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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei107 – 1071Proton acceptorUniRule annotation
Binding sitei125 – 1251SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciCPIN264198:GIW3-2090-MONOMER.
UniPathwayiUPA00115; UER00412.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:Reut_A2068
OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000002697 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Ribose-5-phosphate isomerase APRO_1000016972Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi264198.Reut_A2068.

Structurei

3D structure databases

ProteinModelPortaliQ46ZK1.
SMRiQ46ZK1. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni32 – 354Substrate bindingUniRule annotation
Regioni85 – 884Substrate bindingUniRule annotation
Regioni98 – 1014Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
HOGENOMiHOG000276368.
KOiK01807.
OMAiGACHVQE.
OrthoDBiPOG091H059I.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46ZK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQDELKALV AQAAADYVKQ EVPEGAVLGV GTGSTANLFI DAVAAFKDRF
60 70 80 90 100
AGAVSSSEAS TRRLQQHGFK VLDLNEVDDI PVYVDGADEI DASGAMIKGG
110 120 130 140 150
GGALTREKIV ASVAGRFVCI ADGSKLVETM GAFPLPVEVI PMARAAVARQ
160 170 180 190 200
VAALGGQPRL RMNKDGGIYK TDNGNVILDV SGLKITDPRG LEQSINQIPG
210 220
VVTVGLFALR GANVLLLGTG EGVQRTDY
Length:228
Mass (Da):23,712
Last modified:September 13, 2005 - v1
Checksum:i404405451BFEE8EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000090 Genomic DNA. Translation: AAZ61432.1.
RefSeqiWP_011298230.1. NC_007347.1.

Genome annotation databases

EnsemblBacteriaiAAZ61432; AAZ61432; Reut_A2068.
KEGGireu:Reut_A2068.
PATRICi20229709. VBIRalEut24049_2711.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000090 Genomic DNA. Translation: AAZ61432.1.
RefSeqiWP_011298230.1. NC_007347.1.

3D structure databases

ProteinModelPortaliQ46ZK1.
SMRiQ46ZK1. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264198.Reut_A2068.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ61432; AAZ61432; Reut_A2068.
KEGGireu:Reut_A2068.
PATRICi20229709. VBIRalEut24049_2711.

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
HOGENOMiHOG000276368.
KOiK01807.
OMAiGACHVQE.
OrthoDBiPOG091H059I.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.
BioCyciCPIN264198:GIW3-2090-MONOMER.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPIA_CUPPJ
AccessioniPrimary (citable) accession number: Q46ZK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.