Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable ABC transporter periplasmic-binding protein SapA

Gene

sapA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Not part of a putrescine export system (PubMed:27803167). Very similar to a S.typhimurium protein implicated in antimicrobial peptide resistance, but the SapBCDF operon in E.coli is implicated in putrescine export (PubMed:27803167).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:SAPA-MONOMER

Protein family/group databases

TCDBi3.A.1.5.42 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ABC transporter periplasmic-binding protein SapACurated
Gene namesi
Name:sapA
Ordered Locus Names:b1294, JW1287
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG20254 sapA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

Pathology & Biotechi

Disruption phenotypei

No change in extracellular putrescine levels.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003180122 – 547Probable ABC transporter periplasmic-binding protein SapAAdd BLAST526

Proteomic databases

PaxDbiQ47622
PRIDEiQ47622

Interactioni

Protein-protein interaction databases

BioGridi4261257, 254 interactors
DIPiDIP-10822N
IntActiQ47622, 5 interactors
STRINGi316385.ECDH10B_1411

Structurei

3D structure databases

ProteinModelPortaliQ47622
SMRiQ47622
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108HIY Bacteria
COG4166 LUCA
HOGENOMiHOG000164955
InParanoidiQ47622
KOiK19226
OMAiTMFEDLS
PhylomeDBiQ47622

Family and domain databases

InterProiView protein in InterPro
IPR030678 Peptide/Ni-bd
IPR023765 SBP_5_CS
IPR000914 SBP_5_dom
PfamiView protein in Pfam
PF00496 SBP_bac_5, 1 hit
PIRSFiPIRSF002741 MppA, 1 hit
PROSITEiView protein in PROSITE
PS01040 SBP_BACTERIAL_5, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q47622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQVLSSLLV IAGLVSGQAI AAPESPPHAD IRDSGFVYCV SGQVNTFNPS
60 70 80 90 100
KASSGLIVDT LAAQFYDRLL DVDPYTYRLM PELAESWEVL DNGATYRFHL
110 120 130 140 150
RRDVPFQKTD WFTPTRKMNA DDVVFTFQRI FDRNNPWHNV NGSNFPYFDS
160 170 180 190 200
LQFADNVKSV RKLDNHTVEF RLAQPDASFL WHLATHYASV MSAEYARKLE
210 220 230 240 250
KEDRQEQLDR QPVGTGPYQL SEYRAGQFIR LQRHDDFWRG KPLMPQVVVD
260 270 280 290 300
LGSGGTGRLS KLLTGECDVL AWPAASQLSI LRDDPRLRLT LRPGMNVAYL
310 320 330 340 350
AFNTAKPPLN NPAVRHALAL AINNQRLMQS IYYGTAETAA SILPRASWAY
360 370 380 390 400
DNEAKITEYN PAKSREQLKS LGLENLTLKL WVPTRSQAWN PSPLKTAELI
410 420 430 440 450
QADMAQVGVK VVIVPVEGRF QEARLMDMSH DLTLSGWATD SNDPDSFFRP
460 470 480 490 500
LLSCAAIHSQ TNLAHWCDPK FDSVLRKALS SQQLAARIEA YDEAQSILAQ
510 520 530 540
ELPILPLASS LRLQAYRYDI KGLVLSPFGN ASFAGVYREK QDEVKKP
Length:547
Mass (Da):61,565
Last modified:November 1, 1996 - v1
Checksum:iEB552BB3B8E102BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34 – 35SG → RV (PubMed:9097039).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97282 Genomic DNA Translation: CAA65937.1
U00096 Genomic DNA Translation: AAC74376.1
AP009048 Genomic DNA Translation: BAA14855.2
PIRiA64878
RefSeqiNP_415810.1, NC_000913.3
WP_001250216.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74376; AAC74376; b1294
BAA14855; BAA14855; BAA14855
GeneIDi945873
KEGGiecj:JW1287
eco:b1294
PATRICifig|1411691.4.peg.985

Similar proteinsi

Entry informationi

Entry nameiSAPA_ECOLI
AccessioniPrimary (citable) accession number: Q47622
Secondary accession number(s): P77358
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health