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Q46ZW8

- Q46ZW8_CUPPJ

UniProt

Q46ZW8 - Q46ZW8_CUPPJ

Protein

Malate synthase

Gene

Reut_A1951

Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei163 – 1631Proton acceptorUniRule annotation
    Active sitei445 – 4451Proton donorUniRule annotation

    GO - Molecular functioni

    1. malate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-UniPathway
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    AcyltransferaseImported, Transferase

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Enzyme and pathway databases

    BioCyciCPIN264198:GIW3-1972-MONOMER.
    UniPathwayiUPA00703; UER00720.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate synthaseUniRule annotation (EC:2.3.3.9UniRule annotation)
    Gene namesi
    Ordered Locus Names:Reut_A1951Imported
    OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))Imported
    Taxonomic identifieri264198 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000002697: Chromosome 1

    Interactioni

    Protein-protein interaction databases

    STRINGi264198.Reut_A1951.

    Structurei

    3D structure databases

    ProteinModelPortaliQ46ZW8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the malate synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2225.
    HOGENOMiHOG000238464.
    KOiK01638.
    OMAiSIWQWIR.
    OrthoDBiEOG69WFFX.

    Family and domain databases

    InterProiIPR011076. Malate_synth-like.
    IPR006252. Malate_synthA.
    IPR001465. Malate_synthase.
    IPR019830. Malate_synthase_CS.
    [Graphical view]
    PfamiPF01274. Malate_synthase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001363. Malate_synth. 1 hit.
    SUPFAMiSSF51645. SSF51645. 1 hit.
    TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
    PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q46ZW8-1 [UniParc]FASTAAdd to Basket

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    MAITLPAGMT ITGEILPAYE DILTPEALAL VDKLHRAFEP RRQELLAARV    50
    ERAKRLDAGE VPDFLPETKH IREGDWKVAP IPKALECRRV EITGPVEAKM 100
    VINAFNSGAD SYMTDFEDSN TPNWHNQMQG QVNLKAAVRR TLTLESKGKQ 150
    YKLNDKIATL QVRPRGWHLD EKHVTIDGKR VSGGIFDFAL FLVHNAKEQI 200
    ARGDGPFFYL PKMESHLEAR LWNDIFVMAQ NEIGLPQGTI KATVLIETIL 250
    AAFEMDEILY ELREHSAGLN AGRWDYIFSC IKKFKNDKNF CLADRAKVTM 300
    TAPFMRAYAL LLLKTCHYRG APAMGGMSAL IPIKNDPEKN AIAMQGIIND 350
    KKRDATDGYD GGWVAHPGLV EPAMKEFVAV LGDKPNQFEK QRPDVNVKGS 400
    DLLDFQPETP ITEGGLRMNI NVGIHYLGAW LAGNGCVPIH NLMEDAATAE 450
    ISRSQVWQWI RSPKGKLEDG TKVTAELVRK LIPEELAKVK AEVGGETKTY 500
    DRAAEIFEQM STSEDFAEFL TLPLYEEV 528
    Length:528
    Mass (Da):59,104
    Last modified:September 13, 2005 - v1
    Checksum:i1115470214238841
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000090 Genomic DNA. Translation: AAZ61315.1.
    RefSeqiYP_296159.1. NC_007347.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ61315; AAZ61315; Reut_A1951.
    GeneIDi3611128.
    KEGGireu:Reut_A1951.
    PATRICi20229457. VBIRalEut24049_2586.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000090 Genomic DNA. Translation: AAZ61315.1 .
    RefSeqi YP_296159.1. NC_007347.1.

    3D structure databases

    ProteinModelPortali Q46ZW8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264198.Reut_A1951.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ61315 ; AAZ61315 ; Reut_A1951 .
    GeneIDi 3611128.
    KEGGi reu:Reut_A1951.
    PATRICi 20229457. VBIRalEut24049_2586.

    Phylogenomic databases

    eggNOGi COG2225.
    HOGENOMi HOG000238464.
    KOi K01638.
    OMAi SIWQWIR.
    OrthoDBi EOG69WFFX.

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00720 .
    BioCyci CPIN264198:GIW3-1972-MONOMER.

    Family and domain databases

    InterProi IPR011076. Malate_synth-like.
    IPR006252. Malate_synthA.
    IPR001465. Malate_synthase.
    IPR019830. Malate_synthase_CS.
    [Graphical view ]
    Pfami PF01274. Malate_synthase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001363. Malate_synth. 1 hit.
    SUPFAMi SSF51645. SSF51645. 1 hit.
    TIGRFAMsi TIGR01344. malate_syn_A. 1 hit.
    PROSITEi PS00510. MALATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Ralstonia eutropha JMP134."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JMP134 / LMG 1197Imported.

    Entry informationi

    Entry nameiQ46ZW8_CUPPJ
    AccessioniPrimary (citable) accession number: Q46ZW8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 13, 2005
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3