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Protein

Alkyl hydroperoxide reductase AhpD

Gene

Reut_A2532

Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.SAAS annotation

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

AntioxidantSAAS annotation, Oxidoreductase, PeroxidaseSAAS annotationImported

Enzyme and pathway databases

BioCyciCPIN264198:GIW3-2576-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alkyl hydroperoxide reductase AhpDSAAS annotation (EC:1.11.1.15SAAS annotation)
Gene namesi
Ordered Locus Names:Reut_A2532Imported
OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))Imported
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000002697 Componenti: Chromosome 1

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi264198.Reut_A2532.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PRRX-ray2.15A/B/C/D/E/F/G/H/I/J/K/L1-196[»]
ProteinModelPortaliQ46Y90.
SMRiQ46Y90. Positions 3-193.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ46Y90.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 13184CMDInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the AhpD family.SAAS annotation

Keywords - Domaini

Redox-active centerSAAS annotation

Phylogenomic databases

eggNOGiENOG4107Q8N. Bacteria.
COG2128. LUCA.
HOGENOMiHOG000219400.
OMAiCLYCVVA.
OrthoDBiEOG661H7B.

Family and domain databases

Gene3Di1.20.1290.10. 1 hit.
InterProiIPR029032. AhpD-like.
IPR004675. AhpD_core.
IPR003779. CMD-like.
IPR010195. Uncharacterised_peroxidase-rel.
[Graphical view]
PfamiPF02627. CMD. 1 hit.
[Graphical view]
SUPFAMiSSF69118. SSF69118. 1 hit.
TIGRFAMsiTIGR00778. ahpD_dom. 1 hit.
TIGR01926. peroxid_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46Y90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRPAHPISR YPVPELAALP DDIRQRILEV QDKAGFVPNV FLTLAHRPDE
60 70 80 90 100
FRAFFAYHDA LMLKDGGLTK GEREMIVVAT SAANQCLYCV VAHGAILRIY
110 120 130 140 150
EKKPLVADQV AVNYLKADIP PRQRAMLDFA LKVCKASHEV NEADFEALRE
160 170 180 190
HGFTDEDAWD IAAITAFFGL SNRMANTIGM RPNDEFFLMG RVPKSK
Length:196
Mass (Da):22,018
Last modified:September 13, 2005 - v1
Checksum:i9CC8AB9F5BE48279
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000090 Genomic DNA. Translation: AAZ61893.1.
RefSeqiWP_011298681.1. NC_007347.1.

Genome annotation databases

EnsemblBacteriaiAAZ61893; AAZ61893; Reut_A2532.
KEGGireu:Reut_A2532.
PATRICi20230724. VBIRalEut24049_3197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000090 Genomic DNA. Translation: AAZ61893.1.
RefSeqiWP_011298681.1. NC_007347.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PRRX-ray2.15A/B/C/D/E/F/G/H/I/J/K/L1-196[»]
ProteinModelPortaliQ46Y90.
SMRiQ46Y90. Positions 3-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264198.Reut_A2532.

Protocols and materials databases

DNASUi3609304.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ61893; AAZ61893; Reut_A2532.
KEGGireu:Reut_A2532.
PATRICi20230724. VBIRalEut24049_3197.

Phylogenomic databases

eggNOGiENOG4107Q8N. Bacteria.
COG2128. LUCA.
HOGENOMiHOG000219400.
OMAiCLYCVVA.
OrthoDBiEOG661H7B.

Enzyme and pathway databases

BioCyciCPIN264198:GIW3-2576-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ46Y90.

Family and domain databases

Gene3Di1.20.1290.10. 1 hit.
InterProiIPR029032. AhpD-like.
IPR004675. AhpD_core.
IPR003779. CMD-like.
IPR010195. Uncharacterised_peroxidase-rel.
[Graphical view]
PfamiPF02627. CMD. 1 hit.
[Graphical view]
SUPFAMiSSF69118. SSF69118. 1 hit.
TIGRFAMsiTIGR00778. ahpD_dom. 1 hit.
TIGR01926. peroxid_rel. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of chromosome 1 of Ralstonia eutropha JMP134."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JMP134 / LMG 1197Imported.
  2. "Crystal structure of alkylhydroperoxidase AhpD core: uncharacterized peroxidase-related protein (YP_296737.1) from Ralstonia eutropha JMP134 at 2.15 A resolution."
    Joint Center for Structural Genomics (JCSG)
    Submitted (MAY-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS).

Entry informationi

Entry nameiQ46Y90_CUPPJ
AccessioniPrimary (citable) accession number: Q46Y90
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: May 11, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.