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Protein

Nitrogen assimilation regulatory protein nac

Gene

nac

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi18 – 37H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processNitrate assimilation, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G7072-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Nitrogen assimilation regulatory protein nac
Alternative name(s):
Nitrogen assimilation control protein
Gene namesi
Name:nac
Ordered Locus Names:b1988, JW1967
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14265 nac

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001056861 – 305Nitrogen assimilation regulatory protein nacAdd BLAST305

Proteomic databases

PaxDbiQ47005
PRIDEiQ47005

Interactioni

Protein-protein interaction databases

BioGridi4260407, 8 interactors
IntActiQ47005, 1 interactor
STRINGi316385.ECDH10B_2132

Structurei

3D structure databases

ProteinModelPortaliQ47005
SMRiQ47005
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Phylogenomic databases

eggNOGiENOG4106P55 Bacteria
ENOG410YGJ0 LUCA
HOGENOMiHOG000233514
InParanoidiQ47005
KOiK19338
OMAiYRHAQII
PhylomeDBiQ47005

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005119 LysR_subst-bd
IPR000847 Tscrpt_reg_HTH_LysR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00126 HTH_1, 1 hit
PF03466 LysR_substrate, 1 hit
PRINTSiPR00039 HTHLYSR
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50931 HTH_LYSR, 1 hit

Sequencei

Sequence statusi: Complete.

Q47005-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFRRLKYFV KIVDIGSLTQ AAEVLHIAQP ALSQQVATLE GELNQQLLIR
60 70 80 90 100
TKRGVTPTDA GKILYTHARA ILRQCEQAQL AVHNVGQALS GQVSIGFAPG
110 120 130 140 150
TAASSITMPL LQAVRAEFPE IVIYLHENSG AVLNEKLINH QLDMAVIYEH
160 170 180 190 200
SPVAGVSSQA LLKEDLFLVG TQDCPGQSVD VNAIAQMNLF LPSDYSAIRL
210 220 230 240 250
RVDEAFSLRR LTAKVIGEIE SIATLTAAIA SGMGVAVLPE SAARSLCGAV
260 270 280 290 300
NGWMSRITTP SMSLSLSLNL PARANLSPQA QAVKELLMSV ISSPVMEKRQ

WQLVS
Length:305
Mass (Da):32,835
Last modified:November 1, 1996 - v1
Checksum:iB0B5DC408C6C6821
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56736 Genomic DNA Translation: AAD14869.1
U00096 Genomic DNA Translation: AAC75050.1
AP009048 Genomic DNA Translation: BAA15806.1
L31639 Genomic DNA Translation: AAA99928.1
PIRiD64963
RefSeqiNP_416493.1, NC_000913.3
WP_001011462.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75050; AAC75050; b1988
BAA15806; BAA15806; BAA15806
GeneIDi946501
KEGGiecj:JW1967
eco:b1988
PATRICifig|1411691.4.peg.265

Similar proteinsi

Entry informationi

Entry nameiNAC_ECOLI
AccessioniPrimary (citable) accession number: Q47005
Secondary accession number(s): Q47082
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health