SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q46Y84

- TRMD_CUPPJ

UniProt

Q46Y84 - TRMD_CUPPJ

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

tRNA (guanine-N(1)-)-methyltransferase

Gene
trmD, Reut_A2538
Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Specifically methylates guanosine-37 in various tRNAs By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei117 – 1171S-adenosyl-L-methionine; via amide nitrogen By similarity

GO - Molecular functioni

  1. tRNA (guanine(37)-N(1))-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCPIN264198:GIW3-2582-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(1)-)-methyltransferase (EC:2.1.1.228)
Alternative name(s):
M1G-methyltransferase
tRNA [GM37] methyltransferase
Gene namesi
Name:trmD
Ordered Locus Names:Reut_A2538
OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002697: Chromosome 1

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260tRNA (guanine-N(1)-)-methyltransferaseUniRule annotationPRO_0000257453Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi264198.Reut_A2538.

Structurei

3D structure databases

ProteinModelPortaliQ46Y84.
SMRiQ46Y84. Positions 1-250.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni137 – 1426S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0336.
HOGENOMiHOG000016242.
KOiK00554.
OMAiFVAGRYE.
OrthoDBiEOG6J48RZ.

Family and domain databases

Gene3Di1.10.1270.20. 1 hit.
3.40.1280.10. 1 hit.
HAMAPiMF_00605. TrmD.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR002649. tRNA_m1G_MeTrfase_bac.
IPR023148. tRNA_m1G_MeTrfase_C.
IPR029026. tRNA_m1G_MTases_N.
IPR016009. tRNA_MeTrfase_TRMD/TRM10.
[Graphical view]
PfamiPF01746. tRNA_m1G_MT. 1 hit.
[Graphical view]
PIRSFiPIRSF000386. tRNA_mtase. 1 hit.
SUPFAMiSSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00088. trmD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46Y84-1 [UniParc]FASTAAdd to Basket

« Hide

MQFDVITLFP EMFRALTDWG ITSRAAKQQR YALRTWNPRD FTTDNYRTID    50
DRPYGGGPGM VMLPRPLDDA IDAASAAQSQ AGVDTPHVVL MSPQGATLTH 100
EKVMSLAQRP GLVLLCGRYE AIDQRLIDRR VHEEISLGDF VLSGGELPAM 150
ALIDAVVRHL PGVLGDAQSA VQDSFVNGLL DCPHYTRPEE YEGVRVPEIL 200
LGGHHAEIEK WRRQQALANT ARKRPDLIEA ARKQGLLTRA DEKFLSEWLV 250
KEGREMSPAR 260
Length:260
Mass (Da):29,051
Last modified:September 13, 2005 - v1
Checksum:i2666526C9DD7C78E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000090 Genomic DNA. Translation: AAZ61899.1.
RefSeqiYP_296743.1. NC_007347.1.

Genome annotation databases

EnsemblBacteriaiAAZ61899; AAZ61899; Reut_A2538.
GeneIDi3609310.
KEGGireu:Reut_A2538.
PATRICi20230736. VBIRalEut24049_3203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000090 Genomic DNA. Translation: AAZ61899.1 .
RefSeqi YP_296743.1. NC_007347.1.

3D structure databases

ProteinModelPortali Q46Y84.
SMRi Q46Y84. Positions 1-250.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264198.Reut_A2538.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ61899 ; AAZ61899 ; Reut_A2538 .
GeneIDi 3609310.
KEGGi reu:Reut_A2538.
PATRICi 20230736. VBIRalEut24049_3203.

Phylogenomic databases

eggNOGi COG0336.
HOGENOMi HOG000016242.
KOi K00554.
OMAi FVAGRYE.
OrthoDBi EOG6J48RZ.

Enzyme and pathway databases

BioCyci CPIN264198:GIW3-2582-MONOMER.

Family and domain databases

Gene3Di 1.10.1270.20. 1 hit.
3.40.1280.10. 1 hit.
HAMAPi MF_00605. TrmD.
InterProi IPR029028. Alpha/beta_knot_MTases.
IPR002649. tRNA_m1G_MeTrfase_bac.
IPR023148. tRNA_m1G_MeTrfase_C.
IPR029026. tRNA_m1G_MTases_N.
IPR016009. tRNA_MeTrfase_TRMD/TRM10.
[Graphical view ]
Pfami PF01746. tRNA_m1G_MT. 1 hit.
[Graphical view ]
PIRSFi PIRSF000386. tRNA_mtase. 1 hit.
SUPFAMi SSF75217. SSF75217. 1 hit.
TIGRFAMsi TIGR00088. trmD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Ralstonia eutropha JMP134."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JMP134 / LMG 1197.

Entry informationi

Entry nameiTRMD_CUPPJ
AccessioniPrimary (citable) accession number: Q46Y84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 13, 2005
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi