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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi381 – 388ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:Reut_A2533
OrganismiCupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000002697 Componenti: Chromosome 1

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 51HelicalUniRule annotationAdd BLAST21
Transmembranei74 – 94HelicalUniRule annotationAdd BLAST21
Transmembranei132 – 152HelicalUniRule annotationAdd BLAST21
Transmembranei159 – 179HelicalUniRule annotationAdd BLAST21
Transmembranei259 – 279HelicalUniRule annotationAdd BLAST21
Transmembranei286 – 306HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716461 – 590Lipid A export ATP-binding/permease protein MsbAAdd BLAST590

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi264198.Reut_A2533.

Structurei

3D structure databases

ProteinModelPortaliQ46Y89.
SMRiQ46Y89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 315ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini347 – 585ABC transporterUniRule annotationAdd BLAST239

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiSPLMEFL.
OrthoDBiPOG091H00DB.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46Y89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPAKSEQS AGHDVKVGKR LMGYLRPELR IFIAAILAMA VVAASEGVIP
60 70 80 90 100
KVVNDLLDKG FGGEYAGKLW HVPAILTGVA LIRGVAQFAS GYLLSLISNR
110 120 130 140 150
VLLKMRMQMF DRMLHAPAHF YHRNTAASLI NAVIFEVNQV LSILTSVFIT
160 170 180 190 200
LVRDSLTVVA LLIYLFYTNW RLTLIVSVIL PVIGYLMSKI NRRLRRLNRD
210 220 230 240 250
HQTLTNSAAY VVEEAAGGYK VVKLHGGEAY EMNRFRNMAD RLKNYSMRMA
260 270 280 290 300
VAGGLNQPVT AFLAALALSV IITIAMIQAQ GNQTTIGGFT GFVMAMLLLI
310 320 330 340 350
SPLKHLTDIN QPLTRGLTAA ELIFRLIDEP VEPQDGGVRL ERAKGDLVFE
360 370 380 390 400
RVGFRYGEGT RPALEGIDIR VPAGEVVALV GPSGSGKTTL VNLVPRFFDP
410 420 430 440 450
TDGRILLDGH AIGDIALREL RNQIAFVSQD VVLFNDTVAA NVAYGARSEE
460 470 480 490 500
EIDMARVERA LQAAYLTEVV KNLPEGVNTN IGDNGMKLSG GQRQRLAIAR
510 520 530 540 550
AIYKDAPILI LDEATSALDS ESERQVQAAL EALMVGRTTL VIAHRLSTIE
560 570 580 590
NADRIVVLDH GRVAEHGTHE ELLAANGLYA GLHRIQFATH
Length:590
Mass (Da):64,468
Last modified:September 13, 2005 - v1
Checksum:i06B9E0A8A1C7DF53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000090 Genomic DNA. Translation: AAZ61894.1.
RefSeqiWP_011298682.1. NC_007347.1.

Genome annotation databases

EnsemblBacteriaiAAZ61894; AAZ61894; Reut_A2533.
KEGGireu:Reut_A2533.

Similar proteinsi

Entry informationi

Entry nameiMSBA_CUPNJ
AccessioniPrimary (citable) accession number: Q46Y89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: September 13, 2005
Last modified: June 7, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families