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Q46YE8

- KGUA_CUPPJ

UniProt

Q46YE8 - KGUA_CUPPJ

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Protein

Guanylate kinase

Gene
gmk, Reut_A2473
Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP By similarity.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi22 – 298ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. guanylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPIN264198:GIW3-2516-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:Reut_A2473
OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002697: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Guanylate kinaseUniRule annotationPRO_0000266377Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264198.Reut_A2473.

Structurei

3D structure databases

ProteinModelPortaliQ46YE8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 193179Guanylate kinase-likeAdd
BLAST

Sequence similaritiesi

Belongs to the guanylate kinase family.

Phylogenomic databases

eggNOGiCOG0194.
HOGENOMiHOG000037638.
KOiK00942.
OMAiQMAQGND.
OrthoDBiEOG6CP410.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
HAMAPiMF_00328. Guanylate_kinase.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46YE8-1 [UniParc]FASTAAdd to Basket

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MSDTPHTAID TVYPGNLFMV VAPSGAGKST LVNALLAQDA AIRLSISHTT    50
RAPRPGEQDG REYHFCTVDS FRAARDRGEF LEWAEVHGNY YATSRVWIEE 100
QMAQGNDVLL EIDWQGAQQV HQRFSNAVEI FILPPSLTAL EDRLKKRGQD 150
EPNVIVRRLL AAGSEMSHAS ESDYVIINEV FDNALEELRN VVRATRLRFS 200
SQKARHTELF IELGIH 216
Length:216
Mass (Da):24,317
Last modified:September 13, 2005 - v1
Checksum:i82B9763640A6A88F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000090 Genomic DNA. Translation: AAZ61835.1.
RefSeqiWP_011298623.1. NC_007347.1.
YP_296679.1. NC_007347.1.

Genome annotation databases

EnsemblBacteriaiAAZ61835; AAZ61835; Reut_A2473.
GeneIDi3612196.
KEGGireu:Reut_A2473.
PATRICi20230604. VBIRalEut24049_3138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000090 Genomic DNA. Translation: AAZ61835.1 .
RefSeqi WP_011298623.1. NC_007347.1.
YP_296679.1. NC_007347.1.

3D structure databases

ProteinModelPortali Q46YE8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264198.Reut_A2473.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ61835 ; AAZ61835 ; Reut_A2473 .
GeneIDi 3612196.
KEGGi reu:Reut_A2473.
PATRICi 20230604. VBIRalEut24049_3138.

Phylogenomic databases

eggNOGi COG0194.
HOGENOMi HOG000037638.
KOi K00942.
OMAi QMAQGND.
OrthoDBi EOG6CP410.

Enzyme and pathway databases

BioCyci CPIN264198:GIW3-2516-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
HAMAPi MF_00328. Guanylate_kinase.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
PROSITEi PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Ralstonia eutropha JMP134."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JMP134 / LMG 1197.

Entry informationi

Entry nameiKGUA_CUPPJ
AccessioniPrimary (citable) accession number: Q46YE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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