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Protein

Probable sensor protein PcoS

Gene

pcoS

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable member of a two-component regulatory system PcoS/PcoR. May activate PcoR by phosphorylation.

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
Biological processTwo-component regulatory system
LigandATP-binding, Copper, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable sensor protein PcoS (EC:2.7.13.3)
Gene namesi
Name:pcoS
Encoded oniPlasmid pRJ10040 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 171PeriplasmicSequence analysisAdd BLAST140
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Topological domaini193 – 466CytoplasmicSequence analysisAdd BLAST274

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000747381 – 466Probable sensor protein PcoSAdd BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei257Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ47457.
SMRiQ47457.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini193 – 246HAMPPROSITE-ProRule annotationAdd BLAST54
Domaini254 – 466Histidine kinasePROSITE-ProRule annotationAdd BLAST213

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105GR3. Bacteria.
COG0642. LUCA.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
cd00075. HATPase_c. 1 hit.
cd00082. HisKA. 1 hit.
Gene3Di3.30.565.10. 1 hit.
InterProiView protein in InterPro
IPR006290. CztS_silS_copS.
IPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR036890. HATPase_C_sf.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR036097. HisK_dim/P_sf.
IPR004358. Sig_transdc_His_kin-like_C.
PfamiView protein in Pfam
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiView protein in SMART
SM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01386. cztS_silS_copS. 1 hit.
PROSITEiView protein in PROSITE
PS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFKISLTTR LSLIFSAVML TVWWLSSFIL ISTLNDYFDN QDRDFLTGKL
60 70 80 90 100
QLTEEFLKTE TFRNKTDIKS LSEKINDAMV GHNGLFISIK NMENEKIVEL
110 120 130 140 150
YAKNSVVPAV LLNKSGDILD YMIQTEENNT VYRSISRRVA VTPEQGKSKH
160 170 180 190 200
VIITVATDTG YHTLLMDKLS TWLFWFNIGL VFISVFLGWL TTRIGLKPLR
210 220 230 240 250
EMTSLASSMT VHSLDQRLNP DLAPPEISET MQEFNNMFDR LEGAFRKLSD
260 270 280 290 300
FSSDIAHELR TPVSNLMMQT QFALAKERDV SHYREILFAN LEELKRLSRM
310 320 330 340 350
TSDMLFLARS EHGLLRLDKH DVDLAAELNE LRELFEPLAD ETGKTITVEG
360 370 380 390 400
EGVVAGDSDM LRRAFSNLLS NAIKYSPDNT CTAIHLERDS DCVNVMITNT
410 420 430 440 450
MSGQVPANLE RLFDRFYRAD SSRFYNTEGA GLGLSITRSI IHAHGGELSA
460
EQQGREIVFK VRLLMD
Length:466
Mass (Da):53,071
Last modified:November 1, 1996 - v1
Checksum:iE352DA64FADA5A8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83541 Genomic DNA. Translation: CAA58530.1.
PIRiS70165. S52258.

Similar proteinsi

Entry informationi

Entry nameiPCOS_ECOLX
AccessioniPrimary (citable) accession number: Q47457
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid