Reviewed, UniProtKB/Swiss-Prot Q472C7 (G6PI1_RALEJ)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase 1
      Short name=GPI 1
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase 1
      Short name=PGI 1
    Phosphohexose isomerase 1
      Short name=PHI 1

Gene names

Name:	pgi1
Ordered Locus Names:	Reut_A1386

Organism

Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) [Complete proteome] [HAMAP]

Taxonomic identifier

264198 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

Protein attributes

Sequence length	545 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 545	545	Glucose-6-phosphate isomerase 1 HAMAP MF_00473		PRO_0000230929
Sites
	Active site	356	1	Proton donor By similarity
	Active site	387	1	By similarity
	Active site	508	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q472C7-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: E29376EAA5B69B83	FASTA	545	59,755
	10 20 30 40 50 60 MPTNLHAWNA LQQHHDAIRD HQMADWFAEN GADRVRQFSL EAAGLYLDYS KNRITPQTMQ 70 80 90 100 110 120 LLLQLADEAG VPARRDAMFA GEHINATEDR AALHVALRAT AGAGFKVDGV PVVPAIQNVL 130 140 150 160 170 180 VRMRAFSEAV RSGAWTGTTG ERITDVVNIG IGGSDLGPKM VCRALSHLAH DDGHSGPRMH 190 200 210 220 230 240 FVSNVDGTEL AEALERLDPR RTLMIVCSKT FTTLETMANA HSARQWYLDN GVAEDQLARH 250 260 270 280 290 300 FVAVSTNVDA VRAFGIDPAN MFEFWDWIGG RFSLWSSVGL STALAVGFNA FADLLAGGRA 310 320 330 340 350 360 MDEHFRTAPL ERNMPVVLGM LGIWYRNFFN LPTSCMAPYS TSLELFPAFL QQLEMESNGK 370 380 390 400 410 420 TVQLNGRRVR THTSPVVWGT AGTNGQHAYF QMIHQGSQIV PVDFVAPLVP PRELPGHHAK 430 440 450 460 470 480 LLANCFAQAE ALMRGRSAEE LRAAGMTDEL RIAHMVFEGN RPSNTLLMED LTPHVLGALI 490 500 510 520 530 540 ALYEHRTFVQ GVVWNINSFD QWGVELGKIL ARPIESELNG AQAGSHDAST AALIARARGV LARNG

References

[1]

"Complete sequence of chromosome 1 of Ralstonia eutropha JMP134." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000090 Genomic DNA. Translation: AAZ60756.1.
RefSeq	YP_295600.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3611179.
GenomeReviews	Gene locus Reut_A1386 in contig CP000090_GR.
KEGG	reu:Reut_A1386.
NMPDR	fig|264198.3.peg.2140.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q472C7.
OMA	GPKIVSQ.
Enzyme and pathway databases
BioCyc	REUT264198:REUT_A1386-MON.
Family and domain databases
HAMAP	MF_00473. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI1_RALEJ

Accession

Primary (citable) accession number: Q472C7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	September 13, 2005
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)