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Protein

Colicin-10

Gene

cta

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This colicin is a channel-forming colicin. This class of transmembrane toxins depolarize the cytoplasmic membrane, leading to dissipation of cellular energy.
Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriocin

Protein family/group databases

TCDBi1.C.1.2.3. the channel-forming colicin (colicin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Colicin-10
Gene namesi
Name:cta
Encoded oniPlasmid pCol100 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002186731 – 490Colicin-10Add BLAST490

Proteomic databases

PRIDEiQ47125.

Structurei

3D structure databases

ProteinModelPortaliQ47125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the channel forming colicin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.490.30. 1 hit.
InterProiIPR000293. Channel_colicin_C.
[Graphical view]
PfamiPF01024. Colicin. 1 hit.
[Graphical view]
PRINTSiPR00280. CHANLCOLICIN.
ProDomiPD002657. Channel_colicin_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00276. CHANNEL_COLICIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKVTDNSPD VESTESTEGS FPTVGVDTGD TITATLATGT ENVGGGGGAF
60 70 80 90 100
GGASESSAAI HATAKWSTAQ LKKHQAEQAA RAAAAEAALA KAKSQRDALT
110 120 130 140 150
QRLKDIVNDA LRANAARSPS VTDLAHANNM AMQAEAERLR LAKAEQKARE
160 170 180 190 200
EAEAAEKALR EAERQRDEIA RQQAETAHLL AMAEAAEAEK NRQDSLDEEH
210 220 230 240 250
RAVEVAEKKL AEAKAELAKA ESDVQSKQAI VSRVAGELEN AQKSVDVKVT
260 270 280 290 300
GFPGWRDVQK KLERQLQDKK NEYSSVTNAL NSAVSIRDAK KTEVQNAEIK
310 320 330 340 350
LKEAKDALEK SQVKDSVDTM VGFYQYITEQ YGEKYSRIAQ DLAEKAKGSK
360 370 380 390 400
FNSVDEALAA FEKYKNVLDK KFSKVDRDDI FNALESITYD EWAKHLEKIS
410 420 430 440 450
RALKVTGYLS FGYDVWDGTL KGLKTGDWKP LFVTLEKSAV DFGVAKIVAL
460 470 480 490
MFSFIVGAPL GFWGIAIITG IVSSYIGDDE LNKLNELLGI
Length:490
Mass (Da):53,343
Last modified:November 1, 1996 - v1
Checksum:i700E864DA3F97F5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82682 Genomic DNA. Translation: CAA57998.1.
PIRiI41024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82682 Genomic DNA. Translation: CAA57998.1.
PIRiI41024.

3D structure databases

ProteinModelPortaliQ47125.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.C.1.2.3. the channel-forming colicin (colicin) family.

Proteomic databases

PRIDEiQ47125.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.490.30. 1 hit.
InterProiIPR000293. Channel_colicin_C.
[Graphical view]
PfamiPF01024. Colicin. 1 hit.
[Graphical view]
PRINTSiPR00280. CHANLCOLICIN.
ProDomiPD002657. Channel_colicin_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00276. CHANNEL_COLICIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCE10_ECOLX
AccessioniPrimary (citable) accession number: Q47125
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.