Reviewed, UniProtKB/Swiss-Prot Q474J5 (KYNB_RALEJ)

Names and origin

Protein names

Recommended name:
    Kynurenine formamidase
      Short name=KFA
    EC=3.5.1.9
Alternative name(s):
    N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	Reut_A0809

Organism

Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) [Complete proteome] [HAMAP]

Taxonomic identifier

264198 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 219	219	Kynurenine formamidase		PRO_0000362134

Sequences

	Sequence		Length	Mass (Da)
	Q474J5-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 67A6213813331F28	FASTA	219	23,616
	10 20 30 40 50 60 MTNRPATPAD SRKLWDISPP LSPATPVWPG DTPFQQETAW QMDEHCPVNV GRITLSPHTG 70 80 90 100 110 120 AHADAPLHYA ADGAPIGEVG LEPYLGRCRV IHCVGATPVV APHHVEHALN DLPTRVLLRT 130 140 150 160 170 180 YKRAPLDQWD TGFCAVAPET IALLAAHGVQ LIGIDTPSLD PQESKTMDAH KAVRRHGLAI 190 200 210 LEGLVLDAVA EGDYELIALP LRFTGLDASP VRAVLRSLD

References

[1]

"Complete sequence of chromosome 1 of Ralstonia eutropha JMP134." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000090 Genomic DNA. Translation: AAZ60188.1.
RefSeq	YP_295032.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3610803.
GenomeReviews	Gene locus Reut_A0809 in contig CP000090_GR.
KEGG	reu:Reut_A0809.
NMPDR	fig|264198.3.peg.1322.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q474J5.
OMA	WPGDTPF.
Enzyme and pathway databases
BioCyc	REUT264198:REUT_A0809-MON.
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_RALEJ

Accession

Primary (citable) accession number: Q474J5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	September 13, 2005
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)