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Protein

Beta-galactosidase

Gene

ebgR

Organism
Escherichia coli
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotationSAAS annotation, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidaseUniRule annotation (EC:3.2.1.23UniRule annotation)
Alternative name(s):
LactaseUniRule annotation
Gene namesi
Name:ebgRImported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi469008.ECD_02945.

Structurei

3D structure databases

ProteinModelPortaliQ47170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini660 – 937278Bgal_small_NInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CNT. Bacteria.
COG3250. LUCA.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. GH-type_carb-bd.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR006103. Glyco_hydro_2_cat.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR032312. LacZ_4.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF16353. DUF4981. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47170-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADWGHITVP AMWQMEGHGK LQYTDEGFPF PIDVPFVPSD NPTGAYQRIF
60 70 80 90 100
TLSDGWQGKQ TLIKFDGVET YFEVYVNGQY VGFSKGSRLT AEFDISAMVK
110 120 130 140 150
TGDNLLCVRV MQWADSTYVE DQDMWWSAGI FRDVYLVGKH LTHINDFTVR
160 170 180 190 200
TDFDEAYCDA TLSCEVVLEN LAASPVVTTL EYTLFDGERV VHSSAIDHLA
210 220 230 240 250
IEKLTSATFA FTVEQPQQWS AESPYLYHLV MTLKDANGNV LEVVPQRVGF
260 270 280 290 300
RDIKVRDGLF WINNRYVMLH GVNRHDNDHR KGRAVGMDRV EKDLQLMKQH
310 320 330 340 350
NINSVRTAHY PNDPRFYELC DIYGLFVMAE TDVESHGFAN VGDISRITDD
360 370 380 390 400
PQWEKVYVER IVRHIHAQKN HPSIIIWSLG NESGYGCNIR AMYHAAKRLD
410 420 430 440 450
DTRLVHYEED RDAEVVDIIS TMYTRVPLMN EFGEYPHPKP RIICEYAHAM
460 470 480 490 500
GNGPGGLTEY QNVFYKHDCI QGHYVWEWCD HGIQAQDDHG NVWYKFGGDY
510 520 530 540 550
GDYPNNYNFC LDGLIYSDQT PGPGLKEYKQ VIAPVKIHAR DLTRGELKVE
560 570 580 590 600
NKLWFTTLDD YTLHAEVRAE GESLATQQIK LPDVAPNSEA PLQITCRSWT
610 620 630 640 650
PAKRSLNITV TKDSRTRYSE AGHPIATYQF PLKENTAQPV PFAPNKCASV
660 670 680 690 700
TLEDDRLSCT VRGYNFAITF SKMSGKPTSW QVNGESLLTR EPKINFFKPM
710 720 730 740 750
MIDNHKQEYE GLWQPNHLQI MQEHLRDFAV EQSDGEVLII SRTVIAPPVF
760 770 780 790 800
DFGMRCTYIW RIAADGQVNV ALSGERYGDY PHIIPCIGFT MGINGEYDQV
810 820 830 840 850
AYYGRGPGEN YADSQQANII DIWRQAVDAM FENYPFPQNN GNRQHVRWTA
860 870 880 890 900
LTNRHGNGLL VVPQRPINFS AWHYTQENIH AAQHCNELQR SDDITLGTSI
910 920 930 940 950
TSCLASAPTP GAARCWTPGA SGSVTSATAL RCCRFLAEKL PRKAWRRMSS
960
AQGSFPRICT RRIS
Length:964
Mass (Da):109,741
Last modified:November 1, 1996 - v1
Checksum:i9D668C9AE652E47F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03228 Genomic DNA. Translation: CAA26978.1.
PIRiA65096. GBECE.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03228 Genomic DNA. Translation: CAA26978.1.
PIRiA65096. GBECE.

3D structure databases

ProteinModelPortaliQ47170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi469008.ECD_02945.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CNT. Bacteria.
COG3250. LUCA.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. GH-type_carb-bd.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR006103. Glyco_hydro_2_cat.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR032312. LacZ_4.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF16353. DUF4981. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence of the ebgR gene of Escherichia coli: evidence that the EBG and LAC operons are descended from a common ancestor."
    Stokes H.W., Hall B.G.
    Mol. Biol. Evol. 2:478-483(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ47170_ECOLX
AccessioniPrimary (citable) accession number: Q47170
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.