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Protein

Probable sensor protein PcoS

Gene

pcoS

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable member of a two-component regulatory system PcoS/PcoR. May activate PcoR by phosphorylation.

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Copper, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable sensor protein PcoS (EC:2.7.13.3)
Gene namesi
Name:pcoS
Encoded oniPlasmid pRJ10040 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 171PeriplasmicSequence analysisAdd BLAST140
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Topological domaini193 – 466CytoplasmicSequence analysisAdd BLAST274

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000747381 – 466Probable sensor protein PcoSAdd BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei257Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi481805.EcolC_3411.

Structurei

3D structure databases

ProteinModelPortaliQ47457.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini193 – 246HAMPPROSITE-ProRule annotationAdd BLAST54
Domaini254 – 466Histidine kinasePROSITE-ProRule annotationAdd BLAST213

Sequence similaritiesi

Contains 1 HAMP domain.PROSITE-ProRule annotation
Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105GR3. Bacteria.
COG0642. LUCA.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR006290. CztS_silS_copS.
IPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01386. cztS_silS_copS. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFKISLTTR LSLIFSAVML TVWWLSSFIL ISTLNDYFDN QDRDFLTGKL
60 70 80 90 100
QLTEEFLKTE TFRNKTDIKS LSEKINDAMV GHNGLFISIK NMENEKIVEL
110 120 130 140 150
YAKNSVVPAV LLNKSGDILD YMIQTEENNT VYRSISRRVA VTPEQGKSKH
160 170 180 190 200
VIITVATDTG YHTLLMDKLS TWLFWFNIGL VFISVFLGWL TTRIGLKPLR
210 220 230 240 250
EMTSLASSMT VHSLDQRLNP DLAPPEISET MQEFNNMFDR LEGAFRKLSD
260 270 280 290 300
FSSDIAHELR TPVSNLMMQT QFALAKERDV SHYREILFAN LEELKRLSRM
310 320 330 340 350
TSDMLFLARS EHGLLRLDKH DVDLAAELNE LRELFEPLAD ETGKTITVEG
360 370 380 390 400
EGVVAGDSDM LRRAFSNLLS NAIKYSPDNT CTAIHLERDS DCVNVMITNT
410 420 430 440 450
MSGQVPANLE RLFDRFYRAD SSRFYNTEGA GLGLSITRSI IHAHGGELSA
460
EQQGREIVFK VRLLMD
Length:466
Mass (Da):53,071
Last modified:November 1, 1996 - v1
Checksum:iE352DA64FADA5A8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83541 Genomic DNA. Translation: CAA58530.1.
PIRiS70165. S52258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83541 Genomic DNA. Translation: CAA58530.1.
PIRiS70165. S52258.

3D structure databases

ProteinModelPortaliQ47457.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi481805.EcolC_3411.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105GR3. Bacteria.
COG0642. LUCA.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR006290. CztS_silS_copS.
IPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01386. cztS_silS_copS. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCOS_ECOLX
AccessioniPrimary (citable) accession number: Q47457
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.