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Protein

Malate synthase

Gene

Reut_A1951

Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei163 – 1631Proton acceptorUniRule annotation
Active sitei445 – 4451Proton donorUniRule annotation

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, Transferase

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Enzyme and pathway databases

BioCyciCPIN264198:GIW3-1972-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthaseUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Ordered Locus Names:Reut_A1951Imported
OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))Imported
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002697 Componenti: Chromosome 1

Interactioni

Protein-protein interaction databases

STRINGi264198.Reut_A1951.

Structurei

3D structure databases

ProteinModelPortaliQ46ZW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the malate synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000238464.
KOiK01638.
OMAiMMINALN.
OrthoDBiEOG69WFFX.

Family and domain databases

InterProiIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001363. Malate_synth. 1 hit.
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46ZW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAITLPAGMT ITGEILPAYE DILTPEALAL VDKLHRAFEP RRQELLAARV
60 70 80 90 100
ERAKRLDAGE VPDFLPETKH IREGDWKVAP IPKALECRRV EITGPVEAKM
110 120 130 140 150
VINAFNSGAD SYMTDFEDSN TPNWHNQMQG QVNLKAAVRR TLTLESKGKQ
160 170 180 190 200
YKLNDKIATL QVRPRGWHLD EKHVTIDGKR VSGGIFDFAL FLVHNAKEQI
210 220 230 240 250
ARGDGPFFYL PKMESHLEAR LWNDIFVMAQ NEIGLPQGTI KATVLIETIL
260 270 280 290 300
AAFEMDEILY ELREHSAGLN AGRWDYIFSC IKKFKNDKNF CLADRAKVTM
310 320 330 340 350
TAPFMRAYAL LLLKTCHYRG APAMGGMSAL IPIKNDPEKN AIAMQGIIND
360 370 380 390 400
KKRDATDGYD GGWVAHPGLV EPAMKEFVAV LGDKPNQFEK QRPDVNVKGS
410 420 430 440 450
DLLDFQPETP ITEGGLRMNI NVGIHYLGAW LAGNGCVPIH NLMEDAATAE
460 470 480 490 500
ISRSQVWQWI RSPKGKLEDG TKVTAELVRK LIPEELAKVK AEVGGETKTY
510 520
DRAAEIFEQM STSEDFAEFL TLPLYEEV
Length:528
Mass (Da):59,104
Last modified:September 13, 2005 - v1
Checksum:i1115470214238841
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000090 Genomic DNA. Translation: AAZ61315.1.
RefSeqiWP_011298113.1. NC_007347.1.
YP_296159.1. NC_007347.1.

Genome annotation databases

EnsemblBacteriaiAAZ61315; AAZ61315; Reut_A1951.
KEGGireu:Reut_A1951.
PATRICi20229457. VBIRalEut24049_2586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000090 Genomic DNA. Translation: AAZ61315.1.
RefSeqiWP_011298113.1. NC_007347.1.
YP_296159.1. NC_007347.1.

3D structure databases

ProteinModelPortaliQ46ZW8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264198.Reut_A1951.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ61315; AAZ61315; Reut_A1951.
KEGGireu:Reut_A1951.
PATRICi20229457. VBIRalEut24049_2586.

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000238464.
KOiK01638.
OMAiMMINALN.
OrthoDBiEOG69WFFX.

Enzyme and pathway databases

UniPathwayiUPA00703; UER00720.
BioCyciCPIN264198:GIW3-1972-MONOMER.

Family and domain databases

InterProiIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001363. Malate_synth. 1 hit.
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome 1 of Ralstonia eutropha JMP134."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JMP134 / LMG 1197Imported.

Entry informationi

Entry nameiQ46ZW8_CUPPJ
AccessioniPrimary (citable) accession number: Q46ZW8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: April 1, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.