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Protein

Probable 3-phenylpropionic acid transporter

Gene

hcaT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable permease involved in the uptake of 3-phenylpropionic acid.

GO - Molecular functioni

Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:HCAT-MONOMER

Protein family/group databases

TCDBi2.A.1.27.1 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3-phenylpropionic acid transporter
Gene namesi
Name:hcaT
Synonyms:yfhS
Ordered Locus Names:b2536, JW2520
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13454 hcaT

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicBy similarity4
Transmembranei5 – 31Helical; Name=1By similarityAdd BLAST27
Topological domaini32 – 37PeriplasmicBy similarity6
Transmembranei38 – 66Helical; Name=2By similarityAdd BLAST29
Topological domaini67 – 70CytoplasmicBy similarity4
Transmembranei71 – 96Helical; Name=3By similarityAdd BLAST26
Topological domaini97 – 100PeriplasmicBy similarity4
Transmembranei101 – 118Helical; Name=4By similarityAdd BLAST18
Topological domaini119 – 129CytoplasmicBy similarityAdd BLAST11
Transmembranei130 – 152Helical; Name=5By similarityAdd BLAST23
Topological domaini153 – 155PeriplasmicBy similarity3
Transmembranei156 – 175Helical; Name=6By similarityAdd BLAST20
Topological domaini176 – 207CytoplasmicBy similarityAdd BLAST32
Transmembranei208 – 227Helical; Name=7By similarityAdd BLAST20
Topological domaini228 – 231PeriplasmicBy similarity4
Transmembranei232 – 256Helical; Name=8By similarityAdd BLAST25
Topological domaini257 – 266CytoplasmicBy similarity10
Transmembranei267 – 286Helical; Name=9By similarityAdd BLAST20
Topological domaini287 – 289PeriplasmicBy similarity3
Transmembranei290 – 312Helical; Name=10By similarityAdd BLAST23
Topological domaini313 – 323CytoplasmicBy similarityAdd BLAST11
Transmembranei324 – 351Helical; Name=11By similarityAdd BLAST28
Topological domaini352 – 354PeriplasmicBy similarity3
Transmembranei355 – 375Helical; Name=12By similarityAdd BLAST21
Topological domaini376 – 379CytoplasmicBy similarity4

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001961891 – 379Probable 3-phenylpropionic acid transporterAdd BLAST379

Proteomic databases

PaxDbiQ47142
PRIDEiQ47142

Interactioni

Protein-protein interaction databases

BioGridi4261387, 11 interactors
STRINGi316385.ECDH10B_2703

Structurei

3D structure databases

ProteinModelPortaliQ47142
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D8G Bacteria
ENOG410XQVS LUCA
HOGENOMiHOG000272903
InParanoidiQ47142
KOiK05820
OMAiHGPYYTF
PhylomeDBiQ47142

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR026032 HcaT
IPR024989 MFS_assoc_dom
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF12832 MFS_1_like, 1 hit
PIRSFiPIRSF004925 HcaT, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00902 2A0127, 1 hit

Sequencei

Sequence statusi: Complete.

Q47142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLQSTRWLA LGYFTYFFSY GIFLPFWSVW LKGIGLTPET IGLLLGAGLV
60 70 80 90 100
ARFLGSLLIA PRVSDPSRLI SALRVLALLT LLFAVAFWAG AHVAWLMLVM
110 120 130 140 150
IGFNLFFSPL VPLTDALANT WQKQFPLDYG KVRLWGSVAF VIGSALTGKL
160 170 180 190 200
VTMFDYRVIL ALLTLGVASM LLGFLIRPTI QPQGASRQQE STGWSAWLAL
210 220 230 240 250
VRQNWRFLAC VCLLQGAHAA YYGFSAIYWQ AAGYSASAVG YLWSLGVVAE
260 270 280 290 300
VIIFALSNKL FRRCSARDML LISAICGVVR WGIMGATTAL PWLIVVQILH
310 320 330 340 350
CGTFTVCHLA AMRYIAARQG SEVIRLQAVY SAVAMGGSIA IMTVFAGFLY
360 370
QYLGHGVFWV MALVALPAMF LRPKVVPSC
Length:379
Mass (Da):41,593
Last modified:November 1, 1997 - v2
Checksum:i76429AD807623482
GO

Sequence cautioni

The sequence CAA86021 differs from that shown. Reason: Frameshift at position 208.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191S → N in CAA71954 (PubMed:9603882).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z37966 Genomic DNA Translation: CAA86021.1 Frameshift.
Y11071 Genomic DNA Translation: CAA71954.1
U00096 Genomic DNA Translation: AAC75589.1
AP009048 Genomic DNA Translation: BAA16431.1
PIRiG65030
S49295
RefSeqiNP_417031.1, NC_000913.3
WP_000244193.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75589; AAC75589; b2536
BAA16431; BAA16431; BAA16431
GeneIDi947007
KEGGiecj:JW2520
eco:b2536
PATRICifig|1411691.4.peg.4198

Similar proteinsi

Entry informationi

Entry nameiHCAT_ECOLI
AccessioniPrimary (citable) accession number: Q47142
Secondary accession number(s): O05660, P77638
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health