Reviewed, UniProtKB/Swiss-Prot Q471B8 (G6PI2_RALEJ)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase 2
      Short name=GPI 2
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase 2
      Short name=PGI 2
    Phosphohexose isomerase 2
      Short name=PHI 2

Gene names

Name:	pgi2
Ordered Locus Names:	Reut_A1649

Organism

Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) [Complete proteome] [HAMAP]

Taxonomic identifier

264198 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

Protein attributes

Sequence length	542 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 542	542	Glucose-6-phosphate isomerase 2 HAMAP MF_00473		PRO_0000230930
Sites
	Active site	353	1	Proton donor By similarity
	Active site	384	1	By similarity
	Active site	505	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q471B8-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 66588D86F2F0CC0F	FASTA	542	59,420
	10 20 30 40 50 60 MSTSLSAWQS LREHAAKIRH THMRDWFTGP QGQARSVRLT VEACGLTLDY AKNRVTEDTL 70 80 90 100 110 120 SLLFALARQA RVCERRDAMF AGEPVNTTER RAALHMALRA HPGDGYRALG VPVEADVSAV 130 140 150 160 170 180 LAQMERFARD VRSGSWTGFD GRAITDVVNI GIGGSDLGPR MVCRALEQDT EPGPRLHFVA 190 200 210 220 230 240 NVDGYDLART LARLDAATTL VIVCSKTFTT LETMANARTA RDWFLRHGVT HSDLARHFVA 250 260 270 280 290 300 VSTNRDAVAA FGIDPVNMFP FWDWVGGRFS LWSAVGLSIA VAIGFDRFRQ LLDGARAMDR 310 320 330 340 350 360 HFAGAPPEQN LPMILGLLDV WYRSFLGTAS RCVAPYCEPL DLLPAFLQQL EMESNGKSVQ 370 380 390 400 410 420 HDGAALEAGS AAVVWGTTGT NGQHAYFQMV HQGSQLVPVD FIACLQPHSD LPGHHTKLLA 430 440 450 460 470 480 NCFAQGEALL RGRTADEVRA EGKADEALVP HLVFEGNRPS NTLLLQRLDA FHLGALLAMS 490 500 510 520 530 540 EHRTFVQGAL WNINPFDQWG VELGKMLARP IERELEGAPP QPHDASTAAL IRRAAQFCAS TD

References

[1]

"Complete sequence of chromosome 1 of Ralstonia eutropha JMP134." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000090 Genomic DNA. Translation: AAZ61015.1.
RefSeq	YP_295859.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3610248.
GenomeReviews	Gene locus Reut_A1649 in contig CP000090_GR.
KEGG	reu:Reut_A1649.
NMPDR	fig|264198.3.peg.2091.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q471B8.
OMA	FDGRAIT.
Enzyme and pathway databases
BioCyc	REUT264198:REUT_A1649-MON.
Family and domain databases
HAMAP	MF_00473. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI2_RALEJ

Accession

Primary (citable) accession number: Q471B8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	September 13, 2005
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)