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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (Reut_A2819)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00131

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotation
Ordered Locus Names:Reut_A0556
OrganismiCupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000002697 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000187661 – 302Phosphoribosylaminoimidazole-succinocarboxamide synthaseAdd BLAST302

Interactioni

Protein-protein interaction databases

STRINGi264198.Reut_A0556

Structurei

3D structure databases

ProteinModelPortaliQ475J5
SMRiQ475J5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8V Bacteria
COG0152 LUCA
HOGENOMiHOG000230360
KOiK01923
OMAiEMVIRGY
OrthoDBiPOG091H01GT

Family and domain databases

HAMAPiMF_00137 SAICAR_synth, 1 hit
InterProiView protein in InterPro
IPR028923 SAICAR_synt/ADE2_N
IPR001636 SAICAR_synth
IPR018236 SAICAR_synthetase_CS
PfamiView protein in Pfam
PF01259 SAICAR_synt, 1 hit
TIGRFAMsiTIGR00081 purC, 1 hit
PROSITEiView protein in PROSITE
PS01057 SAICAR_SYNTHETASE_1, 1 hit
PS01058 SAICAR_SYNTHETASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q475J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNALYQSSI SSLPLLGHGK VRDNYAVGED KLLIVTTDRL SAFDVIMGEP
60 70 80 90 100
IPDKGRVLNQ MANFWFRKLA HIVPNHETGV AAETVVAPAE VEQVKGRAVV
110 120 130 140 150
VKRLKPILVE AVVRGYLAGS GWKDYQATGK VCGIELPAGL QNAQKLPEPI
160 170 180 190 200
FTPAAKAEMG EHDENISFGE VEERIGIALA RQMRDISIRL YKEAAEFAAT
210 220 230 240 250
RGIIIADTKF EFGLDENGTL TLMDEVLTAD SSRFWPADSY QVGTNPPSFD
260 270 280 290 300
KQFVRDWLEA VRIDGKPWPK TAPAPKLPDD VIEKTAAKYR EALTRLTGEE

LQ
Length:302
Mass (Da):33,304
Last modified:September 13, 2005 - v1
Checksum:i983E1FEAB560F35F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000090 Genomic DNA Translation: AAZ59938.1
RefSeqiWP_011296745.1, NC_007347.1

Genome annotation databases

EnsemblBacteriaiAAZ59938; AAZ59938; Reut_A0556
KEGGireu:Reut_A0556

Similar proteinsi

Entry informationi

Entry nameiPUR7_CUPNJ
AccessioniPrimary (citable) accession number: Q475J5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: February 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome