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Protein

Copper resistance protein C

Gene

pcoC

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Required for the copper-inducible expression of copper resistance.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi24 – 241CopperSequence analysis
Metal bindingi115 – 1151CopperSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Copper resistance protein C
Gene namesi
Name:pcoC
Encoded oniPlasmid pRJ10040 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 126103Copper resistance protein CPRO_0000006026Add
BLAST

Interactioni

Protein-protein interaction databases

DIPiDIP-16994N.
STRINGi481805.EcolC_3414.

Structurei

Secondary structure

1
126
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 326Combined sources
Beta strandi37 – 393Combined sources
Beta strandi44 – 507Combined sources
Helixi54 – 563Combined sources
Beta strandi58 – 669Combined sources
Beta strandi75 – 773Combined sources
Beta strandi79 – 835Combined sources
Beta strandi89 – 968Combined sources
Beta strandi100 – 10910Combined sources
Beta strandi117 – 1259Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IX2X-ray1.55A/B23-126[»]
1LYQX-ray1.50A/B23-126[»]
ProteinModelPortaliQ47454.
SMRiQ47454. Positions 23-126.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ47454.

Family & Domainsi

Sequence similaritiesi

Belongs to the CopC family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105JDN. Bacteria.
COG2372. LUCA.
OMAiGMADHAP.

Family and domain databases

Gene3Di2.60.40.1220. 1 hit.
InterProiIPR007348. CopC_dom.
IPR014755. Cu-Rt/internalin_Ig-like.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF04234. CopC. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q47454-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILNKAILT GGLVMGVAFS AMAHPELKSS VPQADSAVAA PEKIQLNFSE
60 70 80 90 100
NLTVKFSGAK LTMTGMKGMS SHSPMPVAAK VAPGADPKSM VIIPREPLPA
110 120
GTYRVDWRAV SSDTHPITGN YTFTVK
Length:126
Mass (Da):13,256
Last modified:November 1, 1996 - v1
Checksum:iA8C74B37F3489835
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83541 Genomic DNA. Translation: CAA58527.1.
PIRiS70161. S52255.
RefSeqiWP_000025662.1. NZ_LRXV01000105.1.

Genome annotation databases

GeneIDi5550743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83541 Genomic DNA. Translation: CAA58527.1.
PIRiS70161. S52255.
RefSeqiWP_000025662.1. NZ_LRXV01000105.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IX2X-ray1.55A/B23-126[»]
1LYQX-ray1.50A/B23-126[»]
ProteinModelPortaliQ47454.
SMRiQ47454. Positions 23-126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-16994N.
STRINGi481805.EcolC_3414.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5550743.

Phylogenomic databases

eggNOGiENOG4105JDN. Bacteria.
COG2372. LUCA.
OMAiGMADHAP.

Miscellaneous databases

EvolutionaryTraceiQ47454.

Family and domain databases

Gene3Di2.60.40.1220. 1 hit.
InterProiIPR007348. CopC_dom.
IPR014755. Cu-Rt/internalin_Ig-like.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF04234. CopC. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular genetics and transport analysis of the copper-resistance determinant (pco) from Escherichia coli plasmid pRJ1004."
    Brown N.L., Barrett S.R., Camakaris J., Lee B.T.O., Rouch D.A.
    Mol. Microbiol. 17:1153-1166(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPCOC_ECOLX
AccessioniPrimary (citable) accession number: Q47454
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.