Reviewed,
UniProtKB/Swiss-Prot Q47329 (UDG5_ECOLX)
Last modified
November 25, 2008.
Version 51.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: UDP-glucose 6-dehydrogenase Short name=UDP-Glc dehydrogenase Short name=UDP-GlcDH Short name=UDPGDH EC=1.1.1.22 | ||
| Gene names |
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| Organism | Escherichia coli | ||
| Taxonomic identifier | 562 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 392 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the formation of UDP-glucuronic acid which is required for K5 capsule synthesis. |
| Catalytic activity | UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH. |
| Pathway | |
| Post-translational modification | Phosphorylated on a tyrosine residue. It results in a significant increase of the dehydrogenase activity By similarity. |
| Sequence similarities | Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Capsule biogenesis/degradation |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | NAD binding Inferred from electronic annotation. Source: InterPro UDP-glucose 6-dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Region 2 of the Escherichia coli K5 capsule gene cluster encoding proteins for the biosynthesis of the K5 polysaccharide." Petit C., Rigg G., Pazzani C., Smith A., Sieberth V., Stevens M., Boulnois G., Jann K., Roberts I.S. Mol. Microbiol. 17:611-620(1995) [PubMed: 8801416] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K5. |
Cross-references
Sequence databases | |
|---|---|
| X77617 Genomic DNA. Translation: CAA54708.1. | |
| PIR | S70197. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1DLI based on UniProtKB Q07172. |
| ModBase | Search... |
Family and domain databases | |
| InterPro | IPR016040. NAD(P)-bd. IPR017476. Nucleotide_sugar_DH. IPR014027. UDP-Glc/GDP-Man_DHase_C. IPR014026. UDP-Glc/GDP-Man_DHase_dimer. IPR014028. UDP-Glc/GDP-Man_DHase_dimer-bd. IPR001732. UDP-Glc/GDP-Man_DHase_N. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:3.40.50.1870. UDP-Glc/GDP-Man_DH_C. 1 hit. |
| PANTHER | PTHR11374. UDPG_MGDP_DH_Creg. 1 hit. |
| Pfam | PF00984. UDPG_MGDP_dh. 1 hit. PF03720. UDPG_MGDP_dh_C. 1 hit. PF03721. UDPG_MGDP_dh_N. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | UDG5_ECOLX | ||||||||
| Accession | Primary (citable) accession number: Q47329 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


