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Protein

Guanylate kinase

Gene

gmk

Organism
Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 29ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Ordered Locus Names:Reut_A2473
OrganismiCupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000002697 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002663771 – 216Guanylate kinaseAdd BLAST216

Interactioni

Protein-protein interaction databases

STRINGi264198.Reut_A2473

Structurei

3D structure databases

ProteinModelPortaliQ46YE8
SMRiQ46YE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 193Guanylate kinase-likeUniRule annotationAdd BLAST179

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UHA Bacteria
COG0194 LUCA
HOGENOMiHOG000037638
KOiK00942
OMAiAGNYYGT
OrthoDBiPOG091H01Q4

Family and domain databases

HAMAPiMF_00328 Guanylate_kinase, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR017665 Guanylate_kinase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03263 guanyl_kin, 1 hit
PROSITEiView protein in PROSITE
PS50052 GUANYLATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q46YE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTPHTAID TVYPGNLFMV VAPSGAGKST LVNALLAQDA AIRLSISHTT
60 70 80 90 100
RAPRPGEQDG REYHFCTVDS FRAARDRGEF LEWAEVHGNY YATSRVWIEE
110 120 130 140 150
QMAQGNDVLL EIDWQGAQQV HQRFSNAVEI FILPPSLTAL EDRLKKRGQD
160 170 180 190 200
EPNVIVRRLL AAGSEMSHAS ESDYVIINEV FDNALEELRN VVRATRLRFS
210
SQKARHTELF IELGIH
Length:216
Mass (Da):24,317
Last modified:September 13, 2005 - v1
Checksum:i82B9763640A6A88F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000090 Genomic DNA Translation: AAZ61835.1
RefSeqiWP_011298623.1, NC_007347.1

Genome annotation databases

EnsemblBacteriaiAAZ61835; AAZ61835; Reut_A2473
KEGGireu:Reut_A2473

Similar proteinsi

Entry informationi

Entry nameiKGUA_CUPNJ
AccessioniPrimary (citable) accession number: Q46YE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 13, 2005
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health