADB9A3B03C10F8
GO

Sequence cautioni

The sequence AAB08681 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70214 Genomic DNA. Translation: AAB08681.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73363.2.
AP009048 Genomic DNA. Translation: BAA77928.2.
PIRiD64751.
RefSeqiNP_414794.4. NC_000913.3.
WP_001393629.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73363; AAC73363; b0260.
BAA77928; BAA77928; BAA77928.
GeneIDi946284.
KEGGiecj:JW5027.
eco:b0260.
PATRICi32115639. VBIEscCol129921_0263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70214 Genomic DNA. Translation: AAB08681.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73363.2.
AP009048 Genomic DNA. Translation: BAA77928.2.
PIRiD64751.
RefSeqiNP_414794.4. NC_000913.3.
WP_001393629.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliQ47689.
SMRiQ47689. Positions 25-425.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259776. 11 interactions.
STRINGi511145.b0260.

Protein family/group databases

TCDBi2.A.3.1.10. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PaxDbiQ47689.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73363; AAC73363; b0260.
BAA77928; BAA77928; BAA77928.
GeneIDi946284.
KEGGiecj:JW5027.
eco:b0260.
PATRICi32115639. VBIEscCol129921_0263.

Organism-specific databases

EchoBASEiEB3126.
EcoGeneiEG13342. mmuP.

Phylogenomic databases

eggNOGiENOG4108IQI. Bacteria.
COG0833. LUCA.
HOGENOMiHOG000261850.
InParanoidiQ47689.
KOiK16235.
OMAiCASHYVF.
PhylomeDBiQ47689.

Enzyme and pathway databases

BioCyciEcoCyc:B0260-MONOMER.
ECOL316407:JW5027-MONOMER.
MetaCyc:B0260-MONOMER.

Miscellaneous databases

PROiQ47689.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMMUP_ECOLI
AccessioniPrimary (citable) accession number: Q47689
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 29, 2001
Last modified: September 7, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.