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Protein

Probable endopeptidase YafL

Gene

yafL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei147NucleophileBy similarity1
Active sitei202Proton acceptorBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyciEcoCyc:G6111-MONOMER.
ECOL316407:JW0217-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endopeptidase YafL (EC:3.4.-.-)
Alternative name(s):
Uncharacterized lipoprotein YafL
Gene namesi
Name:yafL
Ordered Locus Names:b0227, JW0217
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13149. yafL.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001976718 – 249Probable endopeptidase YafLAdd BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi18N-palmitoyl cysteineSequence analysis1
Lipidationi18S-diacylglycerol cysteineSequence analysis1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ47151.
PRIDEiQ47151.

Interactioni

Protein-protein interaction databases

BioGridi4259761. 264 interactors.
IntActiQ47151. 6 interactors.
STRINGi511145.b0227.

Structurei

3D structure databases

ProteinModelPortaliQ47151.
SMRiQ47151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C40 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108YS0. Bacteria.
COG0791. LUCA.
HOGENOMiHOG000229978.
InParanoidiQ47151.
OMAiRYGPGYT.
PhylomeDBiQ47151.

Family and domain databases

Gene3Di3.90.1720.10. 1 hit.
InterProiIPR000064. NLP_P60_dom.
[Graphical view]
PfamiPF00877. NLPC_P60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q47151-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPSIPSFV LSGLLLICLP FSSFASATTS HISFSYAARQ RMQNRARLLK
60 70 80 90 100
QYQTHLKKQA SYIVEGNAES KRALRQHNRE QIKQHPEWFP APLKASDRRW
110 120 130 140 150
QALAENNHFL SSDHLHNITE VAIHRLEQQL GKPYVWGGTR PDKGFDCSGL
160 170 180 190 200
VFYAYNKILE AKLPRTANEM YHYRRATIVA NNDLRRGDLL FFHIHSREIA
210 220 230 240
DHMGVYLGDG QFIESPRTGE TIRISRLAEP FWQDHFLGAR RILTEETIL
Length:249
Mass (Da):28,785
Last modified:November 1, 1997 - v1
Checksum:i3C4F4618212C3466
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38582 Genomic DNA. Translation: BAA07589.1.
U70214 Genomic DNA. Translation: AAB08647.1.
U00096 Genomic DNA. Translation: AAC73331.1.
AP009048 Genomic DNA. Translation: BAA77897.2.
PIRiD64747.
RefSeqiNP_414762.1. NC_000913.3.
WP_000056849.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73331; AAC73331; b0227.
BAA77897; BAA77897; BAA77897.
GeneIDi944899.
KEGGiecj:JW0217.
eco:b0227.
PATRICi32115569. VBIEscCol129921_0229.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38582 Genomic DNA. Translation: BAA07589.1.
U70214 Genomic DNA. Translation: AAB08647.1.
U00096 Genomic DNA. Translation: AAC73331.1.
AP009048 Genomic DNA. Translation: BAA77897.2.
PIRiD64747.
RefSeqiNP_414762.1. NC_000913.3.
WP_000056849.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliQ47151.
SMRiQ47151.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259761. 264 interactors.
IntActiQ47151. 6 interactors.
STRINGi511145.b0227.

Proteomic databases

PaxDbiQ47151.
PRIDEiQ47151.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73331; AAC73331; b0227.
BAA77897; BAA77897; BAA77897.
GeneIDi944899.
KEGGiecj:JW0217.
eco:b0227.
PATRICi32115569. VBIEscCol129921_0229.

Organism-specific databases

EchoBASEiEB2943.
EcoGeneiEG13149. yafL.

Phylogenomic databases

eggNOGiENOG4108YS0. Bacteria.
COG0791. LUCA.
HOGENOMiHOG000229978.
InParanoidiQ47151.
OMAiRYGPGYT.
PhylomeDBiQ47151.

Enzyme and pathway databases

BioCyciEcoCyc:G6111-MONOMER.
ECOL316407:JW0217-MONOMER.

Miscellaneous databases

PROiQ47151.

Family and domain databases

Gene3Di3.90.1720.10. 1 hit.
InterProiIPR000064. NLP_P60_dom.
[Graphical view]
PfamiPF00877. NLPC_P60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYAFL_ECOLI
AccessioniPrimary (citable) accession number: Q47151
Secondary accession number(s): Q9R2E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.