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Q46Y84

- TRMD_CUPPJ

UniProt

Q46Y84 - TRMD_CUPPJ

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Protein
tRNA (guanine-N(1)-)-methyltransferase
Gene
trmD, Reut_A2538
Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Specifically methylates guanosine-37 in various tRNAs By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei117 – 1171S-adenosyl-L-methionine; via amide nitrogen By similarity

GO - Molecular functioni

  1. tRNA (guanine(37)-N(1))-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCPIN264198:GIW3-2582-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(1)-)-methyltransferase (EC:2.1.1.228)
    Alternative name(s):
    M1G-methyltransferase
    tRNA [GM37] methyltransferase
    Gene namesi
    Name:trmD
    Ordered Locus Names:Reut_A2538
    OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
    Taxonomic identifieri264198 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000002697: Chromosome 1

    Subcellular locationi

    Cytoplasm Reviewed prediction UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260tRNA (guanine-N(1)-)-methyltransferaseUniRule annotation
    PRO_0000257453Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer By similarity.UniRule annotation

    Protein-protein interaction databases

    STRINGi264198.Reut_A2538.

    Structurei

    3D structure databases

    ProteinModelPortaliQ46Y84.
    SMRiQ46Y84. Positions 1-250.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni137 – 1426S-adenosyl-L-methionine binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0336.
    HOGENOMiHOG000016242.
    KOiK00554.
    OMAiFVAGRYE.
    OrthoDBiEOG6J48RZ.

    Family and domain databases

    Gene3Di1.10.1270.20. 1 hit.
    3.40.1280.10. 1 hit.
    HAMAPiMF_00605. TrmD.
    InterProiIPR029028. Alpha/beta_knot_MTases.
    IPR002649. tRNA_m1G_MeTrfase_bac.
    IPR023148. tRNA_m1G_MeTrfase_C.
    IPR029026. tRNA_m1G_MTases_N.
    IPR016009. tRNA_MeTrfase_TRMD/TRM10.
    [Graphical view]
    PfamiPF01746. tRNA_m1G_MT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000386. tRNA_mtase. 1 hit.
    SUPFAMiSSF75217. SSF75217. 1 hit.
    TIGRFAMsiTIGR00088. trmD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q46Y84-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQFDVITLFP EMFRALTDWG ITSRAAKQQR YALRTWNPRD FTTDNYRTID    50
    DRPYGGGPGM VMLPRPLDDA IDAASAAQSQ AGVDTPHVVL MSPQGATLTH 100
    EKVMSLAQRP GLVLLCGRYE AIDQRLIDRR VHEEISLGDF VLSGGELPAM 150
    ALIDAVVRHL PGVLGDAQSA VQDSFVNGLL DCPHYTRPEE YEGVRVPEIL 200
    LGGHHAEIEK WRRQQALANT ARKRPDLIEA ARKQGLLTRA DEKFLSEWLV 250
    KEGREMSPAR 260
    Length:260
    Mass (Da):29,051
    Last modified:September 13, 2005 - v1
    Checksum:i2666526C9DD7C78E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000090 Genomic DNA. Translation: AAZ61899.1.
    RefSeqiYP_296743.1. NC_007347.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ61899; AAZ61899; Reut_A2538.
    GeneIDi3609310.
    KEGGireu:Reut_A2538.
    PATRICi20230736. VBIRalEut24049_3203.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000090 Genomic DNA. Translation: AAZ61899.1 .
    RefSeqi YP_296743.1. NC_007347.1.

    3D structure databases

    ProteinModelPortali Q46Y84.
    SMRi Q46Y84. Positions 1-250.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 264198.Reut_A2538.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ61899 ; AAZ61899 ; Reut_A2538 .
    GeneIDi 3609310.
    KEGGi reu:Reut_A2538.
    PATRICi 20230736. VBIRalEut24049_3203.

    Phylogenomic databases

    eggNOGi COG0336.
    HOGENOMi HOG000016242.
    KOi K00554.
    OMAi FVAGRYE.
    OrthoDBi EOG6J48RZ.

    Enzyme and pathway databases

    BioCyci CPIN264198:GIW3-2582-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1270.20. 1 hit.
    3.40.1280.10. 1 hit.
    HAMAPi MF_00605. TrmD.
    InterProi IPR029028. Alpha/beta_knot_MTases.
    IPR002649. tRNA_m1G_MeTrfase_bac.
    IPR023148. tRNA_m1G_MeTrfase_C.
    IPR029026. tRNA_m1G_MTases_N.
    IPR016009. tRNA_MeTrfase_TRMD/TRM10.
    [Graphical view ]
    Pfami PF01746. tRNA_m1G_MT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000386. tRNA_mtase. 1 hit.
    SUPFAMi SSF75217. SSF75217. 1 hit.
    TIGRFAMsi TIGR00088. trmD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Ralstonia eutropha JMP134."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JMP134 / LMG 1197.

    Entry informationi

    Entry nameiTRMD_CUPPJ
    AccessioniPrimary (citable) accession number: Q46Y84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: September 13, 2005
    Last modified: June 11, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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