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Protein

Transcriptional activator FeaR

Gene

feaR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi216 – 23520H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6706-MONOMER.
ECOL316407:JW1379-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator FeaR
Gene namesi
Name:feaR
Synonyms:maoB, maoR, ydbM
Ordered Locus Names:b1384, JW1379
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13422. feaR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Transcriptional activator FeaRPRO_0000194513Add
BLAST

Proteomic databases

PaxDbiQ47129.
PRIDEiQ47129.

Interactioni

Protein-protein interaction databases

BioGridi4262991. 7 interactions.
IntActiQ47129. 3 interactions.
STRINGi511145.b1384.

Structurei

3D structure databases

ProteinModelPortaliQ47129.
SMRiQ47129. Positions 219-298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HTH araC/xylS-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108WFR. Bacteria.
COG2207. LUCA.
HOGENOMiHOG000294467.
InParanoidiQ47129.
KOiK14063.
OMAiYTVFQLE.
OrthoDBiEOG6FJNCD.
PhylomeDBiQ47129.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF14525. AraC_binding_2. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF51215. SSF51215. 1 hit.
PROSITEiPS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47129-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPAVDNEFQ QWLSQINQVC GNFTGRLLTE RYTGVLDTHF AKGLKLSTVT
60 70 80 90 100
TSGVNLSRTW QEVKGSDDAW FYTVFQLSGQ AIMEQDERQV QIGAGDITLL
110 120 130 140 150
DASRPCSLYW QESSKQISLL LPRTLLEQYF PHQKPICAER LDADLPMVQL
160 170 180 190 200
SHRLLQESMN NPALSETESE AALQAMVCLL RPVLHQRESV QPRRERQFQK
210 220 230 240 250
VVTLIDDNIR EEILRPEWIA GETGMSVRSL YRMFADKGLV VAQYIRNRRL
260 270 280 290 300
DFCADAIRHA ADDEKLAGIG FHWGFSDQSH FSTVFKQRFG MTPGEYRRKF

R
Length:301
Mass (Da):34,620
Last modified:November 1, 1997 - v1
Checksum:iBCB0B2CC67CEF652
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D67041 Genomic DNA. Translation: BAA11058.1.
X99402 Genomic DNA. Translation: CAA67779.1.
U00096 Genomic DNA. Translation: AAC74466.1.
AP009048 Genomic DNA. Translation: BAE76422.1.
X97453 Genomic DNA. Translation: CAA66105.1.
PIRiC64889.
RefSeqiNP_415902.1. NC_000913.3.
WP_001067514.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74466; AAC74466; b1384.
BAE76422; BAE76422; BAE76422.
GeneIDi945941.
KEGGiecj:JW1379.
eco:b1384.
PATRICi32118054. VBIEscCol129921_1447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D67041 Genomic DNA. Translation: BAA11058.1.
X99402 Genomic DNA. Translation: CAA67779.1.
U00096 Genomic DNA. Translation: AAC74466.1.
AP009048 Genomic DNA. Translation: BAE76422.1.
X97453 Genomic DNA. Translation: CAA66105.1.
PIRiC64889.
RefSeqiNP_415902.1. NC_000913.3.
WP_001067514.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliQ47129.
SMRiQ47129. Positions 219-298.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262991. 7 interactions.
IntActiQ47129. 3 interactions.
STRINGi511145.b1384.

Proteomic databases

PaxDbiQ47129.
PRIDEiQ47129.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74466; AAC74466; b1384.
BAE76422; BAE76422; BAE76422.
GeneIDi945941.
KEGGiecj:JW1379.
eco:b1384.
PATRICi32118054. VBIEscCol129921_1447.

Organism-specific databases

EchoBASEiEB3198.
EcoGeneiEG13422. feaR.

Phylogenomic databases

eggNOGiENOG4108WFR. Bacteria.
COG2207. LUCA.
HOGENOMiHOG000294467.
InParanoidiQ47129.
KOiK14063.
OMAiYTVFQLE.
OrthoDBiEOG6FJNCD.
PhylomeDBiQ47129.

Enzyme and pathway databases

BioCyciEcoCyc:G6706-MONOMER.
ECOL316407:JW1379-MONOMER.

Miscellaneous databases

PROiQ47129.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF14525. AraC_binding_2. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF51215. SSF51215. 1 hit.
PROSITEiPS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "maoB, a gene that encodes a positive regulator of the monoamine oxidase gene (maoA) in Escherichia coli."
    Yamashita M., Azakami H., Yokoro N., Roh J.-H., Suzuki H., Kumagai H., Murooka Y.
    J. Bacteriol. 178:2941-2947(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-6.
  2. "2-phenylethylamine catabolism by Escherichia coli K-12: gene organization and expression."
    Hanlon S.P., Hill T.K., Flavell M.A., Stringfellow J.M., Cooper R.A.
    Microbiology 143:513-518(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Molecular characterization of PadA, a phenylacetaldehyde dehydrogenase from Escherichia coli."
    Ferrandez A., Prieto M.A., Garcia J.L., Diaz E.
    FEBS Lett. 406:23-27(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-104.
    Strain: W / ATCC 11105 / DSM 1900.

Entry informationi

Entry nameiFEAR_ECOLI
AccessioniPrimary (citable) accession number: Q47129
Secondary accession number(s): Q2MBD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 20, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.