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Protein

HTH-type transcriptional regulator cbl

Gene

cbl

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be an accessory regulatory protein within the cys regulon.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi19 – 3820H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • positive regulation of sulfur utilization Source: EcoliWiki
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7071-MONOMER.
ECOL316407:JW1966-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator cbl
Gene namesi
Name:cbl
Ordered Locus Names:b1987, JW1966
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14264. cbl.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316HTH-type transcriptional regulator cblPRO_0000105602Add
BLAST

Proteomic databases

PaxDbiQ47083.
PRIDEiQ47083.

Interactioni

Protein-protein interaction databases

BioGridi4262113. 6 interactions.
DIPiDIP-9248N.
IntActiQ47083. 2 interactions.
STRINGi511145.b1987.

Structurei

Secondary structure

1
316
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni88 – 903Combined sources
Beta strandi93 – 997Combined sources
Helixi101 – 1066Combined sources
Helixi108 – 11811Combined sources
Beta strandi122 – 1287Combined sources
Helixi131 – 1399Combined sources
Beta strandi144 – 1529Combined sources
Beta strandi158 – 1669Combined sources
Beta strandi168 – 1736Combined sources
Helixi177 – 1793Combined sources
Beta strandi181 – 1833Combined sources
Helixi186 – 1894Combined sources
Beta strandi194 – 1974Combined sources
Helixi204 – 21310Combined sources
Beta strandi220 – 2267Combined sources
Helixi227 – 23610Combined sources
Beta strandi240 – 2445Combined sources
Helixi245 – 2484Combined sources
Beta strandi256 – 2594Combined sources
Turni262 – 2643Combined sources
Beta strandi268 – 2758Combined sources
Helixi282 – 29110Combined sources
Beta strandi293 – 2953Combined sources
Helixi297 – 3059Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FYIX-ray2.80A/B/C/D88-307[»]
ProteinModelPortaliQ47083.
SMRiQ47083. Positions 1-307.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ47083.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5959HTH lysR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH lysR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107R11. Bacteria.
ENOG410XP61. LUCA.
HOGENOMiHOG000260068.
InParanoidiQ47083.
KOiK13635.
OMAiKVNISLH.
PhylomeDBiQ47083.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47083-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFQQLKIIR EAARQDYNLT EVANMLFTSQ SGVSRHIREL EDELGIEIFV
60 70 80 90 100
RRGKRLLGMT EPGKALLVIA ERILNEASNV RRLADLFTND TSGVLTIATT
110 120 130 140 150
HTQARYSLPE VIKAFRELFP EVRLELIQGT PQEIATLLQN GEADIGIASE
160 170 180 190 200
RLSNDPQLVA FPWFRWHHSL LVPHDHPLTQ ISPLTLESIA KWPLITYRQG
210 220 230 240 250
ITGRSRIDDA FARKGLLADI VLSAQDSDVI KTYVALGLGI GLVAEQSSGE
260 270 280 290 300
QEEENLIRLD TRHLFDANTV WLGLKRGQLQ RNYVWRFLEL CNAGLSVEDI
310
KRQVMESSEE EIDYQI
Length:316
Mass (Da):35,856
Last modified:November 1, 1997 - v2
Checksum:i70CB59476501067C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti143 – 1431A → R in AAA99929 (PubMed:8529872).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31639 Genomic DNA. Translation: AAA99929.1.
U00096 Genomic DNA. Translation: AAC75049.1.
AP009048 Genomic DNA. Translation: BAA15805.1.
PIRiC64963.
RefSeqiNP_416492.1. NC_000913.3.
WP_001011008.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75049; AAC75049; b1987.
BAA15805; BAA15805; BAA15805.
GeneIDi946502.
KEGGiecj:JW1966.
eco:b1987.
PATRICi32119305. VBIEscCol129921_2063.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31639 Genomic DNA. Translation: AAA99929.1.
U00096 Genomic DNA. Translation: AAC75049.1.
AP009048 Genomic DNA. Translation: BAA15805.1.
PIRiC64963.
RefSeqiNP_416492.1. NC_000913.3.
WP_001011008.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FYIX-ray2.80A/B/C/D88-307[»]
ProteinModelPortaliQ47083.
SMRiQ47083. Positions 1-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262113. 6 interactions.
DIPiDIP-9248N.
IntActiQ47083. 2 interactions.
STRINGi511145.b1987.

Proteomic databases

PaxDbiQ47083.
PRIDEiQ47083.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75049; AAC75049; b1987.
BAA15805; BAA15805; BAA15805.
GeneIDi946502.
KEGGiecj:JW1966.
eco:b1987.
PATRICi32119305. VBIEscCol129921_2063.

Organism-specific databases

EchoBASEiEB4012.
EcoGeneiEG14264. cbl.

Phylogenomic databases

eggNOGiENOG4107R11. Bacteria.
ENOG410XP61. LUCA.
HOGENOMiHOG000260068.
InParanoidiQ47083.
KOiK13635.
OMAiKVNISLH.
PhylomeDBiQ47083.

Enzyme and pathway databases

BioCyciEcoCyc:G7071-MONOMER.
ECOL316407:JW1966-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ47083.
PROiQ47083.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBL_ECOLI
AccessioniPrimary (citable) accession number: Q47083
Secondary accession number(s): P76353
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.