Q474J5 (KYNB_CUPPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine formamidase
Short name=KFA
EC=3.5.1.9

Alternative name(s):
N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	Reut_A0809

Organism

Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes eutrophus) (Ralstonia eutropha) [Complete proteome] [HAMAP]

Taxonomic identifier

264198 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB formamidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 219	219	Kynurenine formamidase		PRO_0000362134

Sequences

	Sequence		Length	Mass (Da)
	Q474J5 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 67A6213813331F28	FASTA	219	23,616
	10 20 30 40 50 60 MTNRPATPAD SRKLWDISPP LSPATPVWPG DTPFQQETAW QMDEHCPVNV GRITLSPHTG 70 80 90 100 110 120 AHADAPLHYA ADGAPIGEVG LEPYLGRCRV IHCVGATPVV APHHVEHALN DLPTRVLLRT 130 140 150 160 170 180 YKRAPLDQWD TGFCAVAPET IALLAAHGVQ LIGIDTPSLD PQESKTMDAH KAVRRHGLAI 190 200 210 LEGLVLDAVA EGDYELIALP LRFTGLDASP VRAVLRSLD

References

[1]

"Complete sequence of chromosome 1 of Ralstonia eutropha JMP134." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JMP134 / LMG 1197.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000090 Genomic DNA. Translation: AAZ60188.1.
RefSeq	YP_295032.1. NC_007347.1.
3D structure databases
ProteinModelPortal	Q474J5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q474J5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3610803.
GenomeReviews	Gene locus Reut_A0809 in contig CP000090_GR.
KEGG	reu:Reut_A0809.
NMPDR	fig|264198.3.peg.1322.
PATRIC	20227093. VBIRalEut24049_1420.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG686791.
OMA	HTSKWPL.
ProtClustDB	CLSK769116.
Enzyme and pathway databases
BioCyc	REUT264198:REUT_A0809-MONOMER.
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
KO	K07130.
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. Trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_CUPPJ

Accession

Primary (citable) accession number: Q474J5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program